Treatment and outcome of young patients with esophageal cancer in the Netherlands
Background Esophageal cancer is increasingly recognized in younger patients. We compared clinicopathological characteristics, treatment, and survival of patients aged ≤50 years with patients aged >50 years diagnosed with esophageal cancer in the Netherlands. Methods From the nationwide Netherland...
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| Veröffentlicht in: | Journal of surgical oncology 2014-05, Vol.109 (6), p.561-566 |
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| creator | van Nistelrooij, Anna M.J. van Steenbergen, Liza N. Spaander, Manon C.W. Tilanus, Hugo W. van Lanschot, J. Jan B. Lemmens, Valery E.P.P. Wijnhoven, Bas P.L. |
| description | Background
Esophageal cancer is increasingly recognized in younger patients. We compared clinicopathological characteristics, treatment, and survival of patients aged ≤50 years with patients aged >50 years diagnosed with esophageal cancer in the Netherlands.
Methods
From the nationwide Netherlands Cancer Registry we identified all patients diagnosed with esophageal cancer between January 2000 and January 2011. Proportions were compared using the χ2 test for categorical variables. Overall and relative survival was calculated.
Results
Eleven percent of the patients (n = 1,466) were aged ≤50 years and adenocarcinoma was the most common tumor type (73.6%). Grade of tumor differentiation was comparable between both age groups (P = 0.460) as well as T‐stage (P = 0.058). Younger patients presented more often with positive lymph nodes (70.1% vs. 66.4%, P = 0.010) and distant metastasis (50.5% vs. 44.7%, P 0.05. A subgroup analysis among patients diagnosed with adenocarcinoma revealed similar results.
Conclusions
Young patients with esophageal cancer present with more advanced disease stage and received more often treatment. However, they show comparable relative survival rates with their older counterparts. J. Surg. Oncol. 2014 109:561–566. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jso.23533 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1516724450</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3274866691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4263-63a0b14b7c375a2df171d7dcd7230d55ea712159a7a43b9cdbc10aa3c1b56d613</originalsourceid><addsrcrecordid>eNp1kMtO3DAUQK2qVRloF_wAstQNLAJ-O1kiyqNlCkJM1aXl2HeYDEk8tRPB_D2mAyyQurEX99yjq4PQLiWHlBB2tEzhkHHJ-Qc0oaRSRUWq8iOa5BkrhK7IFtpOaUkIqSolPqMtJjgvlSITdDOLYIcO-gHb3uMwDi50gMMcr8PY3-GVHZo8TPihGRYYUlgt7B3YFjvbO4i46fGwAHwF-Y1tVqQv6NPctgm-vvw76PfZ6ezkophen_84OZ4WTjDFC8UtqamoteNaWubnVFOvvfOaceKlBKspo7Ky2gpeV87XjhJruaO1VF5RvoP2N95VDH9HSIPpmuSgzUdAGJOhkirNhJAko9_eocswxj5f90zJsuSlEJk62FAuhpQizM0qNp2Na0OJee5scmfzr3Nm916MY92BfyNfw2bgaAM8NC2s_28yP2-vX5XFZqNJAzy-bdh4b5TOjcyfq3NDfvGb2--XMzPlT1ImlZ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1515883844</pqid></control><display><type>article</type><title>Treatment and outcome of young patients with esophageal cancer in the Netherlands</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>van Nistelrooij, Anna M.J. ; van Steenbergen, Liza N. ; Spaander, Manon C.W. ; Tilanus, Hugo W. ; van Lanschot, J. Jan B. ; Lemmens, Valery E.P.P. ; Wijnhoven, Bas P.L.</creator><creatorcontrib>van Nistelrooij, Anna M.J. ; van Steenbergen, Liza N. ; Spaander, Manon C.W. ; Tilanus, Hugo W. ; van Lanschot, J. Jan B. ; Lemmens, Valery E.P.P. ; Wijnhoven, Bas P.L.</creatorcontrib><description>Background
Esophageal cancer is increasingly recognized in younger patients. We compared clinicopathological characteristics, treatment, and survival of patients aged ≤50 years with patients aged >50 years diagnosed with esophageal cancer in the Netherlands.
Methods
From the nationwide Netherlands Cancer Registry we identified all patients diagnosed with esophageal cancer between January 2000 and January 2011. Proportions were compared using the χ2 test for categorical variables. Overall and relative survival was calculated.
