Insights in the chemical components of liposomes responsible for P-glycoprotein inhibition

Abstract In this work we investigated how the surface charge and the presence of polyethylene glycol (PEG) on liposome carriers affect the delivery of the encapsulated doxorubicin in P-glycoprotein (Pgp)-overexpressing cells. We found that neutral net charge was critical to favour the liposome uptak...

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Veröffentlicht in:	Nanomedicine 2014, Vol.10 (1), p.77-87
Hauptverfasser:	Kopecka, Joanna, Msc, PhD, Salzano, Giuseppina, PharmD, Campia, Ivana, Msc, Lusa, Sara, Msc, Ghigo, Dario, MD, De Rosa, Giuseppe, PhD, Riganti, Chiara, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors Chemoresistance Doxorubicin Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Delivery Systems Drug Resistance, Neoplasm - drug effects Humans Internal Medicine Liposome Liposomes - administration & dosage Liposomes - chemistry Neoplasms - drug therapy P-glycoprotein Polyethylene glycol Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Surface Properties
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