Production of Indirubin from Tryptophan by Recombinant Escherichia coli Containing Naphthalene Dioxygenase Genes from Comamonas sp. MQ

Indirubin, a red isomer of indigo, can be used for the treatment of various chronic diseases. However, the microbial production of indirubin did not receive much attention probably due to its low yield compared with indigo. In this study, the recombinant Escherichia coli containing the naphthalene d...

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Veröffentlicht in:	Applied biochemistry and biotechnology 2014-03, Vol.172 (6), p.3194-3206
Hauptverfasser:	Zhang, Xuwang, Qu, Yuanyuan, Ma, Qiao, Kong, Chunlei, Zhou, Hao, Cao, Xiangyu, Shen, Wenli, Shen, E, Zhou, Jiti
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Biochemistry Biological and medical sciences Biotechnology Chemistry Chemistry and Materials Science chronic diseases Comamonas Comamonas - chemistry Comamonas - enzymology Dioxygenases - biosynthesis Dioxygenases - genetics E coli Enzyme Induction Enzymes Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Factor Analysis, Statistical Fundamental and applied biological sciences. Psychology Gene Expression Genes Indoles - metabolism Indoles - pharmacology Isatin - pharmacology Isopropyl Thiogalactoside - pharmacology Multienzyme Complexes - biosynthesis Multienzyme Complexes - genetics Naphthalene Recombinant Proteins - biosynthesis Recombinant Proteins - genetics response surface methodology tryptophan Tryptophan - metabolism
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