Determination of chromatographic dissociation constants of some carbapenem group antibiotics and quantification of these compounds in human urine
ABSTRACT The dissociation constant values (sspKa) of some carbapenem group drugs (ertapenem, meropenem, doripenem) in different percentages of methanol–water binary mixtures (18, 20 and 22%, v/v) were determined from the mobile phase pH dependence of their retention factor. Evaluation of these data...
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| Veröffentlicht in: | Biomedical chromatography 2014-05, Vol.28 (5), p.660-666 |
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| container_title | Biomedical chromatography |
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| creator | Çubuk Demiralay, Ebru Koç, Duygu Daldal, Y. Doğan Alsancak, Güleren Ozkan, Sibel A. |
| description | ABSTRACT
The dissociation constant values (sspKa) of some carbapenem group drugs (ertapenem, meropenem, doripenem) in different percentages of methanol–water binary mixtures (18, 20 and 22%, v/v) were determined from the mobile phase pH dependence of their retention factor. Evaluation of these data was performed using the NLREG program. From calculated pKa values, the aqueous pKa values of these subtances were calculated by different approaches. Moreover, the correlation established between retention factor and the pH of the water–methanol mobile phase was used to determine the optimum separation conditions. In order to validate the optimized conditions, these drugs were studied in human urine. The chromatographic separation was realized using a Gemini NX C18 column (250 × 4.6 mm i.d., 5 µm particles) and UV detector set at 220 and 295 nm. Copyright © 2013 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/bmc.3085 |
| format | Article |
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The dissociation constant values (sspKa) of some carbapenem group drugs (ertapenem, meropenem, doripenem) in different percentages of methanol–water binary mixtures (18, 20 and 22%, v/v) were determined from the mobile phase pH dependence of their retention factor. Evaluation of these data was performed using the NLREG program. From calculated pKa values, the aqueous pKa values of these subtances were calculated by different approaches. Moreover, the correlation established between retention factor and the pH of the water–methanol mobile phase was used to determine the optimum separation conditions. In order to validate the optimized conditions, these drugs were studied in human urine. The chromatographic separation was realized using a Gemini NX C18 column (250 × 4.6 mm i.d., 5 µm particles) and UV detector set at 220 and 295 nm. Copyright © 2013 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0269-3879</identifier><identifier>EISSN: 1099-0801</identifier><identifier>DOI: 10.1002/bmc.3085</identifier><identifier>PMID: 24343876</identifier><language>eng</language><publisher>England</publisher><subject>Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - urine ; aqueous pKa values ; Carbapenem group ; Carbapenems - pharmacokinetics ; Carbapenems - urine ; Chromatography, High Pressure Liquid ; human urine ; Humans ; internal standard ; Kinetics ; method optimization ; nonlinear regression</subject><ispartof>Biomedical chromatography, 2014-05, Vol.28 (5), p.660-666</ispartof><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3215-52145b977da35dcf8db60c277d7ab0712c98a41bf8e156520fb68658eb87aa093</citedby><cites>FETCH-LOGICAL-c3215-52145b977da35dcf8db60c277d7ab0712c98a41bf8e156520fb68658eb87aa093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbmc.3085$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbmc.3085$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24343876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çubuk Demiralay, Ebru</creatorcontrib><creatorcontrib>Koç, Duygu</creatorcontrib><creatorcontrib>Daldal, Y. Doğan</creatorcontrib><creatorcontrib>Alsancak, Güleren</creatorcontrib><creatorcontrib>Ozkan, Sibel A.</creatorcontrib><title>Determination of chromatographic dissociation constants of some carbapenem group antibiotics and quantification of these compounds in human urine</title><title>Biomedical chromatography</title><addtitle>Biomed Chromatogr</addtitle><description>ABSTRACT
