The function of elastic fibers in the arteries: Beyond elasticity
The main components of elastic fibers, elastin and fibrillin-containing microfibrils play a structural and mechanical role in the arteries and their essential function is to provide elasticity and resilience to the tissues. However, through control of the quiescent contractile phenotype of arterial...
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| Veröffentlicht in: | Pathologie biologie (Paris) 2014-04, Vol.62 (2), p.79-83 |
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| creator | Lannoy, M. Slove, S. Jacob, M.-P. |
| description | The main components of elastic fibers, elastin and fibrillin-containing microfibrils play a structural and mechanical role in the arteries and their essential function is to provide elasticity and resilience to the tissues. However, through control of the quiescent contractile phenotype of arterial smooth muscle cells, elastin also acts as an autocrine factor and, via the binding of ‘latent transforming growth factor (TGF)-β binding protein (LTBP) – latency-associated peptide (LAP) – TGF-β’ complexes, fibrillins regulate the activation and availability of TGF-βs. These recent discoveries are detailed in this review.
Les principales composantes des fibres élastiques, l’élastine et les microfibrilles contenant les fibrillines, jouent un rôle structural et mécanique dans l’aorte et les artères et leur fonction essentielle est de fournir l’élasticité aux tissus. Toutefois, grâce au contrôle du phénotype contractile et quiescent des cellules musculaires lisses artérielles, l’élastine agit également comme un facteur autocrine et, par l’intermédiaire de la liaison des complexes « latent transforming growth factor (TGF)-β binding protein (LTBP) – latency-associated peptide (LAP) – TGF-β », les fibrillines régulent l’activation et la biodisponibilité des TGF-β. Ces découvertes récentes sont détaillées dans cette revue. |
| doi_str_mv | 10.1016/j.patbio.2014.02.011 |
| format | Article |
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Les principales composantes des fibres élastiques, l’élastine et les microfibrilles contenant les fibrillines, jouent un rôle structural et mécanique dans l’aorte et les artères et leur fonction essentielle est de fournir l’élasticité aux tissus. Toutefois, grâce au contrôle du phénotype contractile et quiescent des cellules musculaires lisses artérielles, l’élastine agit également comme un facteur autocrine et, par l’intermédiaire de la liaison des complexes « latent transforming growth factor (TGF)-β binding protein (LTBP) – latency-associated peptide (LAP) – TGF-β », les fibrillines régulent l’activation et la biodisponibilité des TGF-β. Ces découvertes récentes sont détaillées dans cette revue.</description><identifier>ISSN: 0369-8114</identifier><identifier>EISSN: 1768-3114</identifier><identifier>DOI: 10.1016/j.patbio.2014.02.011</identifier><identifier>PMID: 24679588</identifier><language>eng</language><publisher>Paris: Elsevier SAS</publisher><subject>Animals ; Aorte ; Arteries ; Arteries - physiology ; Arteries - ultrastructure ; Artères ; Autocrine Communication ; Biological and medical sciences ; Blood vessels and receptors ; Elastic fibers ; Elastic Tissue - physiology ; Elastic Tissue - ultrastructure ; Elasticity ; Elastin ; Elastin - genetics ; Elastin - physiology ; Fibres élastiques ; Fibrillin ; Fibrilline ; Fibrillins ; Fundamental and applied biological sciences. Psychology ; Glycoproteins - physiology ; Humans ; Mice ; Mice, Knockout ; Microfibrilles ; Microfibrils ; Microfibrils - physiology ; Microfibrils - ultrastructure ; Microfilament Proteins - physiology ; Myocytes, Smooth Muscle - cytology ; Protein Precursors - metabolism ; Protein Processing, Post-Translational ; TGF-β ; TGF-β, Aorta ; Transforming Growth Factor beta - metabolism ; Vascular Resistance - physiology ; Vasoconstriction - physiology ; Vertebrates: cardiovascular system ; Williams Syndrome - genetics ; Williams Syndrome - metabolism ; Williams Syndrome - pathology ; Élastine</subject><ispartof>Pathologie biologie (Paris), 2014-04, Vol.62 (2), p.79-83</ispartof><rights>2014 Elsevier Masson SAS</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-c1d6278f48e23f2b86f3839ab7ff2238fdf43cb5d4887f14570b557aefeb32a53</citedby><cites>FETCH-LOGICAL-c392t-c1d6278f48e23f2b86f3839ab7ff2238fdf43cb5d4887f14570b557aefeb32a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.patbio.2014.02.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28348741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24679588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lannoy, M.</creatorcontrib><creatorcontrib>Slove, S.</creatorcontrib><creatorcontrib>Jacob, M.-P.</creatorcontrib><title>The function of elastic fibers in the arteries: Beyond elasticity</title><title>Pathologie biologie (Paris)</title><addtitle>Pathol Biol (Paris)</addtitle><description>The main components of elastic fibers, elastin and fibrillin-containing microfibrils play a structural and mechanical role in the arteries and their essential function is to provide elasticity and resilience to the tissues. However, through control of the quiescent contractile phenotype of arterial smooth muscle cells, elastin also acts as an autocrine factor and, via the binding of ‘latent transforming growth factor (TGF)-β binding protein (LTBP) – latency-associated peptide (LAP) – TGF-β’ complexes, fibrillins regulate the activation and availability of TGF-βs. These recent discoveries are detailed in this review.
