Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status
This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (L...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2014-05, Vol.37 (4), p.455-463 |
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| container_title | Journal of thrombosis and thrombolysis |
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| creator | Zhang, Xuguang McGeoch, Susan C. Johnstone, Alexandra M. Holtrop, Grietje Sneddon, Alan A. MacRury, Sandra M. Megson, Ian L. Pearson, Donald W. M. Abraham, Prakash De Roos, Baukje Lobley, Gerald E. O’Kennedy, Niamh |
| description | This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (
P
= 0.003), and PMP that were fibrinogen-positive (
P
= 0.04), tissue factor-positive (
P
|
| doi_str_mv | 10.1007/s11239-013-1000-2 |
| format | Article |
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P
= 0.003), and PMP that were fibrinogen-positive (
P
= 0.04), tissue factor-positive (
P
< 0.001), P-selectin-positive (
P
= 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.</description><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1007/s11239-013-1000-2</identifier><identifier>PMID: 24097206</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Atherosclerosis - blood ; Atherosclerosis - etiology ; Biomarkers - blood ; Blood Platelets ; Cardiology ; Cell-Derived Microparticles - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetic Angiopathies - blood ; Female ; Hematology ; Humans ; Leukocyte Count ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity - blood ; Platelet Activation ; Risk Factors</subject><ispartof>Journal of thrombosis and thrombolysis, 2014-05, Vol.37 (4), p.455-463</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-d46aa55c811bb0667b531b1d71075ce43a85a844bb75a439b314c488c25b8d503</citedby><cites>FETCH-LOGICAL-c372t-d46aa55c811bb0667b531b1d71075ce43a85a844bb75a439b314c488c25b8d503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11239-013-1000-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11239-013-1000-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24097206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xuguang</creatorcontrib><creatorcontrib>McGeoch, Susan C.</creatorcontrib><creatorcontrib>Johnstone, Alexandra M.</creatorcontrib><creatorcontrib>Holtrop, Grietje</creatorcontrib><creatorcontrib>Sneddon, Alan A.</creatorcontrib><creatorcontrib>MacRury, Sandra M.</creatorcontrib><creatorcontrib>Megson, Ian L.</creatorcontrib><creatorcontrib>Pearson, Donald W. M.</creatorcontrib><creatorcontrib>Abraham, Prakash</creatorcontrib><creatorcontrib>De Roos, Baukje</creatorcontrib><creatorcontrib>Lobley, Gerald E.</creatorcontrib><creatorcontrib>O’Kennedy, Niamh</creatorcontrib><title>Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><addtitle>J Thromb Thrombolysis</addtitle><description>This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (
P
= 0.003), and PMP that were fibrinogen-positive (
P
= 0.04), tissue factor-positive (
P
< 0.001), P-selectin-positive (
P
= 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.</description><subject>Adult</subject><subject>Aged</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - etiology</subject><subject>Biomarkers - blood</subject><subject>Blood Platelets</subject><subject>Cardiology</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetic Angiopathies - blood</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Platelet Activation</subject><subject>Risk Factors</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc2KFTEQhYMozp3RB3AjATcubM1vp7OUQR1hQBcK7pokXa25dCdtfhzvy_is5npHEcFNkqK-c6rIQegRJc8pIepFppRx3RHKu1aTjt1BOyoV75Rgn-6iHdFMd5ITeYbOc943RGvC7qMzJohWjPQ79OP9YgosULoJkv8GE169S3EzqXi3AHaxhoJNmHCuaTYO8BoXcLW14PuWIGcfA578PEPCFsoNQGio3YMrGd_48uWX-PiIteBy2ACzxpvGQn6GfZhgg3aEshxwnHG0kH054FxMqfkBujebJcPD2_sCfXz96sPlVXf97s3by5fXneOKtd1Fb4yUbqDUWtL3ykpOLZ0UJUo6ENwM0gxCWKukEVxbToUTw-CYtMMkCb9AT0--W4pfK-Qyrj47WBYTINY8Ukl7rgfeDw198g-6jzWFtt2RkkLqnqhG0RPVPjPnBPO4Jb-adBgpGY_hjafwxhbesSYja5rHt87VrjD9UfxOqwHsBOTWCp8h_TX6v64_AclApz0</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Zhang, Xuguang</creator><creator>McGeoch, Susan C.</creator><creator>Johnstone, Alexandra M.</creator><creator>Holtrop, Grietje</creator><creator>Sneddon, Alan A.</creator><creator>MacRury, Sandra M.</creator><creator>Megson, Ian L.</creator><creator>Pearson, Donald W. M.</creator><creator>Abraham, Prakash</creator><creator>De Roos, Baukje</creator><creator>Lobley, Gerald E.</creator><creator>O’Kennedy, Niamh</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status</title><author>Zhang, Xuguang ; McGeoch, Susan C. ; Johnstone, Alexandra M. ; Holtrop, Grietje ; Sneddon, Alan A. ; MacRury, Sandra M. ; Megson, Ian L. ; Pearson, Donald W. M. ; Abraham, Prakash ; De Roos, Baukje ; Lobley, Gerald E. ; O’Kennedy, Niamh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-d46aa55c811bb0667b531b1d71075ce43a85a844bb75a439b314c488c25b8d503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - etiology</topic><topic>Biomarkers - blood</topic><topic>Blood Platelets</topic><topic>Cardiology</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetic Angiopathies - blood</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Platelet Activation</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xuguang</creatorcontrib><creatorcontrib>McGeoch, Susan C.</creatorcontrib><creatorcontrib>Johnstone, Alexandra M.</creatorcontrib><creatorcontrib>Holtrop, Grietje</creatorcontrib><creatorcontrib>Sneddon, Alan A.</creatorcontrib><creatorcontrib>MacRury, Sandra M.</creatorcontrib><creatorcontrib>Megson, Ian L.</creatorcontrib><creatorcontrib>Pearson, Donald W. M.</creatorcontrib><creatorcontrib>Abraham, Prakash</creatorcontrib><creatorcontrib>De Roos, Baukje</creatorcontrib><creatorcontrib>Lobley, Gerald E.</creatorcontrib><creatorcontrib>O’Kennedy, Niamh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xuguang</au><au>McGeoch, Susan C.</au><au>Johnstone, Alexandra M.</au><au>Holtrop, Grietje</au><au>Sneddon, Alan A.</au><au>MacRury, Sandra M.</au><au>Megson, Ian L.</au><au>Pearson, Donald W. M.</au><au>Abraham, Prakash</au><au>De Roos, Baukje</au><au>Lobley, Gerald E.</au><au>O’Kennedy, Niamh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>37</volume><issue>4</issue><spage>455</spage><epage>463</epage><pages>455-463</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (
P
= 0.003), and PMP that were fibrinogen-positive (
P
= 0.04), tissue factor-positive (
P
< 0.001), P-selectin-positive (
P
= 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24097206</pmid><doi>10.1007/s11239-013-1000-2</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of thrombosis and thrombolysis, 2014-05, Vol.37 (4), p.455-463 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Atherosclerosis - blood Atherosclerosis - etiology Biomarkers - blood Blood Platelets Cardiology Cell-Derived Microparticles - metabolism Diabetes Mellitus, Type 2 - blood Diabetic Angiopathies - blood Female Hematology Humans Leukocyte Count Male Medicine Medicine & Public Health Middle Aged Obesity - blood Platelet Activation Risk Factors |
| title | Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status |
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