Inhibitory effect of 9-hydroxy-6,7-dimethoxydalbergiquinol from Dalbergia odorifera on the NF-κB-related neuroinflammatory response in lipopolysaccharide-stimulated mouse BV2 microglial cells is mediated by heme oxygenase-1

The heartwood of Dalbergia odorifera T. Chen (Leguminosae) is an important source of traditional Korean and Chinese medicines. 9-Hydroxy-6,7-dimethoxydalbergiquinol (HDDQ), a compound isolated from D. odorifera, has various biological activities. The aim of this study was to determine the efficacy o...

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Veröffentlicht in:	International immunopharmacology 2013-11, Vol.17 (3), p.828-835
Hauptverfasser:	Lee, Dong-Sung, Li, Bin, Keo, Samell, Kim, Kyoung-Su, Jeong, Gil-Saeng, Oh, Hyuncheol, Kim, Youn-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	9-hydroxy-6,7-dimethoxydalbergiquinol Allyl Compounds - pharmacology Animals Anisoles - pharmacology Anti-Inflammatory Agents - pharmacology BV2 microglia Cell Line Dalbergia Dalbergia odorifera Dinoprostone - metabolism Heme oxygenase-1 Heme Oxygenase-1 - metabolism Interleukin-1beta - metabolism Lipopolysaccharides Membrane Proteins - metabolism Mice Microglia - drug effects Microglia - metabolism Neuroinflammation Neuroprotective Agents - pharmacology NF-E2-Related Factor 2 - metabolism NF-kappa B - antagonists & inhibitors Nitric Oxide - metabolism Nuclear factor kappa B Tumor Necrosis Factor-alpha - metabolism
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