The dissociation constant values (sspKa) of some carbapenem group drugs (ertapenem, meropenem, doripenem) in different percentages of methanol–water binary mixtures (18, 20 and 22%, v/v) were determined from the mobile phase pH dependence of their retention factor. Evaluation of these data was performed using the NLREG program. From calculated pKa values, the aqueous pKa values of these subtances were calculated by different approaches. Moreover, the correlation established between retention factor and the pH of the water–methanol mobile phase was used to determine the optimum separation conditions. In order to validate the optimized conditions, these drugs were studied in human urine. The chromatographic separation was realized using a Gemini NX C18 column (250 × 4.6 mm i.d., 5 µm particles) and UV detector set at 220 and 295 nm. Copyright © 2013 John Wiley & Sons, Ltd.</description><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - urine</subject><subject>aqueous pKa values</subject><subject>Carbapenem group</subject><subject>Carbapenems - pharmacokinetics</subject><subject>Carbapenems - urine</subject><subject>Chromatography, High Pressure Liquid</subject><subject>human urine</subject><subject>Humans</subject><subject>internal standard</subject><subject>Kinetics</subject><subject>method optimization</subject><subject>nonlinear regression</subject><issn>0269-3879</issn><issn>1099-0801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOwzAQRS0EoqUg8QXISzYpthPHzhLKUwKxgXVkO05jVNupnQj1M_hjElrKitW8ztyR5gJwjtEcI0SupFXzFHF6AKYYFUWCOMKHYIpIXiQpZ8UEnMT4gRAqcsKOwYRkaTb08yn4utWdDtY40RnvoK-haoK3ovPLINrGKFiZGL0y27nyLnbCdXEko7caKhGkaLXTFi6D71s4TI00vjMqDnkF1_3YqY3aX-gaHYdFb1vfuypC42DTW-FgH4zTp-CoFquoz3ZxBt7v794Wj8nz68PT4vo5USnBNKEEZ1QWjFUipZWqeSVzpMhQMyERw0QVXGRY1lxjmlOCapnznHItORMCFekMXG512-DXvY5daU1UerUSTvs-lpjinJGUcf6HquBjDLou22CsCJsSo3I0oBwMKEcDBvRip9pLq6s9-PvxAUi2wKdZ6c2_QuXNy-JH8BuDvZK-</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Çubuk Demiralay, Ebru</creator><creator>Koç, Duygu</creator><creator>Daldal, Y. Doğan</creator><creator>Alsancak, Güleren</creator><creator>Ozkan, Sibel A.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Determination of chromatographic dissociation constants of some carbapenem group antibiotics and quantification of these compounds in human urine</title><author>Çubuk Demiralay, Ebru ; Koç, Duygu ; Daldal, Y. Doğan ; Alsancak, Güleren ; Ozkan, Sibel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3215-52145b977da35dcf8db60c277d7ab0712c98a41bf8e156520fb68658eb87aa093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - urine</topic><topic>aqueous pKa values</topic><topic>Carbapenem group</topic><topic>Carbapenems - pharmacokinetics</topic><topic>Carbapenems - urine</topic><topic>Chromatography, High Pressure Liquid</topic><topic>human urine</topic><topic>Humans</topic><topic>internal standard</topic><topic>Kinetics</topic><topic>method optimization</topic><topic>nonlinear regression</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çubuk Demiralay, Ebru</creatorcontrib><creatorcontrib>Koç, Duygu</creatorcontrib><creatorcontrib>Daldal, Y. Doğan</creatorcontrib><creatorcontrib>Alsancak, Güleren</creatorcontrib><creatorcontrib>Ozkan, Sibel A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çubuk Demiralay, Ebru</au><au>Koç, Duygu</au><au>Daldal, Y. Doğan</au><au>Alsancak, Güleren</au><au>Ozkan, Sibel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of chromatographic dissociation constants of some carbapenem group antibiotics and quantification of these compounds in human urine</atitle><jtitle>Biomedical chromatography</jtitle><addtitle>Biomed Chromatogr</addtitle><date>2014-05</date><risdate>2014</risdate><volume>28</volume><issue>5</issue><spage>660</spage><epage>666</epage><pages>660-666</pages><issn>0269-3879</issn><eissn>1099-0801</eissn><abstract>ABSTRACT
The dissociation constant values (sspKa) of some carbapenem group drugs (ertapenem, meropenem, doripenem) in different percentages of methanol–water binary mixtures (18, 20 and 22%, v/v) were determined from the mobile phase pH dependence of their retention factor. Evaluation of these data was performed using the NLREG program. From calculated pKa values, the aqueous pKa values of these subtances were calculated by different approaches. Moreover, the correlation established between retention factor and the pH of the water–methanol mobile phase was used to determine the optimum separation conditions. In order to validate the optimized conditions, these drugs were studied in human urine. The chromatographic separation was realized using a Gemini NX C18 column (250 × 4.6 mm i.d., 5 µm particles) and UV detector set at 220 and 295 nm. Copyright © 2013 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pmid>24343876</pmid><doi>10.1002/bmc.3085</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biomedical chromatography, 2014-05, Vol.28 (5), p.660-666 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - urine aqueous pKa values Carbapenem group Carbapenems - pharmacokinetics Carbapenems - urine Chromatography, High Pressure Liquid human urine Humans internal standard Kinetics method optimization nonlinear regression |
| title | Determination of chromatographic dissociation constants of some carbapenem group antibiotics and quantification of these compounds in human urine |
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