Determination of chromatographic dissociation constants of some carbapenem group antibiotics and quantification of these compounds in human urine

ABSTRACT The dissociation constant values (sspKa) of some carbapenem group drugs (ertapenem, meropenem, doripenem) in different percentages of methanol–water binary mixtures (18, 20 and 22%, v/v) were determined from the mobile phase pH dependence of their retention factor. Evaluation of these data...

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Veröffentlicht in:	Biomedical chromatography 2014-05, Vol.28 (5), p.660-666
Hauptverfasser:	Çubuk Demiralay, Ebru, Koç, Duygu, Daldal, Y. Doğan, Alsancak, Güleren, Ozkan, Sibel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - urine aqueous pKa values Carbapenem group Carbapenems - pharmacokinetics Carbapenems - urine Chromatography, High Pressure Liquid human urine Humans internal standard Kinetics method optimization nonlinear regression
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