Rationally designed nanovehicles to overcome cancer chemoresistance
Drug resistance is a primary hindrance towards curative cancer chemotherapy. Nanotechnology holds great promise in establishing efficacious and innovative strategies to overcome chemoresistance, and markedly facilitate complementary treatments and cancer diagnostics. Various nanomedical devices are...
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| Veröffentlicht in: | Advanced drug delivery reviews 2013-11, Vol.65 (13-14), p.1716-1730 |
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| container_title | Advanced drug delivery reviews |
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| creator | Livney, Yoav D. Assaraf, Yehuda G. |
| description | Drug resistance is a primary hindrance towards curative cancer chemotherapy. Nanotechnology holds great promise in establishing efficacious and innovative strategies to overcome chemoresistance, and markedly facilitate complementary treatments and cancer diagnostics. Various nanomedical devices are being introduced and evaluated, demonstrating encouraging results. While stealth liposomes serve as a benchmark, astonishing progress is witnessed in polymeric nanovehicles, sometimes combined with low molecular weight surfactants, some of which inhibit drug resistance in addition to solubilizing drugs. Cutting edge multifunctional or quadrugnostic nanoparticles currently developed offer simultaneous targeted delivery of chemotherapeutics and chemosensitizers or drug-resistance gene silencing cargo, along with diagnostic imaging agents, like metallic NPs. Viral and cellular components offer exciting new routes for cancer targeting and treatment. Targeting intracellular compartments is another challenging frontier spawning pioneering approaches and results. To further enhance rational design of nanomedicine for overcoming drug resistance, we review the latest thoughts and accomplishments in recent literature.
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| doi_str_mv | 10.1016/j.addr.2013.08.006 |
| format | Article |
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[Display omitted]</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cancer</subject><subject>Diagnostic imaging</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Design</subject><subject>Drug Resistance, Neoplasm</subject><subject>Humans</subject><subject>Ligands</subject><subject>MDR</subject><subject>Multifunctional nanovehicles</subject><subject>Nanomedicine</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Overcoming drug resistance</subject><subject>Polymeric nanoparticles</subject><subject>Quadrugnostic</subject><subject>Theranostic</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoOo7-ARfSpZvW3DZNU3Ajgy8QBFFwF_K4dTK0jSYdwX9vhlGXurqcy3fO4iPkBGgBFPj5qlDWhqKkUBVUFJTyHTID0ZS5KFu2S2YJanNG25cDchjjilIoG073yUFZtTVrBMzI4lFNzo-q7z8zi9G9jmizUY3-A5fO9BizyWcpBOMHzIwaDYbMLHHwIdFx2jyOyF6n-ojH33dOnq-vnha3-f3Dzd3i8j43rBJTznlTdsrQWnfGClYhsFpXzGINne2owA6gUa3WqAG0rVDQTnFhtWlVbbWu5uRsu_sW_Psa4yQHFw32vRrRr6OEGnjDalHW_6OMJ1ECGp7Qcoua4GMM2Mm34AYVPiVQufEsV3LjWW48Sypk8pxKp9_7az2g_a38iE3AxRbAJOTDYZDROEyyrAtoJmm9-2v_C7vjkCg</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Livney, Yoav D.</creator><creator>Assaraf, Yehuda G.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201311</creationdate><title>Rationally designed nanovehicles to overcome cancer chemoresistance</title><author>Livney, Yoav D. ; Assaraf, Yehuda G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-6672fac05bfcd843e145b34de51fdf08ef117a9bbeb11bd3e80fa68dbc9a5dbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cancer</topic><topic>Diagnostic imaging</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Design</topic><topic>Drug Resistance, Neoplasm</topic><topic>Humans</topic><topic>Ligands</topic><topic>MDR</topic><topic>Multifunctional nanovehicles</topic><topic>Nanomedicine</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Overcoming drug resistance</topic><topic>Polymeric nanoparticles</topic><topic>Quadrugnostic</topic><topic>Theranostic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Livney, Yoav D.</creatorcontrib><creatorcontrib>Assaraf, Yehuda G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Livney, Yoav D.</au><au>Assaraf, Yehuda G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rationally designed nanovehicles to overcome cancer chemoresistance</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2013-11</date><risdate>2013</risdate><volume>65</volume><issue>13-14</issue><spage>1716</spage><epage>1730</epage><pages>1716-1730</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Drug resistance is a primary hindrance towards curative cancer chemotherapy. Nanotechnology holds great promise in establishing efficacious and innovative strategies to overcome chemoresistance, and markedly facilitate complementary treatments and cancer diagnostics. Various nanomedical devices are being introduced and evaluated, demonstrating encouraging results. While stealth liposomes serve as a benchmark, astonishing progress is witnessed in polymeric nanovehicles, sometimes combined with low molecular weight surfactants, some of which inhibit drug resistance in addition to solubilizing drugs. Cutting edge multifunctional or quadrugnostic nanoparticles currently developed offer simultaneous targeted delivery of chemotherapeutics and chemosensitizers or drug-resistance gene silencing cargo, along with diagnostic imaging agents, like metallic NPs. Viral and cellular components offer exciting new routes for cancer targeting and treatment. Targeting intracellular compartments is another challenging frontier spawning pioneering approaches and results. To further enhance rational design of nanomedicine for overcoming drug resistance, we review the latest thoughts and accomplishments in recent literature.
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| ispartof | Advanced drug delivery reviews, 2013-11, Vol.65 (13-14), p.1716-1730 |
| issn | 0169-409X 1872-8294 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Cancer Diagnostic imaging Drug Carriers - chemistry Drug Design Drug Resistance, Neoplasm Humans Ligands MDR Multifunctional nanovehicles Nanomedicine Nanoparticles - chemistry Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Overcoming drug resistance Polymeric nanoparticles Quadrugnostic Theranostic |
| title | Rationally designed nanovehicles to overcome cancer chemoresistance |
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