A liposomal fluorescence assay to study permeation kinetics of drug-like weak bases across the lipid bilayer

Lipid bilayer permeation is considered the major route for in vivo barrier passage of drugs. Despite this fact, no technique is currently available to measure the kinetics of permeation across a single lipid bilayer of structurally unrelated drug-like solutes. We developed a liposomal fluorescence a...

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