Small molecule mimetics of an interferon-α receptor interacting domain

Small molecules that mimic IFN-α epitopes that interact with the cell surface receptor, IFNAR, would be useful therapeutics. One such 8-amino acid region in IFN-α2, designated IRRP-1, was used to derive 11 chemical compounds that belong to 5 distinct chemotypes, containing the molecular features rep...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2014-02, Vol.22 (3), p.978-985
Hauptverfasser:	Bello, Angelica M., Wei, Lianhu, Majchrzak-Kita, Beata, Salum, Noruê, Purohit, Meena K., Fish, Eleanor N., Kotra, Lakshmi P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic Acid - chemistry Cell Line - drug effects Drug Evaluation, Preclinical - methods Epitopes - chemistry Epitopes - metabolism Humans IFN-α receptor Interferon Interferon-alpha - metabolism Models, Molecular Molecular Mimicry Peptides - chemistry Peptidomimetics Phosphorylation - drug effects Protein Conformation Protein Structure, Tertiary Receptor, Interferon alpha-beta - chemistry Receptor, Interferon alpha-beta - metabolism Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology STAT1 Transcription Factor - metabolism
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