Results
Eleven percent of the patients (n = 1,466) were aged ≤50 years and adenocarcinoma was the most common tumor type (73.6%). Grade of tumor differentiation was comparable between both age groups (P = 0.460) as well as T‐stage (P = 0.058). Younger patients presented more often with positive lymph nodes (70.1% vs. 66.4%, P = 0.010) and distant metastasis (50.5% vs. 44.7%, P < 0.001) but had surgery more often as compared to older patients: 40.6% versus 37.9%, P = 0.047. There was no significant difference in the 5‐year relative survival between both age groups: 18.1% versus 17.2%, P > 0.05. A subgroup analysis among patients diagnosed with adenocarcinoma revealed similar results.
Conclusions
Young patients with esophageal cancer present with more advanced disease stage and received more often treatment. However, they show comparable relative survival rates with their older counterparts. J. Surg. Oncol. 2014 109:561–566. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23533</identifier><identifier>PMID: 24338660</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - therapy ; Age Factors ; Aged ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Esophageal cancer ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - therapy ; Esophagectomy - statistics & numerical data ; Female ; Health risk assessment ; Humans ; Lymphatic Metastasis ; Male ; Medical research ; Middle Aged ; Neoadjuvant Therapy - statistics & numerical data ; Neoplasm Staging ; Netherlands ; Palliative Care - statistics & numerical data ; Proportional Hazards Models ; Registries ; Sex Factors ; surgical treatment ; young patients</subject><ispartof>Journal of surgical oncology, 2014-05, Vol.109 (6), p.561-566</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4263-63a0b14b7c375a2df171d7dcd7230d55ea712159a7a43b9cdbc10aa3c1b56d613</citedby><cites>FETCH-LOGICAL-c4263-63a0b14b7c375a2df171d7dcd7230d55ea712159a7a43b9cdbc10aa3c1b56d613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.23533$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.23533$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24338660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Nistelrooij, Anna M.J.</creatorcontrib><creatorcontrib>van Steenbergen, Liza N.</creatorcontrib><creatorcontrib>Spaander, Manon C.W.</creatorcontrib><creatorcontrib>Tilanus, Hugo W.</creatorcontrib><creatorcontrib>van Lanschot, J. Jan B.</creatorcontrib><creatorcontrib>Lemmens, Valery E.P.P.</creatorcontrib><creatorcontrib>Wijnhoven, Bas P.L.</creatorcontrib><title>Treatment and outcome of young patients with esophageal cancer in the Netherlands</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background
Esophageal cancer is increasingly recognized in younger patients. We compared clinicopathological characteristics, treatment, and survival of patients aged ≤50 years with patients aged >50 years diagnosed with esophageal cancer in the Netherlands.
Methods
From the nationwide Netherlands Cancer Registry we identified all patients diagnosed with esophageal cancer between January 2000 and January 2011. Proportions were compared using the χ2 test for categorical variables. Overall and relative survival was calculated.
Results
Eleven percent of the patients (n = 1,466) were aged ≤50 years and adenocarcinoma was the most common tumor type (73.6%). Grade of tumor differentiation was comparable between both age groups (P = 0.460) as well as T‐stage (P = 0.058). Younger patients presented more often with positive lymph nodes (70.1% vs. 66.4%, P = 0.010) and distant metastasis (50.5% vs. 44.7%, P < 0.001) but had surgery more often as compared to older patients: 40.6% versus 37.9%, P = 0.047. There was no significant difference in the 5‐year relative survival between both age groups: 18.1% versus 17.2%, P > 0.05. A subgroup analysis among patients diagnosed with adenocarcinoma revealed similar results.
