Simultaneous determination of bosentan and glimepiride in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study

•This is the first report of the simultaneous determination of bosentan and glimepiride levels in human plasma using an UPLC–MS/MS method.•Only 1.5min was needed for an analytical run.•This assay was used to support a clinical study.•A relatively larger number of samples can be analyzed in a short t...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2014-07, Vol.95, p.207-212
Hauptverfasser:	Qiu, Xiangjun, Zhao, Jianlong, Wang, Zhe, Xu, Zhisheng, Xu, Ren-ai
Format:	Artikel
Sprache:	eng
Schlagworte:	Bosentan Chromatography, High Pressure Liquid - methods Drug Stability Glimepiride Human plasma Humans Pharmacokinetic study Spectrometry, Mass, Electrospray Ionization Sulfonamides - blood Sulfonamides - pharmacokinetics Sulfonylurea Compounds - blood Sulfonylurea Compounds - pharmacokinetics Tandem Mass Spectrometry - methods UPLC–MS/MS
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