Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study
Background Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma. Objective We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing. Methods We perfo...
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| creator | Guxens, Mònica, MD, MPH, PhD Sonnenschein–van der Voort, Agnes M.M., MSc Tiemeier, Henning, MD, PhD Hofman, Albert, MD, PhD Sunyer, Jordi, MD, PhD de Jongste, Johan C., MD, PhD Jaddoe, Vincent W.V., MD, PhD Duijts, Liesbeth, MD, PhD |
| description | Background Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma. Objective We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing. Methods We performed a population-based prospective cohort study among 4848 children. We assessed maternal and paternal psychological distress at the second trimester of gestation and 3 years after delivery and maternal psychological distress at 2 and 6 months after delivery by using the Brief Symptom Inventory questionnaire. Wheezing in the children was annually examined by using questionnaires from 1 to 4 years. Physician-diagnosed ever asthma was reported at 6 years. Results Mothers with psychological distress during pregnancy had increased odds of wheezing in their children from 1 to 4 years of life (overall distress: odds ratio [OR], 1.60 [95% CI, 1.32-1.93]; depression: OR, 1.46 [95% CI, 1.20-1.77]; and anxiety: OR, 1.39 [95% CI, 1.15-1.67]). We observed similar positive associations with the number of wheezing episodes, wheezing patterns, and physician-diagnosed asthma at 6 years. Paternal distress during pregnancy and maternal and paternal distress after delivery did not affect these results and were not associated with childhood wheezing. Conclusion Maternal psychological distress during pregnancy is associated with increased odds of wheezing in their children during the first 6 years of life independent of paternal psychological distress during pregnancy and maternal and paternal psychological distress after delivery. These results suggest a possible intrauterine programming effect of maternal psychological distress leading to respiratory morbidity. |
| doi_str_mv | 10.1016/j.jaci.2013.04.044 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1516744599</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S009167491300691X</els_id><sourcerecordid>3415482231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c502t-98db2e8457d7ca2d01d8933090dd6955c9f11711639a11c93fc9bd0859041eed3</originalsourceid><addsrcrecordid>eNqFklGLEzEQxxdRvHr6BXyQBRF8aZ3ZJLuJHIIcegoHineCbyFNpm1622xNdpX105ul1YN7UBgIk_zmT2b-UxRPERYIWL_aLrbG-kUFyBbAc_B7xQxBNfNaVuJ-MQNQOK8brk6KRyltIedMqofFScWappGCz4qbzyZS6E1b7tNoN13brb3NmfOpj5RS6Ybow7rcR1oHE-xYmuDKnxuiX9O1D9NLyoVdW9qNb11We11eb6i8oEDR9L4L5Zfyqh_c-Lh4sDJtoifH87T4-v7d9fmH-eWni4_nby_nVkDVz5V0y4okF41rrKkcoJOKMVDgXK2EsGqF2CDWTBlEq9jKqqUDKRRwJHLstHh50N3H7vtAqdc7nyy1rQnUDUmjwDwULpT6P8oVNJLXvMro8zvothtiyI1kQdEgMCnrTFUHysYupUgrvY9-Z-KoEfTkmt7qyTU9uaaB5-C56NlReljuyP0t-WNTBl4cAZOyO6uYnfDplpPIhaghc2cHjvJ4f3iKOllPwZLzkWyvXef__Y83d8pt68O0Dzc0UrrtV6dKg76a9mtaL2QAtcJv7DcZPcmT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1557103886</pqid></control><display><type>article</type><title>Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Guxens, Mònica, MD, MPH, PhD ; Sonnenschein–van der Voort, Agnes M.M., MSc ; Tiemeier, Henning, MD, PhD ; Hofman, Albert, MD, PhD ; Sunyer, Jordi, MD, PhD ; de Jongste, Johan C., MD, PhD ; Jaddoe, Vincent W.V., MD, PhD ; Duijts, Liesbeth, MD, PhD</creator><creatorcontrib>Guxens, Mònica, MD, MPH, PhD ; Sonnenschein–van der Voort, Agnes M.M., MSc ; Tiemeier, Henning, MD, PhD ; Hofman, Albert, MD, PhD ; Sunyer, Jordi, MD, PhD ; de Jongste, Johan C., MD, PhD ; Jaddoe, Vincent W.V., MD, PhD ; Duijts, Liesbeth, MD, PhD</creatorcontrib><description>Background Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma. Objective We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing. Methods We performed a population-based prospective cohort study among 4848 children. We assessed maternal and paternal