Periprocedural Glycemic Control in Patients With Diabetes Mellitus Undergoing Coronary Angiography With Possible Percutaneous Coronary Intervention
Periprocedural hyperglycemia is an independent predictor of mortality in patients who underwent percutaneous coronary intervention (PCI). However, periprocedural management of blood glucose is not standardized. The effects of routinely continuing long-acting glucose-lowering medications before coron...
Gespeichert in:
| Veröffentlicht in: | The American journal of cardiology 2014-05, Vol.113 (9), p.1474-1480 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1480 |
|---|---|
| container_issue | 9 |
| container_start_page | 1474 |
| container_title | The American journal of cardiology |
| container_volume | 113 |
| creator | Shah, Binita, MD, MS Berger, Jeffrey S., MD, MS Amoroso, Nicholas S., MD Mai, Xingchen, BS Lorin, Jeffrey D., MD Danoff, Ann, MD Schwartzbard, Arthur Z., MD Lobach, Iryna, PhD Guo, Yu, MA Feit, Frederick, MD Slater, James, MD Attubato, Michael J., MD Sedlis, Steven P., MD |
| description | Periprocedural hyperglycemia is an independent predictor of mortality in patients who underwent percutaneous coronary intervention (PCI). However, periprocedural management of blood glucose is not standardized. The effects of routinely continuing long-acting glucose-lowering medications before coronary angiography with possible PCI on periprocedural glycemic control have not been investigated. Patients with diabetes mellitus (DM; n = 172) were randomized to continue (Continue group; n = 86) or hold (Hold group; n = 86) their clinically prescribed long-acting glucose-lowering medications before the procedure. The primary end point was glucose level on procedural access. In a subset of patients (no DM group: n = 25; Continue group: n = 25; and Hold group: n = 25), selected measures of platelet activity that change acutely were assessed. Patients with DM randomized to the Continue group had lower blood glucose levels on procedural access compared with those randomized to the Hold group (117 [97 to 151] vs 134 [117 to 172] mg/dl, p = 0.002). There were two hypoglycemic events in the Continue group and none in the Hold group, and no adverse events in either group. Selected markers of platelet activity differed across the no DM, Continue, and Hold groups (leukocyte platelet aggregates: 8.1% [7.2 to 10.4], 8.7% [6.9 to 11.4], 10.9% [8.6 to 14.7], p = 0.007; monocyte platelet aggregates: 14.0% [10.3 to 16.3], 20.8% [16.2 to 27.0], 22.5% [15.2 to 35.4], p |
| doi_str_mv | 10.1016/j.amjcard.2014.01.428 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1516730124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0002914914006274</els_id><sourcerecordid>1516730124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-ffca2fbfdbde940097985296b20b4d3000eca60a948121465a573f2144539e193</originalsourceid><addsrcrecordid>eNqFksFu1DAQhiMEokvhEUCRuHDZ4HGcZH0BVQuUSkWsBBVHy3EmWy9Ze7GdSvscvDATZSlSL5xsS98_M__8zrKXwApgUL_dFXq_Mzp0BWcgCgaF4KtH2QJWjVyChPJxtmCM8aUEIc-yZzHu6AlQ1U-zMy7qkjUSFtnvDQZ7CN5gNwY95JfD0eDemnztXQp-yK3LNzpZdCnmP2y6zT9Y3WLCmH_BYbBpjPmN6zBsvXVbUgXvdDjmF25r_Tbow-1xlm18jLYdMKeGZkzaoSfpPX_lEoY76mK9e5496fUQ8cXpPM9uPn38vv68vP56ebW-uF4aIau07Hujed_2XduhFIzJRq4qLuuWs1Z0JblFo2umpVgBB1FXumrKnm6iKiWCLM-zN3Nd8v9rxJjU3kZDrubhFFRQNyUDLgh9_QDd-TE4mm6iVgA1E0BUNVMmkNuAvToEuyd7CpiaUlM7dUpNTakpBopSI92rU_Wx3WN3r_obEwHvZwBpHXcWg4qGIqHQbECTVOftf1u8e1DBDNZZo4efeMT4z42KXDH1bfo6088BWmzNG1H-AXV4wf8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1518116041</pqid></control><display><type>article</type><title>Periprocedural