Conclusions
Young patients with esophageal cancer present with more advanced disease stage and received more often treatment. However, they show comparable relative survival rates with their older counterparts. J. Surg. Oncol. 2014 109:561–566. © 2013 Wiley Periodicals, Inc.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - therapy</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>Esophagectomy - statistics & numerical data</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy - statistics & numerical data</subject><subject>Neoplasm Staging</subject><subject>Netherlands</subject><subject>Palliative Care - statistics & numerical data</subject><subject>Proportional Hazards Models</subject><subject>Registries</subject><subject>Sex Factors</subject><subject>surgical treatment</subject><subject>young patients</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtO3DAUQK2qVRloF_wAstQNLAJ-O1kiyqNlCkJM1aXl2HeYDEk8tRPB_D2mAyyQurEX99yjq4PQLiWHlBB2tEzhkHHJ-Qc0oaRSRUWq8iOa5BkrhK7IFtpOaUkIqSolPqMtJjgvlSITdDOLYIcO-gHb3uMwDi50gMMcr8PY3-GVHZo8TPihGRYYUlgt7B3YFjvbO4i46fGwAHwF-Y1tVqQv6NPctgm-vvw76PfZ6ezkophen_84OZ4WTjDFC8UtqamoteNaWubnVFOvvfOaceKlBKspo7Ky2gpeV87XjhJruaO1VF5RvoP2N95VDH9HSIPpmuSgzUdAGJOhkirNhJAko9_eocswxj5f90zJsuSlEJk62FAuhpQizM0qNp2Na0OJee5scmfzr3Nm916MY92BfyNfw2bgaAM8NC2s_28yP2-vX5XFZqNJAzy-bdh4b5TOjcyfq3NDfvGb2--XMzPlT1ImlZ4</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>van Nistelrooij, Anna M.J.</creator><creator>van Steenbergen, Liza N.</creator><creator>Spaander, Manon C.W.</creator><creator>Tilanus, Hugo W.</creator><creator>van Lanschot, J. Jan B.</creator><creator>Lemmens, Valery E.P.P.</creator><creator>Wijnhoven, Bas P.L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Treatment and outcome of young patients with esophageal cancer in the Netherlands</title><author>van Nistelrooij, Anna M.J. ; van Steenbergen, Liza N. ; Spaander, Manon C.W. ; Tilanus, Hugo W. ; van Lanschot, J. Jan B. ; Lemmens, Valery E.P.P. ; Wijnhoven, Bas P.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4263-63a0b14b7c375a2df171d7dcd7230d55ea712159a7a43b9cdbc10aa3c1b56d613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - therapy</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>Esophagectomy - statistics & numerical data</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy - statistics & numerical data</topic><topic>Neoplasm Staging</topic><topic>Netherlands</topic><topic>Palliative Care - statistics & numerical data</topic><topic>Proportional Hazards Models</topic><topic>Registries</topic><topic>Sex Factors</topic><topic>surgical treatment</topic><topic>young patients</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Nistelrooij, Anna M.J.</creatorcontrib><creatorcontrib>van Steenbergen, Liza N.</creatorcontrib><creatorcontrib>Spaander, Manon C.W.</creatorcontrib><creatorcontrib>Tilanus, Hugo W.</creatorcontrib><creatorcontrib>van Lanschot, J. Jan B.</creatorcontrib><creatorcontrib>Lemmens, Valery E.P.P.</creatorcontrib><creatorcontrib>Wijnhoven, Bas P.L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Nistelrooij, Anna M.J.</au><au>van Steenbergen, Liza N.</au><au>Spaander, Manon C.W.</au><au>Tilanus, Hugo W.</au><au>van Lanschot, J. Jan B.</au><au>Lemmens, Valery E.P.P.</au><au>Wijnhoven, Bas P.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment and outcome of young patients with esophageal cancer in the Netherlands</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>109</volume><issue>6</issue><spage>561</spage><epage>566</epage><pages>561-566</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background
Esophageal cancer is increasingly recognized in younger patients. We compared clinicopathological characteristics, treatment, and survival of patients aged ≤50 years with patients aged >50 years diagnosed with esophageal cancer in the Netherlands.
Methods
From the nationwide Netherlands Cancer Registry we identified all patients diagnosed with esophageal cancer between January 2000 and January 2011. Proportions were compared using the χ2 test for categorical variables. Overall and relative survival was calculated.
Results
Eleven percent of the patients (n = 1,466) were aged ≤50 years and adenocarcinoma was the most common tumor type (73.6%). Grade of tumor differentiation was comparable between both age groups (P = 0.460) as well as T‐stage (P = 0.058). Younger patients presented more often with positive lymph nodes (70.1% vs. 66.4%, P = 0.010) and distant metastasis (50.5% vs. 44.7%, P < 0.001) but had surgery more often as compared to older patients: 40.6% versus 37.9%, P = 0.047. There was no significant difference in the 5‐year relative survival between both age groups: 18.1% versus 17.2%, P > 0.05. A subgroup analysis among patients diagnosed with adenocarcinoma revealed similar results.
Conclusions
Young patients with esophageal cancer present with more advanced disease stage and received more often treatment. However, they show comparable relative survival rates with their older counterparts. J. Surg. Oncol. 2014 109:561–566. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24338660</pmid><doi>10.1002/jso.23533</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy Age Factors Aged Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Esophageal cancer Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagectomy - statistics & numerical data Female Health risk assessment Humans Lymphatic Metastasis Male Medical research Middle Aged Neoadjuvant Therapy - statistics & numerical data Neoplasm Staging Netherlands Palliative Care - statistics & numerical data Proportional Hazards Models Registries Sex Factors surgical treatment young patients |
| title | Treatment and outcome of young patients with esophageal cancer in the Netherlands |
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