Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte
B cell activating factor (BAFF) and its receptors were regarded as elements of the immune system, regulating the fate of B cell. In recent years, these molecules were identified in a number of normal and pathological tissues, expanding their potential functions beyond the immune system. In this stud...
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| Veröffentlicht in: | International immunopharmacology 2014-02, Vol.18 (2), p.365-372 |
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| container_title | International immunopharmacology |
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| creator | Wu, Haitao Han, Dongju Jiang, Zhengan Zhao, Dongwei Liu, Meng Xu, Xingzhou Liu, Xia Yang, Lin Ji, Xuemei Wang, Mingyan Zhang, Shuangquan |
| description | B cell activating factor (BAFF) and its receptors were regarded as elements of the immune system, regulating the fate of B cell. In recent years, these molecules were identified in a number of normal and pathological tissues, expanding their potential functions beyond the immune system. In this study, on the basis of molecular clone and prokaryotic expression of equine BAFF, we reported that equine adipose-derived stem cell (ASC) expressed BAFF and its receptors, which exhibited the increased expression during ASC adipogenic differentiation in vitro. Moreover, with the addition of recombinant protein His6-sBAFF, an increased differentiation of equine ASC towards adipocyte was detected. These results suggested that BAFF and its receptors might be associated with the differentiation process of ASC towards adipocyte in horse.
•Equine ASC expresses BAFF and its receptors.•Equine BAFF and its receptors exhibit increased expression during ASC adipogenesis.•His6-sBAFF addition promotes equine ASC adipogenesis in vitro. |
| doi_str_mv | 10.1016/j.intimp.2013.12.018 |
| format | Article |
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•Equine ASC expresses BAFF and its receptors.•Equine BAFF and its receptors exhibit increased expression during ASC adipogenesis.•His6-sBAFF addition promotes equine ASC adipogenesis in vitro.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2013.12.018</identifier><identifier>PMID: 24389381</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adipocytes ; Adipogenic differentiation ; Adipose Tissue - cytology ; Adipose-derived stem cell ; Amino Acid Sequence ; Animals ; B-Cell Activating Factor - chemistry ; B-Cell Activating Factor - genetics ; B-Cell Activating Factor - metabolism ; B-Cell Activation Factor Receptor - genetics ; B-Cell Activation Factor Receptor - metabolism ; BAFF ; Cell Differentiation - physiology ; Equine ; Female ; Horse ; Horses ; Molecular Sequence Data ; Protein Structure, Secondary ; Stem Cells - cytology ; Stem Cells - metabolism</subject><ispartof>International immunopharmacology, 2014-02, Vol.18 (2), p.365-372</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-9ad1c2e1c67ce5d39b3a3e495b7af655aeb3b3b9fa4369657cce28c2d603427c3</citedby><cites>FETCH-LOGICAL-c395t-9ad1c2e1c67ce5d39b3a3e495b7af655aeb3b3b9fa4369657cce28c2d603427c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2013.12.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24389381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Haitao</creatorcontrib><creatorcontrib>Han, Dongju</creatorcontrib><creatorcontrib>Jiang, Zhengan</creatorcontrib><creatorcontrib>Zhao, Dongwei</creatorcontrib><creatorcontrib>Liu, Meng</creatorcontrib><creatorcontrib>Xu, Xingzhou</creatorcontrib><creatorcontrib>Liu, Xia</creatorcontrib><creatorcontrib>Yang, Lin</creatorcontrib><creatorcontrib>Ji, Xuemei</creatorcontrib><creatorcontrib>Wang, Mingyan</creatorcontrib><creatorcontrib>Zhang, Shuangquan</creatorcontrib><title>Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>B cell activating factor (BAFF) and its receptors were regarded as elements of the immune system, regulating the fate of B cell. In recent years, these molecules were identified in a number of normal and pathological tissues, expanding their potential functions beyond the immune system. In this study, on the basis of molecular clone and prokaryotic expression of equine BAFF, we reported that equine adipose-derived stem cell (ASC) expressed BAFF and its receptors, which exhibited the increased expression during ASC adipogenic differentiation in vitro. Moreover, with the addition of recombinant protein His6-sBAFF, an increased differentiation of equine ASC towards adipocyte was detected. These results suggested that BAFF and its receptors might be associated with the differentiation process of ASC towards adipocyte in horse.
