Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities

A series of novel amino acid and dipeptide derivatives of neocryptolepine were synthesized and tested for their antimicrobial, antifungal and antiproliferative activity in vitro against cancer cell lines (KB, A549, MCF-7, LoVo) and normal mice fibroblast cells (BALB/3T3). Biological evaluation revea...

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Veröffentlicht in:	European journal of medicinal chemistry 2014-05, Vol.78, p.304-313
Hauptverfasser:	Sidoryk, Katarzyna, Jaromin, Anna, Edward, Jessica A, Świtalska, Marta, Stefańska, Joanna, Cmoch, Piotr, Zagrodzka, Joanna, Szczepek, Wojciech, Peczyńska-Czoch, Wanda, Wietrzyk, Joanna, Kozubek, Arkadiusz, Zarnowski, Robert, Andes, David R, Kaczmarek, Łukasz
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Alkaloids - chemistry Alkaloids - pharmacology Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology BALB 3T3 Cells Biofilms - drug effects Candida albicans - drug effects Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Fibroblasts - drug effects Humans MCF-7 Cells Mice Mice, Inbred BALB C Microbial Sensitivity Tests Molecular Structure Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Structure-Activity Relationship
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