A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties

This report describes the design, generation and testing of Ylanthia, a fully synthetic human Fab antibody library with 1.3E+11 clones. Ylanthia comprises 36 fixed immunoglobulin (Ig) variable heavy (VH)/variable light (VL) chain pairs, which cover a broad range of canonical complementarity-determin...

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Veröffentlicht in:	mAbs 2013-05, Vol.5 (3), p.445-470
Hauptverfasser:	Tiller, Thomas, Schuster, Ingrid, Deppe, Dorothée, Siegers, Katja, Strohner, Ralf, Herrmann, Tanja, Berenguer, Marion, Poujol, Dominique, Stehle, Jennifer, Stark, Yvonne, Heßling, Martin, Daubert, Daniela, Felderer, Karin, Kaden, Stefan, Kölln, Johanna, Enzelberger, Markus, Urlinger, Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - genetics Antibodies, Monoclonal - therapeutic use Antibody Affinity antibody engineering CDR-H3 design Cells, Cultured Complementarity Determining Regions - genetics Dimerization Drug Design Gene Expression Gene Library human antibody library Humans Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunoglobulin Heavy Chains - genetics Immunoglobulin Light Chains - genetics Immunotherapy phage display Protein Engineering Protein Stability Slonomics VH/VL pairing Ylanthia
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