1,2,3-Triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: Potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones

1,2,3-Triazole-, arylamino- and thio-substituted naphthoquinones (24, 8, and 2 representatives, respectively) were synthesized in moderate yields and evaluated against several human cancer cell lines (blood, ovarian, breast, central nervous system, colon, and prostate cancers and melanoma), showing,...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2014-03, Vol.22 (5), p.1608-1619
Hauptverfasser:	da Cruz, Eduardo H.G., Hussene, Caio M.B., Dias, Gleiston G., Diogo, Emilay B.T., de Melo, Isadora M.M., Rodrigues, Bernardo L., da Silva, Mauro G., Valença, Wagner O., Camara, Celso A., de Oliveira, Ronaldo N., de Paiva, Yen G., Goulart, Marilia O.F., Cavalcanti, Bruno C., Pessoa, Claudia, da Silva Júnior, Eufrânio N.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3-Triazoles 1,4-Naphthoquinone Cancer Cell Proliferation Click Chemistry Humans Lapachol Models, Molecular Molecular Structure Naphthoquinones - chemistry Structure-Activity Relationship Triazoles - chemistry
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