Les principales composantes des fibres élastiques, l’élastine et les microfibrilles contenant les fibrillines, jouent un rôle structural et mécanique dans l’aorte et les artères et leur fonction essentielle est de fournir l’élasticité aux tissus. Toutefois, grâce au contrôle du phénotype contractile et quiescent des cellules musculaires lisses artérielles, l’élastine agit également comme un facteur autocrine et, par l’intermédiaire de la liaison des complexes « latent transforming growth factor (TGF)-β binding protein (LTBP) – latency-associated peptide (LAP) – TGF-β », les fibrillines régulent l’activation et la biodisponibilité des TGF-β. Ces découvertes récentes sont détaillées dans cette revue.</description><subject>Animals</subject><subject>Aorte</subject><subject>Arteries</subject><subject>Arteries - physiology</subject><subject>Arteries - ultrastructure</subject><subject>Artères</subject><subject>Autocrine Communication</subject><subject>Biological and medical sciences</subject><subject>Blood vessels and receptors</subject><subject>Elastic fibers</subject><subject>Elastic Tissue - physiology</subject><subject>Elastic Tissue - ultrastructure</subject><subject>Elasticity</subject><subject>Elastin</subject><subject>Elastin - genetics</subject><subject>Elastin - physiology</subject><subject>Fibres élastiques</subject><subject>Fibrillin</subject><subject>Fibrilline</subject><subject>Fibrillins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoproteins - physiology</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Microfibrilles</subject><subject>Microfibrils</subject><subject>Microfibrils - physiology</subject><subject>Microfibrils - ultrastructure</subject><subject>Microfilament Proteins - physiology</subject><subject>Myocytes, Smooth Muscle - cytology</subject><subject>Protein Precursors - metabolism</subject><subject>Protein Processing, Post-Translational</subject><subject>TGF-β</subject><subject>TGF-β, Aorta</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Vascular Resistance - physiology</subject><subject>Vasoconstriction - physiology</subject><subject>Vertebrates: cardiovascular system</subject><subject>Williams Syndrome - genetics</subject><subject>Williams Syndrome - metabolism</subject><subject>Williams Syndrome - pathology</subject><subject>Élastine</subject><issn>0369-8114</issn><issn>1768-3114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A5FeBC-tmSRtsh4EXfwCwYueQ5pOMEu3XZOssP_eLt3Vm6eZw_O-MzyEnAMtgEJ1PS-WJtW-LxgFUVBWUIA9MgFZqZwDiH0yobya5mrYj8hxjHNKQYKAQ3LERCWnpVITcvf-iZlbdTb5vst6l2FrYvI2c77GEDPfZWkgTEgYPMab7B7XfdfsMJ_Wp-TAmTbi2XaekI_Hh_fZc_769vQyu3vNLZ-ylFtoKiaVEwoZd6xWleOKT00tnWOMK9c4wW1dNkIp6UCUktZlKQ06rDkzJT8hV2PvMvRfK4xJL3y02Lamw34VNZRQScapEgMqRtSGPsaATi-DX5iw1kD1Rp6e61Ge3sjTlOlB3hC72F5Y1QtsfkM7WwNwuQVMtKZ1wXTWxz9OcaGk2BTdjhwOPr49Bh2tx85i4wPapJve___JDyrxjlI</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Lannoy, M.</creator><creator>Slove, S.</creator><creator>Jacob, M.-P.</creator><general>Elsevier SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>The function of elastic fibers in the arteries: Beyond elasticity</title><author>Lannoy, M. ; Slove, S. ; Jacob, M.-P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-c1d6278f48e23f2b86f3839ab7ff2238fdf43cb5d4887f14570b557aefeb32a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Aorte</topic><topic>Arteries</topic><topic>Arteries - physiology</topic><topic>Arteries - ultrastructure</topic><topic>Artères</topic><topic>Autocrine Communication</topic><topic>Biological and medical sciences</topic><topic>Blood vessels and receptors</topic><topic>Elastic fibers</topic><topic>Elastic Tissue - physiology</topic><topic>Elastic Tissue - ultrastructure</topic><topic>Elasticity</topic><topic>Elastin</topic><topic>Elastin - genetics</topic><topic>Elastin - physiology</topic><topic>Fibres élastiques</topic><topic>Fibrillin</topic><topic>Fibrilline</topic><topic>Fibrillins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycoproteins - physiology</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Microfibrilles</topic><topic>Microfibrils</topic><topic>Microfibrils - physiology</topic><topic>Microfibrils - ultrastructure</topic><topic>Microfilament Proteins - physiology</topic><topic>Myocytes, Smooth Muscle - cytology</topic><topic>Protein Precursors - metabolism</topic><topic>Protein Processing, Post-Translational</topic><topic>TGF-β</topic><topic>TGF-β, Aorta</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Vascular Resistance - physiology</topic><topic>Vasoconstriction - physiology</topic><topic>Vertebrates: cardiovascular system</topic><topic>Williams Syndrome - genetics</topic><topic>Williams Syndrome - metabolism</topic><topic>Williams Syndrome - pathology</topic><topic>Élastine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lannoy, M.</creatorcontrib><creatorcontrib>Slove, S.</creatorcontrib><creatorcontrib>Jacob, M.-P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathologie biologie (Paris)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lannoy, M.</au><au>Slove, S.</au><au>Jacob, M.-P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The function of elastic fibers in the arteries: Beyond elasticity</atitle><jtitle>Pathologie biologie (Paris)</jtitle><addtitle>Pathol Biol (Paris)</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>62</volume><issue>2</issue><spage>79</spage><epage>83</epage><pages>79-83</pages><issn>0369-8114</issn><eissn>1768-3114</eissn><abstract>The main components of elastic fibers, elastin and fibrillin-containing microfibrils play a structural and mechanical role in the arteries and their essential function is to provide elasticity and resilience to the tissues. However, through control of the quiescent contractile phenotype of arterial smooth muscle cells, elastin also acts as an autocrine factor and, via the binding of ‘latent transforming growth factor (TGF)-β binding protein (LTBP) – latency-associated peptide (LAP) – TGF-β’ complexes, fibrillins regulate the activation and availability of TGF-βs. These recent discoveries are detailed in this review.
Les principales composantes des fibres élastiques, l’élastine et les microfibrilles contenant les fibrillines, jouent un rôle structural et mécanique dans l’aorte et les artères et leur fonction essentielle est de fournir l’élasticité aux tissus. Toutefois, grâce au contrôle du phénotype contractile et quiescent des cellules musculaires lisses artérielles, l’élastine agit également comme un facteur autocrine et, par l’intermédiaire de la liaison des complexes « latent transforming growth factor (TGF)-β binding protein (LTBP) – latency-associated peptide (LAP) – TGF-β », les fibrillines régulent l’activation et la biodisponibilité des TGF-β. Ces découvertes récentes sont détaillées dans cette revue.</abstract><cop>Paris</cop><pub>Elsevier SAS</pub><pmid>24679588</pmid><doi>10.1016/j.patbio.2014.02.011</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pathologie biologie (Paris), 2014-04, Vol.62 (2), p.79-83 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Aorte Arteries Arteries - physiology Arteries - ultrastructure Artères Autocrine Communication Biological and medical sciences Blood vessels and receptors Elastic fibers Elastic Tissue - physiology Elastic Tissue - ultrastructure Elasticity Elastin Elastin - genetics Elastin - physiology Fibres élastiques Fibrillin Fibrilline Fibrillins Fundamental and applied biological sciences. Psychology Glycoproteins - physiology Humans Mice Mice, Knockout Microfibrilles Microfibrils Microfibrils - physiology Microfibrils - ultrastructure Microfilament Proteins - physiology Myocytes, Smooth Muscle - cytology Protein Precursors - metabolism Protein Processing, Post-Translational TGF-β TGF-β, Aorta Transforming Growth Factor beta - metabolism Vascular Resistance - physiology Vasoconstriction - physiology Vertebrates: cardiovascular system Williams Syndrome - genetics Williams Syndrome - metabolism Williams Syndrome - pathology Élastine |
| title | The function of elastic fibers in the arteries: Beyond elasticity |
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