Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia
Background Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by exposure to solar radiation. Objectives This study was conducted to evaluate the clinicopathologic profile of cases of AC and to verify associations with the degree of dysplasia. Methods This retrospective stu...
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| Veröffentlicht in: | International journal of dermatology 2014-04, Vol.53 (4), p.466-472 |
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| container_title | International journal of dermatology |
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| creator | de Santana Sarmento, Dmitry José da Costa Miguel, Márcia Cristina Queiroz, Lélia Maria Guedes Godoy, Gustavo Pina da Silveira, Éricka Janine Dantas |
| description | Background
Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by exposure to solar radiation.
Objectives
This study was conducted to evaluate the clinicopathologic profile of cases of AC and to verify associations with the degree of dysplasia.
Methods
This retrospective study analyzed data for 40 patients with AC. Demographic, clinical, and histopathologic data were evaluated. Sections measuring 5 μm in thickness were cut, deparaffinized, and stained with hematoxylin and eosin for histologic examination. The degree of epithelial dysplasia was graded using the criteria defined by the World Health Organization. Two calibrated oral pathologists analyzed the slides.
Results
Analysis of the AC patients sampled showed that 75.0% were male (P = 0.002), 80.0% were aged ≥40 years (P |
| doi_str_mv | 10.1111/ijd.12332 |
| format | Article |
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Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by exposure to solar radiation.
Objectives
This study was conducted to evaluate the clinicopathologic profile of cases of AC and to verify associations with the degree of dysplasia.
Methods
This retrospective study analyzed data for 40 patients with AC. Demographic, clinical, and histopathologic data were evaluated. Sections measuring 5 μm in thickness were cut, deparaffinized, and stained with hematoxylin and eosin for histologic examination. The degree of epithelial dysplasia was graded using the criteria defined by the World Health Organization. Two calibrated oral pathologists analyzed the slides.
Results
Analysis of the AC patients sampled showed that 75.0% were male (P = 0.002), 80.0% were aged ≥40 years (P < 0.001), 74.3% were Caucasian (P = 0.004), and 68.6% had occupational exposure to sunlight (P = 0.028). The most common clinical manifestation was white lesions (55.0%), and 40.0% of patients had no dysplasia. No significant associations emerged between the histologic grading of AC and gender (P = 1.000), age (P = 1.000), ethnicity (P = 0.416), occupational exposure to sunlight (P = 1.000), and clinical presentation (P = 0.467).
Conclusions
The degree of dysplasia in AC was not statistically associated with gender, age, ethnicity, occupational exposure to sunlight, or clinical appearance. This study provides some support for the hypothesis that clinicopathologic features are not related to the degree of dysplasia in AC.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.12332</identifier><identifier>PMID: 24320079</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; African Continental Ancestry Group ; Age Factors ; Brazil ; Cheilitis - ethnology ; Cheilitis - etiology ; Cheilitis - pathology ; Epithelium - pathology ; European Continental Ancestry Group ; Female ; Humans ; Male ; Occupational Exposure ; Retrospective Studies ; Sex Factors ; Sunlight - adverse effects</subject><ispartof>International journal of dermatology, 2014-04, Vol.53 (4), p.466-472</ispartof><rights>2013 The International Society of Dermatology</rights><rights>2013 The International Society of Dermatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3962-3d4e32b170e13395b43afa32d8f258d29334dfdd494c9f6303bc0eeebe3b009f3</citedby><cites>FETCH-LOGICAL-c3962-3d4e32b170e13395b43afa32d8f258d29334dfdd494c9f6303bc0eeebe3b009f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.12332$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.12332$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24320079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Santana Sarmento, Dmitry José</creatorcontrib><creatorcontrib>da Costa Miguel, Márcia Cristina</creatorcontrib><creatorcontrib>Queiroz, Lélia Maria Guedes</creatorcontrib><creatorcontrib>Godoy, Gustavo Pina</creatorcontrib><creatorcontrib>da Silveira, Éricka Janine Dantas</creatorcontrib><title>Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by exposure to solar radiation.
Objectives
This study was conducted to evaluate the clinicopathologic profile of cases of AC and to verify associations with the degree of dysplasia.
Methods
This retrospective study analyzed data for 40 patients with AC. Demographic, clinical, and histopathologic data were evaluated. Sections measuring 5 μm in thickness were cut, deparaffinized, and stained with hematoxylin and eosin for histologic examination. The degree of epithelial dysplasia was graded using the criteria defined by the World Health Organization. Two calibrated oral pathologists analyzed the slides.
Results
Analysis of the AC patients sampled showed that 75.0% were male (P = 0.002), 80.0% were aged ≥40 years (P < 0.001), 74.3% were Caucasian (P = 0.004), and 68.6% had occupational exposure to sunlight (P = 0.028). The most common clinical manifestation was white lesions (55.0%), and 40.0% of patients had no dysplasia. No significant associations emerged between the histologic grading of AC and gender (P = 1.000), age (P = 1.000), ethnicity (P = 0.416), occupational exposure to sunlight (P = 1.000), and clinical presentation (P = 0.467).