Glycemic Control in Patients With Diabetes Mellitus Undergoing Coronary Angiography With Possible Percutaneous Coronary Intervention</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Shah, Binita, MD, MS ; Berger, Jeffrey S., MD, MS ; Amoroso, Nicholas S., MD ; Mai, Xingchen, BS ; Lorin, Jeffrey D., MD ; Danoff, Ann, MD ; Schwartzbard, Arthur Z., MD ; Lobach, Iryna, PhD ; Guo, Yu, MA ; Feit, Frederick, MD ; Slater, James, MD ; Attubato, Michael J., MD ; Sedlis, Steven P., MD</creator><creatorcontrib>Shah, Binita, MD, MS ; Berger, Jeffrey S., MD, MS ; Amoroso, Nicholas S., MD ; Mai, Xingchen, BS ; Lorin, Jeffrey D., MD ; Danoff, Ann, MD ; Schwartzbard, Arthur Z., MD ; Lobach, Iryna, PhD ; Guo, Yu, MA ; Feit, Frederick, MD ; Slater, James, MD ; Attubato, Michael J., MD ; Sedlis, Steven P., MD</creatorcontrib><description>Periprocedural hyperglycemia is an independent predictor of mortality in patients who underwent percutaneous coronary intervention (PCI). However, periprocedural management of blood glucose is not standardized. The effects of routinely continuing long-acting glucose-lowering medications before coronary angiography with possible PCI on periprocedural glycemic control have not been investigated. Patients with diabetes mellitus (DM; n = 172) were randomized to continue (Continue group; n = 86) or hold (Hold group; n = 86) their clinically prescribed long-acting glucose-lowering medications before the procedure. The primary end point was glucose level on procedural access. In a subset of patients (no DM group: n = 25; Continue group: n = 25; and Hold group: n = 25), selected measures of platelet activity that change acutely were assessed. Patients with DM randomized to the Continue group had lower blood glucose levels on procedural access compared with those randomized to the Hold group (117 [97 to 151] vs 134 [117 to 172] mg/dl, p = 0.002). There were two hypoglycemic events in the Continue group and none in the Hold group, and no adverse events in either group. Selected markers of platelet activity differed across the no DM, Continue, and Hold groups (leukocyte platelet aggregates: 8.1% [7.2 to 10.4], 8.7% [6.9 to 11.4], 10.9% [8.6 to 14.7], p = 0.007; monocyte platelet aggregates: 14.0% [10.3 to 16.3], 20.8% [16.2 to 27.0], 22.5% [15.2 to 35.4], p <0.001; soluble p-selectin: 51.9 ng/ml [39.7 to 74.0], 59.1 ng/ml [46.8 to 73.2], 72.2 ng/ml [58.4 to 77.4], p = 0.014). In conclusion, routinely continuing clinically prescribed long-acting glucose-lowering medications before coronary angiography with possible PCI help achieve periprocedural euglycemia, appear safe, and should be considered as a strategy for achieving periprocedural glycemic control.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2014.01.428</identifier><identifier>PMID: 24630791</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute coronary syndromes ; Aged ; Aspirin ; Blood Glucose - analysis ; Blood platelets ; Blood Platelets - physiology ; Cardiovascular ; Cholesterol ; Confidence intervals ; Coronary Angiography ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - therapy ; Drug therapy ; Female ; Humans ; Hyperglycemia ; Lipoproteins ; Male ; Medical imaging ; Middle Aged ; Mortality ; Percutaneous Coronary Intervention ; Preoperative Period ; Veterans</subject><ispartof>The American journal of cardiology, 2014-05, Vol.113 (9), p.1474-1480</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited May 1, 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-ffca2fbfdbde940097985296b20b4d3000eca60a948121465a573f2144539e193</citedby><cites>FETCH-LOGICAL-c495t-ffca2fbfdbde940097985296b20b4d3000eca60a948121465a573f2144539e193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1518116041?