Aging is associated with changes in the neural circuits underlying empathy
Abstract Although the neurodevelopment of empathy from childhood to adolescence has been documented, no study has yet examined it across a life span aging perspective. Sixty-five healthy participants from 3 age groups (young, middle-aged, old) underwent functional magnetic resonance imaging while pr...
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Veröffentlicht in: | Neurobiology of aging 2014-04, Vol.35 (4), p.827-836 |
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description | Abstract Although the neurodevelopment of empathy from childhood to adolescence has been documented, no study has yet examined it across a life span aging perspective. Sixty-five healthy participants from 3 age groups (young, middle-aged, old) underwent functional magnetic resonance imaging while presented with visual stimuli depicting body parts being injured, either accidentally by oneself or intentionally by another, thus isolating pain and agency as 2 variables of interest. Older adults reported less dispositional emotional empathy as assessed by the interpersonal reactivity index, and their unpleasantness ratings were more sensitive to intentional harm. The response in anterior insula and anterior mid-cingulate cortex to others' pain, indicative of emotional empathy, showed an age-related decline, whereas the response in medial prefrontal cortex and posterior superior temporal sulcus to perceived agency did not change with age. Dynamic causal modeling demonstrated that their effective connectivity remained stable. The pattern of hemodynamic response was not related to regional gray matter volume loss. These findings suggest that the neural response associated with emotional empathy lessened with age, whereas the response to perceived agency is preserved. |
doi_str_mv | 10.1016/j.neurobiolaging.2013.10.080 |
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Sixty-five healthy participants from 3 age groups (young, middle-aged, old) underwent functional magnetic resonance imaging while presented with visual stimuli depicting body parts being injured, either accidentally by oneself or intentionally by another, thus isolating pain and agency as 2 variables of interest. Older adults reported less dispositional emotional empathy as assessed by the interpersonal reactivity index, and their unpleasantness ratings were more sensitive to intentional harm. The response in anterior insula and anterior mid-cingulate cortex to others' pain, indicative of emotional empathy, showed an age-related decline, whereas the response in medial prefrontal cortex and posterior superior temporal sulcus to perceived agency did not change with age. Dynamic causal modeling demonstrated that their effective connectivity remained stable. The pattern of hemodynamic response was not related to regional gray matter volume loss. These findings suggest that the neural response associated with emotional empathy lessened with age, whereas the response to perceived agency is preserved.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2013.10.080</identifier><identifier>PMID: 24211010</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Agency ; Aging ; Aging - pathology ; Aging - psychology ; Dynamic causal modeling ; Effective connectivity ; Empathy ; Empathy - physiology ; Female ; Functional MRI ; Gray matter volume ; Gyrus Cinguli - pathology ; Gyrus Cinguli - physiology ; Humans ; Internal Medicine ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nerve Net - pathology ; Nerve Net - physiology ; Neurology ; Pain - psychology ; Photic Stimulation ; Wounds and Injuries - psychology ; Young Adult</subject><ispartof>Neurobiology of aging, 2014-04, Vol.35 (4), p.827-836</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-6758bf251ecdfd1b7a88e756f1bfdd32ed7265040c15c0b2503ca4ea4c94f2383</citedby><cites>FETCH-LOGICAL-c474t-6758bf251ecdfd1b7a88e756f1bfdd32ed7265040c15c0b2503ca4ea4c94f2383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2013.10.080$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24211010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yao-Chu</creatorcontrib><creatorcontrib>Chen, Cheng-Chiang</creatorcontrib><creatorcontrib>Decety, Jean</creatorcontrib><creatorcontrib>Cheng, Yawei</creatorcontrib><title>Aging is associated with changes in the neural circuits underlying empathy</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Although the neurodevelopment of empathy from childhood to adolescence has been documented, no study has yet examined it across a life span aging perspective. Sixty-five healthy participants from 3 age groups (young, middle-aged, old) underwent functional magnetic resonance imaging while presented with visual stimuli depicting body parts being injured, either accidentally by oneself or intentionally by another, thus isolating pain and agency as 2 variables of interest. Older adults reported less dispositional emotional empathy as assessed by the interpersonal reactivity index, and their unpleasantness ratings were more sensitive to intentional harm. The response in anterior insula and anterior mid-cingulate cortex to others' pain, indicative of emotional empathy, showed an age-related decline, whereas the response in medial prefrontal cortex and posterior superior temporal sulcus to perceived agency did not change with age. Dynamic causal modeling demonstrated that their effective connectivity remained stable. The pattern of hemodynamic response was not related to regional gray matter volume loss. These findings suggest that the neural response associated with emotional empathy lessened with age, whereas the response to perceived agency is preserved.