Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6/36 cells

•Serial passage in Vero cells selects for DENV-2 resistance to entry inhibitors 78.•Alteration in antiviral susceptibility is linked to a differential mode of entry 80.•Host cell for DENV-2 growth is relevant for route and inhibition of viral entry 80.•There is a link between response to entry inhib...

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Veröffentlicht in:	Virus research 2014-05, Vol.184, p.39-43
Hauptverfasser:	Acosta, Eliana G., Piccini, Luana E., Talarico, Laura B., Castilla, Viviana, Damonte, Elsa B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Biological Animals Antiviral activity Antiviral Agents - pharmacology Carrageenan Carrageenan - pharmacology Cell Line Cercopithecus aethiops Clathrin-mediated endocytosis Culicidae Dengue virus Dengue Virus - drug effects Dengue Virus - growth & development DNA Mutational Analysis Drug Resistance, Viral Endocytosis - drug effects Entry inhibitor Heparin - pharmacology Molecular Sequence Data RNA, Viral - genetics Sequence Analysis, DNA Serial Passage Sulfated polysaccharide Viral Plaque Assay Virus Internalization - drug effects
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