Epigenetic and expression analysis of TRAIL-R2 and BCL2: on the TRAIL to knowledge of apoptosis in ovarian tumors

Objective This study assesses TRAIL - R2 ( TNF-related apoptosis-inducing ligand receptor 2) and BCL2 (B cell CLL/lymphoma 2) expression as well as CpG island methylation within the TRAIL - R2 promoter in ovarian serous tumors and primary and metastatic serous EOC (epithelial ovarian cancer). Method...

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Veröffentlicht in:	Archives of gynecology and obstetrics 2014-05, Vol.289 (5), p.1061-1069
Hauptverfasser:	da Conceição Braga, Letícia, Silva, Luciana Maria, Piedade, Josiane Barbosa, Traiman, Paulo, da Silva Filho, Agnaldo Lopes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis Apoptosis Regulatory Proteins - genetics Carcinoma, Ovarian Epithelial Cell Line, Tumor Cystadenoma, Serous - genetics Deoxyribonucleic acid DNA DNA Methylation Endocrinology Epigenesis, Genetic Female Gene Expression Gynecologic Oncology Gynecology Human Genetics Humans Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Staging Neoplasms, Glandular and Epithelial - genetics Obstetrics/Perinatology/Midwifery Ovarian cancer Ovarian Neoplasms - genetics Polymerase Chain Reaction Promoter Regions, Genetic Prospective Studies Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Statistics, Nonparametric Tumors
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