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24630791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shah, Binita, MD, MS</creatorcontrib><creatorcontrib>Berger, Jeffrey S., MD, MS</creatorcontrib><creatorcontrib>Amoroso, Nicholas S., MD</creatorcontrib><creatorcontrib>Mai, Xingchen, BS</creatorcontrib><creatorcontrib>Lorin, Jeffrey D., MD</creatorcontrib><creatorcontrib>Danoff, Ann, MD</creatorcontrib><creatorcontrib>Schwartzbard, Arthur Z., MD</creatorcontrib><creatorcontrib>Lobach, Iryna, PhD</creatorcontrib><creatorcontrib>Guo, Yu, MA</creatorcontrib><creatorcontrib>Feit, Frederick, MD</creatorcontrib><creatorcontrib>Slater, James, MD</creatorcontrib><creatorcontrib>Attubato, Michael J., MD</creatorcontrib><creatorcontrib>Sedlis, Steven P., MD</creatorcontrib><title>Periprocedural Glycemic Control in Patients With Diabetes Mellitus Undergoing Coronary Angiography With Possible Percutaneous Coronary Intervention</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Periprocedural hyperglycemia is an independent predictor of mortality in patients who underwent percutaneous coronary intervention (PCI). However, periprocedural management of blood glucose is not standardized. The effects of routinely continuing long-acting glucose-lowering medications before coronary angiography with possible PCI on periprocedural glycemic control have not been investigated. Patients with diabetes mellitus (DM; n = 172) were randomized to continue (Continue group; n = 86) or hold (Hold group; n = 86) their clinically prescribed long-acting glucose-lowering medications before the procedure. The primary end point was glucose level on procedural access. In a subset of patients (no DM group: n = 25; Continue group: n = 25; and Hold group: n = 25), selected measures of platelet activity that change acutely were assessed. Patients with DM randomized to the Continue group had lower blood glucose levels on procedural access compared with those randomized to the Hold group (117 [97 to 151] vs 134 [117 to 172] mg/dl, p = 0.002). There were two hypoglycemic events in the Continue group and none in the Hold group, and no adverse events in either group. Selected markers of platelet activity differed across the no DM, Continue, and Hold groups (leukocyte platelet aggregates: 8.1% [7.2 to 10.4], 8.7% [6.9 to 11.4], 10.9% [8.6 to 14.7], p = 0.007; monocyte platelet aggregates: 14.0% [10.3 to 16.3], 20.8% [16.2 to 27.0], 22.5% [15.2 to 35.4], p <0.001; soluble p-selectin: 51.9 ng/ml [39.7 to 74.0], 59.1 ng/ml [46.8 to 73.2], 72.2 ng/ml [58.4 to 77.4], p = 0.014). In conclusion, routinely continuing clinically prescribed long-acting glucose-lowering medications before coronary angiography with possible PCI help achieve periprocedural euglycemia, appear safe, and should be considered as a strategy for achieving periprocedural glycemic control.</description><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Aspirin</subject><subject>Blood Glucose - analysis</subject><subject>Blood platelets</subject><subject>Blood Platelets - physiology</subject><subject>Cardiovascular</subject><subject>Cholesterol</subject><subject>Confidence intervals</subject><subject>Coronary Angiography</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Percutaneous Coronary Intervention</subject><subject>Preoperative