•Equine ASC expresses BAFF and its receptors.•Equine BAFF and its receptors exhibit increased expression during ASC adipogenesis.•His6-sBAFF addition promotes equine ASC adipogenesis in vitro.</description><subject>Adipocytes</subject><subject>Adipogenic differentiation</subject><subject>Adipose Tissue - cytology</subject><subject>Adipose-derived stem cell</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>B-Cell Activating Factor - chemistry</subject><subject>B-Cell Activating Factor - genetics</subject><subject>B-Cell Activating Factor - metabolism</subject><subject>B-Cell Activation Factor Receptor - genetics</subject><subject>B-Cell Activation Factor Receptor - metabolism</subject><subject>BAFF</subject><subject>Cell Differentiation - physiology</subject><subject>Equine</subject><subject>Female</subject><subject>Horse</subject><subject>Horses</subject><subject>Molecular Sequence Data</subject><subject>Protein Structure, Secondary</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9uFCEYxSdGY2v1DYzhsiadkT8DDDcm66arJk28UK8JA99k2ewMU2C77qv4tGUz1UsNFxByvnMO_KrqLcENwUR82DV-yn6cG4oJawhtMOmeVZekk11NJObPy5kLWXMp1EX1KqUdxuW-JS-rC9qyTrGOXFa_b-8PfgJknJ9DgtpB9A_gUMowIgv7PbpefV-_R_BrjpASJPRptdkgMznkc0IRLMw5xHSDjltvt2g0J9QXu5SC9SYXp6PPW5S3gJwfBohQSpvsw4TmGGyxRGFAJQLlcDTRpaWJPWV4Xb0YzD7Bm6f9qvq5uf2x_lLfffv8db26qy1TPNfKOGIpECukBe6Y6plh0CreSzMIzg30rCw1mJYJJbi0FmhnqROYtVRadlVdL76l0P0BUtajT-enmwnCIWnCiZBMKYr_L20VFZ1gvC3SdpHaGFKKMOg5-tHEkyZYnwHqnV4A6jNATaguAMvYu6eEQz-C-zv0h1gRfFwEUL7kwUPUyXqYLDhfYGTtgv93wiP5CbAD</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Wu, Haitao</creator><creator>Han, Dongju</creator><creator>Jiang, Zhengan</creator><creator>Zhao, Dongwei</creator><creator>Liu, Meng</creator><creator>Xu, Xingzhou</creator><creator>Liu, Xia</creator><creator>Yang, Lin</creator><creator>Ji, Xuemei</creator><creator>Wang, Mingyan</creator><creator>Zhang, Shuangquan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201402</creationdate><title>Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte</title><author>Wu, Haitao ; Han, Dongju ; Jiang, Zhengan ; Zhao, Dongwei ; Liu, Meng ; Xu, Xingzhou ; Liu, Xia ; Yang, Lin ; Ji, Xuemei ; Wang, Mingyan ; Zhang, Shuangquan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-9ad1c2e1c67ce5d39b3a3e495b7af655aeb3b3b9fa4369657cce28c2d603427c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipocytes</topic><topic>Adipogenic differentiation</topic><topic>Adipose Tissue - cytology</topic><topic>Adipose-derived stem cell</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>B-Cell Activating Factor - chemistry</topic><topic>B-Cell Activating Factor - genetics</topic><topic>B-Cell Activating Factor - metabolism</topic><topic>B-Cell Activation Factor Receptor - genetics</topic><topic>B-Cell Activation Factor Receptor - metabolism</topic><topic>BAFF</topic><topic>Cell Differentiation - physiology</topic><topic>Equine</topic><topic>Female</topic><topic>Horse</topic><topic>Horses</topic><topic>Molecular Sequence Data</topic><topic>Protein Structure, Secondary</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Haitao</creatorcontrib><creatorcontrib>Han, Dongju</creatorcontrib><creatorcontrib>Jiang, Zhengan</creatorcontrib><creatorcontrib>Zhao, Dongwei</creatorcontrib><creatorcontrib>Liu, Meng</creatorcontrib><creatorcontrib>Xu, Xingzhou</creatorcontrib><creatorcontrib>Liu, Xia</creatorcontrib><creatorcontrib>Yang, Lin</creatorcontrib><creatorcontrib>Ji, Xuemei</creatorcontrib><creatorcontrib>Wang, Mingyan</creatorcontrib><creatorcontrib>Zhang, Shuangquan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Haitao</au><au>Han, Dongju</au><au>Jiang, Zhengan</au><au>Zhao, Dongwei</au><au>Liu, Meng</au><au>Xu, Xingzhou</au><au>Liu, Xia</au><au>Yang, Lin</au><au>Ji, Xuemei</au><au>Wang, Mingyan</au><au>Zhang, Shuangquan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2014-02</date><risdate>2014</risdate><volume>18</volume><issue>2</issue><spage>365</spage><epage>372</epage><pages>365-372</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>B cell activating factor (BAFF) and its receptors were regarded as elements of the immune system, regulating the fate of B cell. In recent years, these molecules were identified in a number of normal and pathological tissues, expanding their potential functions beyond the immune system. In this study, on the basis of molecular clone and prokaryotic expression of equine BAFF, we reported that equine adipose-derived stem cell (ASC) expressed BAFF and its receptors, which exhibited the increased expression during ASC adipogenic differentiation in vitro. Moreover, with the addition of recombinant protein His6-sBAFF, an increased differentiation of equine ASC towards adipocyte was detected. These results suggested that BAFF and its receptors might be associated with the differentiation process of ASC towards adipocyte in horse.
•Equine ASC expresses BAFF and its receptors.•Equine BAFF and its receptors exhibit increased expression during ASC adipogenesis.•His6-sBAFF addition promotes equine ASC adipogenesis in vitro.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24389381</pmid><doi>10.1016/j.intimp.2013.12.018</doi><tpages>8</tpages></addata></record> |
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| subjects | Adipocytes Adipogenic differentiation Adipose Tissue - cytology Adipose-derived stem cell Amino Acid Sequence Animals B-Cell Activating Factor - chemistry B-Cell Activating Factor - genetics B-Cell Activating Factor - metabolism B-Cell Activation Factor Receptor - genetics B-Cell Activation Factor Receptor - metabolism BAFF Cell Differentiation - physiology Equine Female Horse Horses Molecular Sequence Data Protein Structure, Secondary Stem Cells - cytology Stem Cells - metabolism |
| title | Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte |
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