psychological distress at the second trimester of gestation and 3 years after delivery and maternal psychological distress at 2 and 6 months after delivery by using the Brief Symptom Inventory questionnaire. Wheezing in the children was annually examined by using questionnaires from 1 to 4 years. Physician-diagnosed ever asthma was reported at 6 years. Results Mothers with psychological distress during pregnancy had increased odds of wheezing in their children from 1 to 4 years of life (overall distress: odds ratio [OR], 1.60 [95% CI, 1.32-1.93]; depression: OR, 1.46 [95% CI, 1.20-1.77]; and anxiety: OR, 1.39 [95% CI, 1.15-1.67]). We observed similar positive associations with the number of wheezing episodes, wheezing patterns, and physician-diagnosed asthma at 6 years. Paternal distress during pregnancy and maternal and paternal distress after delivery did not affect these results and were not associated with childhood wheezing. Conclusion Maternal psychological distress during pregnancy is associated with increased odds of wheezing in their children during the first 6 years of life independent of paternal psychological distress during pregnancy and maternal and paternal psychological distress after delivery. These results suggest a possible intrauterine programming effect of maternal psychological distress leading to respiratory morbidity.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2013.04.044</identifier><identifier>PMID: 23777854</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Age ; Allergy and Immunology ; Anxiety ; Asthma ; Biological and medical sciences ; Body mass index ; Breastfeeding & lactation ; Child ; child development ; Child, Preschool ; Cohort Studies ; depression ; Ethnicity ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunopathology ; Infant ; Infant, Newborn ; Inventory ; Male ; Maternal Exposure - adverse effects ; Medical sciences ; Miscellaneous ; Mothers ; Mothers - psychology ; Paternal Exposure - adverse effects ; Pregnancy ; Pregnancy Complications - epidemiology ; Prenatal Exposure Delayed Effects - epidemiology ; preschool ; Prospective Studies ; psychological ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Questionnaires ; Respiratory Sounds ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Stress ; Stress, Psychological - epidemiology ; Tobacco smoke</subject><ispartof>Journal of allergy and clinical immunology, 2014-01, Vol.133 (1), p.59-67.e12</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2013 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-98db2e8457d7ca2d01d8933090dd6955c9f11711639a11c93fc9bd0859041eed3</citedby><cites>FETCH-LOGICAL-c502t-98db2e8457d7ca2d01d8933090dd6955c9f11711639a11c93fc9bd0859041eed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S009167491300691X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28145560$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23777854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guxens, Mònica, MD, MPH, PhD</creatorcontrib><creatorcontrib>Sonnenschein–van der Voort, Agnes M.M., MSc</creatorcontrib><creatorcontrib>Tiemeier, Henning, MD, PhD</creatorcontrib><creatorcontrib>Hofman, Albert, MD, PhD</creatorcontrib><creatorcontrib>Sunyer, Jordi, MD, PhD</creatorcontrib><creatorcontrib>de Jongste, Johan C., MD, PhD</creatorcontrib><creatorcontrib>Jaddoe, Vincent W.V., MD, PhD</creatorcontrib><creatorcontrib>Duijts, Liesbeth, MD, PhD</creatorcontrib><title>Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma. Objective We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing. Methods We performed a population-based prospective cohort study among 4848 children. We assessed maternal and paternal psychological distress at the second trimester of gestation and 3 years after delivery and maternal psychological distress at 2 and 6 months after delivery by using the Brief Symptom Inventory questionnaire. Wheezing in the children was annually examined by using questionnaires from 1 to 4 years. Physician-diagnosed ever asthma was reported at 6 years. Results Mothers with psychological