Nanoparticle formulations of decoquinate increase antimalarial efficacy against liver stage Plasmodium infections in mice

Abstract Decoquinate has potent activity against both Plasmodium hepatic development and red cell replication when tested in vitro . Decoquinate, however, is practically insoluble in water. To achieve its maximal in vivo efficacy, we generated nanoparticle formulations of decoquinate with a mean par...

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Veröffentlicht in:	Nanomedicine 2014, Vol.10 (1), p.57-65
Hauptverfasser:	Wang, Hongxing, MD, Li, Qigui, PhD, Reyes, Sean, BSc, Zhang, Jing, BSc, Zeng, Qiang, MSc, Zhang, Ping, BSc, Xie, Lisa, PhD, Lee, Patricia J., BSc, Roncal, Norma, MSc, Melendez, Victor, PhD, Hickman, Mark, PhD, Kozar, Michael P., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antimalarials - administration & dosage Antimalarials - chemistry Causal prophylaxis Decoquinate - administration & dosage Decoquinate - chemistry Humans Internal Medicine Liver - drug effects Liver - parasitology Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Malarial life cycle Mice Nanoparticles - administration & dosage Nanoparticles - chemistry Parasite growth Particle size Plasmodium berghei Plasmodium berghei - drug effects Real time imaging
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