Spinal ERK2 activation through δ2-opioid receptors contributes to nociceptive behavior induced by intrathecal injection of leucine-enkephalin

•Nociceptive behavior was not observed in mice treated with i.t. Leu-ENK alone.•Leu-ENK co-injected with peptidase inhibitors evoked nociceptive behaviors.•Leu-ENK co-injected with peptidase inhibitors evoked activation of spinal ERK2.•The nociceptive behavioral response was evoked through spinal δ2...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2014-04, Vol.54, p.131-139
Hauptverfasser:	Komatsu, Takaaki, Katsuyama, Soh, Mizoguchi, Hirokazu, Sakurada, Chikai, Tsuzuki, Minoru, Sakurada, Shinobu, Sakurada, Tsukasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - pharmacology Behavior, Animal - drug effects Butadienes - pharmacology Dorsal spinal cord Enkephalin, Leucine - administration & dosage Enkephalin, Leucine - pharmacology Enzyme Activation - drug effects Extracellular signal-regulated kinase (ERK) Glutamate Glycopeptides - pharmacology Injections, Spinal Leucine - analogs & derivatives Leucine - pharmacology Leucine-enkephalin Male Mice Mice, Inbred Strains Mitogen-Activated Protein Kinase 1 - metabolism Naltrexone - analogs & derivatives Naltrexone - pharmacology NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide (NO) Nitric Oxide Synthase - antagonists & inhibitors Nitriles - pharmacology Nociception - drug effects Nociceptive behavior Protease Inhibitors - pharmacology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, Opioid, delta - antagonists & inhibitors Receptors, Opioid, delta - metabolism Spinal Cord - drug effects Spinal Cord - metabolism δ2-Opioid receptor
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