Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method

Abstract The potential antiviral resistance mutations within hepatitis B virus (HBV) reverse transcriptase (RT) region for nucleos(t)ide analogues (NA) are not well known. Especially, the effect of pre-existing antiviral drug resistance mutations in untreated patients in comparison to the resistance...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2014-05, Vol.79 (1), p.25-30
Hauptverfasser:	Ciftci, Sevgi, Keskin, Fahriye, Cakiris, Aris, Akyuz, Filiz, Pinarbasi, Binnur, Abaci, Neslihan, Dincer, Erdinc, Badur, Selim, Kaymakoglu, Sabahattin, Ustek, Duran
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antiviral Agents - therapeutic use Drug Resistance, Viral - genetics Female Genes, Viral HBV-RT domain Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B, Chronic - virology High-Throughput Nucleotide Sequencing - methods Humans Infectious Disease Internal Medicine Male Molecular Typing - methods Mutation Potential mutations Sequence Analysis, DNA - methods UDPS Untreated chronic patients Young Adult
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