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Agency</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Aging - psychology</subject><subject>Dynamic causal modeling</subject><subject>Effective connectivity</subject><subject>Empathy</subject><subject>Empathy - physiology</subject><subject>Female</subject><subject>Functional MRI</subject><subject>Gray matter volume</subject><subject>Gyrus Cinguli - pathology</subject><subject>Gyrus Cinguli - physiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Net - pathology</subject><subject>Nerve Net - physiology</subject><subject>Neurology</subject><subject>Pain - psychology</subject><subject>Photic Stimulation</subject><subject>Wounds and Injuries - psychology</subject><subject>Young Adult</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9rFDEYxoNY7Fr9CpJDD15m-yaTTLIgQimtVgoe1HPIJO_sZp3NrMmMZb99M2wV7MWe3sP7_IEfDyHnDJYMWHOxXUac0tCGobfrENdLDqwuryVoeEEWTEpdMbFSL8kC2EpVQmo4Ja9z3gKAEqp5RU654KyEwYJ8uZwzaMjU5jy4YEf09D6MG-o2Nq4x0xDpuEE6l9qeupDcFMZMp-gx9YfZjLu9HTeHN-Sks33Gt4_3jPy4uf5-9bm6-_rp9uryrnJCibFqlNRtxyVD5zvPWmW1RiWbjrWd9zVHr3gjQYBj0kHLJdTOCrTCrUTHa12fkffH3H0afk2YR7ML2WHf24jDlA2TrFGi5or_XypWUKq1FEX64Sh1acg5YWf2KexsOhgGZgZvtuZf8GYGP38L-GJ_99g0tTv0f81_SBfBzVGABc3vgMlkFzA69CGhG40fwnObPj4Jcn2Iwdn-Jx4wb4cpxYLfMJO5AfNtHsG8AVYDSKFF_QAdI7He</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Chen, Yao-Chu</creator><creator>Chen, Cheng-Chiang</creator><creator>Decety, Jean</creator><creator>Cheng, Yawei</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20140401</creationdate><title>Aging is associated with changes in the neural circuits underlying empathy</title><author>Chen, Yao-Chu ; Chen, Cheng-Chiang ; Decety, Jean ; Cheng, Yawei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-6758bf251ecdfd1b7a88e756f1bfdd32ed7265040c15c0b2503ca4ea4c94f2383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Agency</topic><topic>Aging</topic><topic>Aging - pathology</topic><topic>Aging - psychology</topic><topic>Dynamic causal modeling</topic><topic>Effective connectivity</topic><topic>Empathy</topic><topic>Empathy - physiology</topic><topic>Female</topic><topic>Functional MRI</topic><topic>Gray matter volume</topic><topic>Gyrus Cinguli - pathology</topic><topic>Gyrus Cinguli - physiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Net - pathology</topic><topic>Nerve Net - physiology</topic><topic>Neurology</topic><topic>Pain - psychology</topic><topic>Photic Stimulation</topic><topic>Wounds and Injuries - psychology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yao-Chu</creatorcontrib><creatorcontrib>Chen, Cheng-Chiang</creatorcontrib><creatorcontrib>Decety, Jean</creatorcontrib><creatorcontrib>Cheng, Yawei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yao-Chu</au><au>Chen, Cheng-Chiang</au><au>Decety, Jean</au><au>Cheng, Yawei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging is associated with changes in the neural circuits underlying empathy</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>35</volume><issue>4</issue><spage>827</spage><epage>836</epage><pages>827-836</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract Although the neurodevelopment of empathy from childhood to adolescence has been documented, no study has yet examined it across a life span aging perspective. Sixty-five healthy participants from 3 age groups (young, middle-aged, old) underwent functional magnetic resonance imaging while presented with visual stimuli depicting body parts being injured, either accidentally by oneself or intentionally by another, thus isolating pain and agency as 2 variables of interest. Older adults reported less dispositional emotional empathy as assessed by the interpersonal reactivity index, and their unpleasantness ratings were more sensitive to intentional harm. The response in anterior insula and anterior mid-cingulate cortex to others' pain, indicative of emotional empathy, showed an age-related decline, whereas the response in medial prefrontal cortex and posterior superior temporal sulcus to perceived agency did not change with age. Dynamic causal modeling demonstrated that their effective connectivity remained stable. The pattern of hemodynamic response was not related to regional gray matter volume loss. These findings suggest that the neural response associated with emotional empathy lessened with age, whereas the response to perceived agency is preserved.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24211010</pmid><doi>10.1016/j.neurobiolaging.2013.10.080</doi><tpages>10</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over Agency Aging Aging - pathology Aging - psychology Dynamic causal modeling Effective connectivity Empathy Empathy - physiology Female Functional MRI Gray matter volume Gyrus Cinguli - pathology Gyrus Cinguli - physiology Humans Internal Medicine Magnetic Resonance Imaging Male Middle Aged Nerve Net - pathology Nerve Net - physiology Neurology Pain - psychology Photic Stimulation Wounds and Injuries - psychology Young Adult |
title | Aging is associated with changes in the neural circuits underlying empathy |
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