distress during pregnancy had increased odds of wheezing in their children from 1 to 4 years of life (overall distress: odds ratio [OR], 1.60 [95% CI, 1.32-1.93]; depression: OR, 1.46 [95% CI, 1.20-1.77]; and anxiety: OR, 1.39 [95% CI, 1.15-1.67]). We observed similar positive associations with the number of wheezing episodes, wheezing patterns, and physician-diagnosed asthma at 6 years. Paternal distress during pregnancy and maternal and paternal distress after delivery did not affect these results and were not associated with childhood wheezing. Conclusion Maternal psychological distress during pregnancy is associated with increased odds of wheezing in their children during the first 6 years of life independent of paternal psychological distress during pregnancy and maternal and paternal psychological distress after delivery. These results suggest a possible intrauterine programming effect of maternal psychological distress leading to respiratory morbidity.</description><subject>Adult and adolescent clinical studies</subject><subject>Age</subject><subject>Allergy and Immunology</subject><subject>Anxiety</subject><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Body mass index</subject><subject>Breastfeeding & lactation</subject><subject>Child</subject><subject>child development</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>depression</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inventory</subject><subject>Male</subject><subject>Maternal Exposure - adverse effects</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mothers</subject><subject>Mothers - psychology</subject><subject>Paternal Exposure - adverse effects</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>preschool</subject><subject>Prospective Studies</subject><subject>psychological</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Questionnaires</subject><subject>Respiratory Sounds</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Stress</subject><subject>Stress, Psychological - epidemiology</subject><subject>Tobacco smoke</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGLEzEQxxdRvHr6BXyQBRF8aZ3ZJLuJHIIcegoHineCbyFNpm1622xNdpX105ul1YN7UBgIk_zmT2b-UxRPERYIWL_aLrbG-kUFyBbAc_B7xQxBNfNaVuJ-MQNQOK8brk6KRyltIedMqofFScWappGCz4qbzyZS6E1b7tNoN13brb3NmfOpj5RS6Ybow7rcR1oHE-xYmuDKnxuiX9O1D9NLyoVdW9qNb11We11eb6i8oEDR9L4L5Zfyqh_c-Lh4sDJtoifH87T4-v7d9fmH-eWni4_nby_nVkDVz5V0y4okF41rrKkcoJOKMVDgXK2EsGqF2CDWTBlEq9jKqqUDKRRwJHLstHh50N3H7vtAqdc7nyy1rQnUDUmjwDwULpT6P8oVNJLXvMro8zvothtiyI1kQdEgMCnrTFUHysYupUgrvY9-Z-KoEfTkmt7qyTU9uaaB5-C56NlReljuyP0t-WNTBl4cAZOyO6uYnfDplpPIhaghc2cHjvJ4f3iKOllPwZLzkWyvXef__Y83d8pt68O0Dzc0UrrtV6dKg76a9mtaL2QAtcJv7DcZPcmT</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Guxens, Mònica, MD, MPH, PhD</creator><creator>Sonnenschein–van der Voort, Agnes M.M., MSc</creator><creator>Tiemeier, Henning, MD, PhD</creator><creator>Hofman, Albert, MD, PhD</creator><creator>Sunyer, Jordi, MD, PhD</creator><creator>de Jongste, Johan C., MD, PhD</creator><creator>Jaddoe, Vincent W.V., MD, PhD</creator><creator>Duijts, Liesbeth, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study</title><author>Guxens, Mònica, MD, MPH, PhD ; Sonnenschein–van der Voort, Agnes M.M., MSc ; Tiemeier, Henning, MD, PhD ; Hofman, Albert, MD, PhD ; Sunyer, Jordi, MD, PhD ; de Jongste, Johan C., MD, PhD ; Jaddoe, Vincent W.V., MD, PhD ; Duijts, Liesbeth, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-98db2e8457d7ca2d01d8933090dd6955c9f11711639a11c93fc9bd0859041eed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Age</topic><topic>Allergy and Immunology</topic><topic>Anxiety</topic><topic>Asthma</topic><topic>Biological and medical sciences</topic><topic>Body mass index</topic><topic>Breastfeeding & lactation</topic><topic>Child</topic><topic>child development</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>depression</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Inventory</topic><topic>Male</topic><topic>Maternal Exposure - adverse effects</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mothers</topic><topic>Mothers - psychology</topic><topic>Paternal Exposure - adverse effects</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>preschool</topic><topic>Prospective Studies</topic><topic>psychological</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Questionnaires</topic><topic>Respiratory Sounds</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Stress</topic><topic>Stress, Psychological - epidemiology</topic><topic>Tobacco smoke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guxens, Mònica, MD, MPH, PhD</creatorcontrib><creatorcontrib>Sonnenschein–van der Voort, Agnes M.M., MSc</creatorcontrib><creatorcontrib>Tiemeier, Henning, MD, PhD</creatorcontrib><creatorcontrib>Hofman, Albert, MD, PhD</creatorcontrib><creatorcontrib>Sunyer, Jordi, MD, PhD</creatorcontrib><creatorcontrib>de Jongste, Johan C., MD, PhD</creatorcontrib><creatorcontrib>Jaddoe, Vincent W.V., MD, PhD</creatorcontrib><creatorcontrib>Duijts, Liesbeth, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guxens, Mònica, MD, MPH, PhD</au><au>Sonnenschein–van der Voort, Agnes M.M., MSc</au><au>Tiemeier, Henning, MD, PhD</au><au>Hofman, Albert, MD, PhD</au><au>Sunyer, Jordi, MD, PhD</au><au>de Jongste, Johan C., MD, PhD</au><au>Jaddoe, Vincent W.V., MD, PhD</au><au>Duijts, Liesbeth, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>133</volume><issue>1</issue><spage>59</spage><epage>67.e12</epage><pages>59-67.e12</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma. Objective We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing. Methods We performed a population-based prospective cohort study among 4848 children. We assessed maternal and paternal psychological distress at the second trimester of gestation and 3 years after delivery and maternal psychological distress at 2 and 6 months after delivery by using the Brief Symptom Inventory questionnaire. Wheezing in the children was annually examined by using questionnaires from 1 to 4 years. Physician-diagnosed ever asthma was reported at 6 years. Results Mothers with psychological distress during pregnancy had increased odds of wheezing in their children from 1 to 4 years of life (overall distress: odds ratio [OR], 1.60 [95% CI, 1.32-1.93]; depression: OR, 1.46 [95% CI, 1.20-1.77]; and anxiety: OR, 1.39 [95% CI, 1.15-1.67]). We observed similar positive associations with the number of wheezing episodes, wheezing patterns, and physician-diagnosed asthma at 6 years. Paternal distress during pregnancy and maternal and paternal distress after delivery did not affect these results and were not associated with childhood wheezing. Conclusion Maternal psychological distress during pregnancy is associated with increased odds of wheezing in their children during the first 6 years of life independent of paternal psychological distress during pregnancy and maternal and paternal psychological distress after delivery. These results suggest a possible intrauterine programming effect of maternal psychological distress leading to respiratory morbidity.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23777854</pmid><doi>10.1016/j.jaci.2013.04.044</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Age Allergy and Immunology Anxiety Asthma Biological and medical sciences Body mass index Breastfeeding & lactation Child child development Child, Preschool Cohort Studies depression Ethnicity Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunopathology Infant Infant, Newborn Inventory Male Maternal Exposure - adverse effects Medical sciences Miscellaneous Mothers Mothers - psychology Paternal Exposure - adverse effects Pregnancy Pregnancy Complications - epidemiology Prenatal Exposure Delayed Effects - epidemiology preschool Prospective Studies psychological Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Questionnaires Respiratory Sounds Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Stress Stress, Psychological - epidemiology Tobacco smoke |
| title | Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study |
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