The enzyme 3-hydroxykynurenine transaminase as potential target for 1,2,4-oxadiazoles with larvicide activity against the dengue vector Aedes aegypti

The mosquito Aedes aegypti is the vector agent responsible for the transmission of yellow fever and dengue fever viruses to over 80million people in tropical and subtropical regions of the world. Exhaustive efforts have lead to a vaccine candidate with only 30% effectiveness against the dengue virus...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-11, Vol.21 (22), p.6996-7003
Hauptverfasser:	Oliveira, Vanessa S., Pimenteira, Cecília, da Silva-Alves, Diana C.B., Leal, Laylla L.L., Neves-Filho, Ricardo A.W., Navarro, Daniela M.A.F., Santos, Geanne K.N., Dutra, Kamilla A., dos Anjos, Janaína V., Soares, Thereza A.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(2-Aminophenyl)-4-oxobutanoic acid Aedes - drug effects Aedes - enzymology Aedes - growth & development Aedes aegypti Animals Binding Sites Dengue virus Insecticide Insecticides Larva - drug effects Larva - enzymology Larvae pigmentation Malaria vector Anopheles gambiae Molecular docking calculations Molecular Docking Simulation Oxadiazoles - chemical synthesis Oxadiazoles - chemistry Oxadiazoles - pharmacology Protein Structure, Tertiary Structure-Activity Relationship Transaminases - antagonists & inhibitors Transaminases - metabolism
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