Synthesis and structure–activity relationship of p-carborane-based non-secosteroidal vitamin D analogs

1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3: 1] is a specific modulator of nuclear vitamin D receptor (VDR), and novel vitamin D analogs are therapeutic candidates for multiple clinical applications. We recently developed non-secosteroidal VDR agonists bearing a p-carborane cage (a carbon-containing bor...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2014-02, Vol.22 (4), p.1227-1235
Hauptverfasser:	Fujii, Shinya, Kano, Atsushi, Songkram, Chalermkiat, Masuno, Hiroyuki, Taoda, Yoshiyuki, Kawachi, Emiko, Hirano, Tomoya, Tanatani, Aya, Kagechika, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Boranes - chemistry Carborane Cell Proliferation - drug effects HL-60 Cells Humans Non-secosteroid Nuclear receptor Receptors, Calcitriol - agonists Receptors, Calcitriol - metabolism Stereoisomerism Structure-Activity Relationship Vitamin D Vitamin D - analogs & derivatives Vitamin D - chemical synthesis Vitamin D - pharmacology Vitamins - chemical synthesis Vitamins - pharmacology
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