Conclusions
The degree of dysplasia in AC was not statistically associated with gender, age, ethnicity, occupational exposure to sunlight, or clinical appearance. This study provides some support for the hypothesis that clinicopathologic features are not related to the degree of dysplasia in AC.</description><subject>Adult</subject><subject>African Continental Ancestry Group</subject><subject>Age Factors</subject><subject>Brazil</subject><subject>Cheilitis - ethnology</subject><subject>Cheilitis - etiology</subject><subject>Cheilitis - pathology</subject><subject>Epithelium - pathology</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Occupational Exposure</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Sunlight - adverse effects</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PGzEQhi1UBCFw4A9Ue2wPC7bHuxv3hiif5eOSEImL5bXHxHQTh_VGkH-PISG3SvVlZM8z71gPIYeMHrF0jv2zPWIcgG-RHoOyyEUJ_BvpUcpYLmkhd8lejM_pCpyJHbLLBXBKK9kjoxPT-Zk3mZmgb3zn46_MNB8vYa67SWjCU2rO2-B8g5me2UzHGIzXnQ-z7NV3k8ziU4uYBZfZZZw3Onq9T7adbiIerGufjM7PhqeX-c39xdXpyU1uQJY8BysQeM0qigxAFrUA7TRwO3C8GFguAYR11gopjHQlUKgNRcQaoaZUOuiTH6vc9MGXBcZOTX002DR6hmERFStYWYkC6OA_UCoFE0Va2ic_V6hpQ4wtOjVv_VS3S8Wo-hCuknD1KTyx39exi3qKdkN-GU7A8Qp4TQKX_05SV9e_vyLz1YSPHb5tJnT7V5UVVIUa312o4W05_PNwOVaP8A60Bplp</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>de Santana Sarmento, Dmitry José</creator><creator>da Costa Miguel, Márcia Cristina</creator><creator>Queiroz, Lélia Maria Guedes</creator><creator>Godoy, Gustavo Pina</creator><creator>da Silveira, Éricka Janine Dantas</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201404</creationdate><title>Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia</title><author>de Santana Sarmento, Dmitry José ; da Costa Miguel, Márcia Cristina ; Queiroz, Lélia Maria Guedes ; Godoy, Gustavo Pina ; da Silveira, Éricka Janine Dantas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3962-3d4e32b170e13395b43afa32d8f258d29334dfdd494c9f6303bc0eeebe3b009f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>African Continental Ancestry Group</topic><topic>Age Factors</topic><topic>Brazil</topic><topic>Cheilitis - ethnology</topic><topic>Cheilitis - etiology</topic><topic>Cheilitis - pathology</topic><topic>Epithelium - pathology</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Occupational Exposure</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Sunlight - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Santana Sarmento, Dmitry José</creatorcontrib><creatorcontrib>da Costa Miguel, Márcia Cristina</creatorcontrib><creatorcontrib>Queiroz, Lélia Maria Guedes</creatorcontrib><creatorcontrib>Godoy, Gustavo Pina</creatorcontrib><creatorcontrib>da Silveira, Éricka Janine Dantas</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Santana Sarmento, Dmitry José</au><au>da Costa Miguel, Márcia Cristina</au><au>Queiroz, Lélia Maria Guedes</au><au>Godoy, Gustavo Pina</au><au>da Silveira, Éricka Janine Dantas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2014-04</date><risdate>2014</risdate><volume>53</volume><issue>4</issue><spage>466</spage><epage>472</epage><pages>466-472</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by exposure to solar radiation.
Objectives
This study was conducted to evaluate the clinicopathologic profile of cases of AC and to verify associations with the degree of dysplasia.
Methods
This retrospective study analyzed data for 40 patients with AC. Demographic, clinical, and histopathologic data were evaluated. Sections measuring 5 μm in thickness were cut, deparaffinized, and stained with hematoxylin and eosin for histologic examination. The degree of epithelial dysplasia was graded using the criteria defined by the World Health Organization. Two calibrated oral pathologists analyzed the slides.
Results
Analysis of the AC patients sampled showed that 75.0% were male (P = 0.002), 80.0% were aged ≥40 years (P < 0.001), 74.3% were Caucasian (P = 0.004), and 68.6% had occupational exposure to sunlight (P = 0.028). The most common clinical manifestation was white lesions (55.0%), and 40.0% of patients had no dysplasia. No significant associations emerged between the histologic grading of AC and gender (P = 1.000), age (P = 1.000), ethnicity (P = 0.416), occupational exposure to sunlight (P = 1.000), and clinical presentation (P = 0.467).
Conclusions
The degree of dysplasia in AC was not statistically associated with gender, age, ethnicity, occupational exposure to sunlight, or clinical appearance. This study provides some support for the hypothesis that clinicopathologic features are not related to the degree of dysplasia in AC.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24320079</pmid><doi>10.1111/ijd.12332</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Journals |
| subjects | Adult African Continental Ancestry Group Age Factors Brazil Cheilitis - ethnology Cheilitis - etiology Cheilitis - pathology Epithelium - pathology European Continental Ancestry Group Female Humans Male Occupational Exposure Retrospective Studies Sex Factors Sunlight - adverse effects |
| title | Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia |
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