Period</subject><subject>Veterans</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFksFu1DAQhiMEokvhEUCRuHDZ4HGcZH0BVQuUSkWsBBVHy3EmWy9Ze7GdSvscvDATZSlSL5xsS98_M__8zrKXwApgUL_dFXq_Mzp0BWcgCgaF4KtH2QJWjVyChPJxtmCM8aUEIc-yZzHu6AlQ1U-zMy7qkjUSFtnvDQZ7CN5gNwY95JfD0eDemnztXQp-yK3LNzpZdCnmP2y6zT9Y3WLCmH_BYbBpjPmN6zBsvXVbUgXvdDjmF25r_Tbow-1xlm18jLYdMKeGZkzaoSfpPX_lEoY76mK9e5496fUQ8cXpPM9uPn38vv68vP56ebW-uF4aIau07Hujed_2XduhFIzJRq4qLuuWs1Z0JblFo2umpVgBB1FXumrKnm6iKiWCLM-zN3Nd8v9rxJjU3kZDrubhFFRQNyUDLgh9_QDd-TE4mm6iVgA1E0BUNVMmkNuAvToEuyd7CpiaUlM7dUpNTakpBopSI92rU_Wx3WN3r_obEwHvZwBpHXcWg4qGIqHQbECTVOftf1u8e1DBDNZZo4efeMT4z42KXDH1bfo6088BWmzNG1H-AXV4wf8</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Shah, Binita, MD, MS</creator><creator>Berger, Jeffrey S., MD, MS</creator><creator>Amoroso, Nicholas S., MD</creator><creator>Mai, Xingchen, BS</creator><creator>Lorin, Jeffrey D., MD</creator><creator>Danoff, Ann, MD</creator><creator>Schwartzbard, Arthur Z., MD</creator><creator>Lobach, Iryna, PhD</creator><creator>Guo, Yu, MA</creator><creator>Feit, Frederick, MD</creator><creator>Slater, James, MD</creator><creator>Attubato, Michael J., MD</creator><creator>Sedlis, Steven P., MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Periprocedural Glycemic Control in Patients With Diabetes Mellitus Undergoing Coronary Angiography With Possible Percutaneous Coronary Intervention</title><author>Shah, Binita, MD, MS ; Berger, Jeffrey S., MD, MS ; Amoroso, Nicholas S., MD ; Mai, Xingchen, BS ; Lorin, Jeffrey D., MD ; Danoff, Ann, MD ; Schwartzbard, Arthur Z., MD ; Lobach, Iryna, PhD ; Guo, Yu, MA ; Feit, Frederick, MD ; Slater, James, MD ; Attubato, Michael J., MD ; Sedlis, Steven P., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-ffca2fbfdbde940097985296b20b4d3000eca60a948121465a573f2144539e193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Aspirin</topic><topic>Blood Glucose - analysis</topic><topic>Blood platelets</topic><topic>Blood Platelets - physiology</topic><topic>Cardiovascular</topic><topic>Cholesterol</topic><topic>Confidence intervals</topic><topic>Coronary Angiography</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Percutaneous Coronary Intervention</topic><topic>Preoperative Period</topic><topic>Veterans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shah, Binita, MD, MS</creatorcontrib><creatorcontrib>Berger, Jeffrey S., MD, MS</creatorcontrib><creatorcontrib>Amoroso, Nicholas S., MD</creatorcontrib><creatorcontrib>Mai, Xingchen, BS</creatorcontrib><creatorcontrib>Lorin, Jeffrey D., MD</creatorcontrib><creatorcontrib>Danoff, Ann, MD</creatorcontrib><creatorcontrib>Schwartzbard, Arthur Z., MD</creatorcontrib><creatorcontrib>Lobach, Iryna, PhD</creatorcontrib><creatorcontrib>Guo, Yu, MA</creatorcontrib><creatorcontrib>Feit, Frederick, MD</creatorcontrib><creatorcontrib>Slater, James, MD</creatorcontrib><creatorcontrib>Attubato, Michael J., MD</creatorcontrib><creatorcontrib>Sedlis, Steven P., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library (ProQuest)</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shah, Binita, MD, MS</au><au>Berger, Jeffrey S., MD, MS</au><au>Amoroso, Nicholas S., MD</au><au>Mai, Xingchen, BS</au><au>Lorin, Jeffrey D., MD</au><au>Danoff, Ann, MD</au><au>Schwartzbard, Arthur Z., MD</au><au>Lobach, Iryna, PhD</au><au>Guo, Yu, MA</au><au>Feit, Frederick, MD</au><au>Slater, James, MD</au><au>Attubato, Michael J., MD</au><au>Sedlis, Steven P., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periprocedural Glycemic Control in Patients With Diabetes Mellitus Undergoing Coronary Angiography With Possible Percutaneous Coronary Intervention</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>113</volume><issue>9</issue><spage>1474</spage><epage>1480</epage><pages>1474-1480</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Periprocedural hyperglycemia is an independent predictor of mortality in patients who underwent percutaneous coronary intervention (PCI). However, periprocedural management of blood glucose is not standardized. The effects of routinely continuing long-acting glucose-lowering medications before coronary angiography with possible PCI on periprocedural glycemic control have not been investigated. Patients with diabetes mellitus (DM; n = 172) were randomized to continue (Continue group; n = 86) or hold (Hold group; n = 86) their clinically prescribed long-acting glucose-lowering medications before the procedure. The primary end point was glucose level on procedural access. In a subset of patients (no DM group: n = 25; Continue group: n = 25; and Hold group: n = 25), selected measures of platelet activity that change acutely were assessed. Patients with DM randomized to the Continue group had lower blood glucose levels on procedural access compared with those randomized to the Hold group (117 [97 to 151] vs 134 [117 to 172] mg/dl, p = 0.002). There were two hypoglycemic events in the Continue group and none in the Hold group, and no adverse events in either group. Selected markers of platelet activity differed across the no DM, Continue, and Hold groups (leukocyte platelet aggregates: 8.1% [7.2 to 10.4], 8.7% [6.9 to 11.4], 10.9% [8.6 to 14.7], p = 0.007; monocyte platelet aggregates: 14.0% [10.3 to 16.3], 20.8% [16.2 to 27.0], 22.5% [15.2 to 35.4], p <0.001; soluble p-selectin: 51.9 ng/ml [39.7 to 74.0], 59.1 ng/ml [46.8 to 73.2], 72.2 ng/ml [58.4 to 77.4], p = 0.014). In conclusion, routinely continuing clinically prescribed long-acting glucose-lowering medications before coronary angiography with possible PCI help achieve periprocedural euglycemia, appear safe, and should be considered as a strategy for achieving periprocedural glycemic control.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24630791</pmid><doi>10.1016/j.amjcard.2014.01.428</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 2014-05, Vol.113 (9), p.1474-1480 |
| issn | 0002-9149 1879-1913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1516730124 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Acute coronary syndromes Aged Aspirin Blood Glucose - analysis Blood platelets Blood Platelets - physiology Cardiovascular Cholesterol Confidence intervals Coronary Angiography Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - therapy Drug therapy Female Humans Hyperglycemia Lipoproteins Male Medical imaging Middle Aged Mortality Percutaneous Coronary Intervention Preoperative Period Veterans |
| title | Periprocedural Glycemic Control in Patients With Diabetes Mellitus Undergoing Coronary Angiography With Possible Percutaneous Coronary Intervention |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T20%3A48%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Periprocedural%20Glycemic%20Control%20in%20Patients%20With%20Diabetes%20Mellitus%20Undergoing%20Coronary%20Angiography%20With%20Possible%20Percutaneous%20Coronary%20Intervention&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Shah,%20Binita,%20MD,%20MS&rft.date=2014-05-01&rft.volume=113&rft.issue=9&rft.spage=1474&rft.epage=1480&rft.pages=1474-1480&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/j.amjcard.2014.01.428&rft_dat=%3Cproquest_cross%3E1516730124%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1518116041&rft_id=info:pmid/24630791&rft_els_id=1_s2_0_S0002914914006274&rfr_iscdi=true |