Soluble interleukin-2 receptor level on day 7 as a predictor of graft-versus-host disease after HLA-haploidentical stem cell transplantation using reduced-intensity conditioning
In the present study, we analyzed the kinetics of serum soluble interleukin-2 receptor (sIL-2R) using data from 77 patients undergoing HLA-haploidentical transplantation using reduced-intensity conditioning (RIC), who were at an advanced stage or at high risk for relapse, to clarify the usefulness o...
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| Veröffentlicht in: | International journal of hematology 2014-04, Vol.99 (4), p.463-470 |
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| creator | Kaida, Katsuji Ikegame, Kazuhiro Ikemoto, Junko Murata, Rie Irie, Reiko Yoshihara, Satoshi Ishii, Shinichi Okada, Masaya Inoue, Takayuki Tamaki, Hiroya Soma, Toshihiro Fujimori, Yoshihiro Kai, Shunro Ogawa, Hiroyasu |
| description | In the present study, we analyzed the kinetics of serum soluble interleukin-2 receptor (sIL-2R) using data from 77 patients undergoing HLA-haploidentical transplantation using reduced-intensity conditioning (RIC), who were at an advanced stage or at high risk for relapse, to clarify the usefulness of sIL-2R as a biomarker of acute graft-versus-host disease (GVHD). Anti-T-lymphocyte globulin and methylprednisolone were used as GVHD prophylaxis. While the median sIL-2R in 38 patients not developing GVHD was suppressed at levels |
| doi_str_mv | 10.1007/s12185-014-1542-x |
| format | Article |
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p
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p
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Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaida, Katsuji</au><au>Ikegame, Kazuhiro</au><au>Ikemoto, Junko</au><au>Murata, Rie</au><au>Irie, Reiko</au><au>Yoshihara, Satoshi</au><au>Ishii, Shinichi</au><au>Okada, Masaya</au><au>Inoue, Takayuki</au><au>Tamaki, Hiroya</au><au>Soma, Toshihiro</au><au>Fujimori, Yoshihiro</au><au>Kai, Shunro</au><au>Ogawa, Hiroyasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble interleukin-2 receptor level on day 7 as a predictor of graft-versus-host disease after HLA-haploidentical stem cell transplantation using reduced-intensity conditioning</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>99</volume><issue>4</issue><spage>463</spage><epage>470</epage><pages>463-470</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>In the present study, we analyzed the kinetics of serum soluble interleukin-2 receptor (sIL-2R) using data from 77 patients undergoing HLA-haploidentical transplantation using reduced-intensity conditioning (RIC), who were at an advanced stage or at high risk for relapse, to clarify the usefulness of sIL-2R as a biomarker of acute graft-versus-host disease (GVHD). Anti-T-lymphocyte globulin and methylprednisolone were used as GVHD prophylaxis. While the median sIL-2R in 38 patients not developing GVHD was suppressed at levels <740 U/ml, sIL-2R in 25 patients developing severe GVHD peaked on day 11 (1,663 U/ml), and thereafter decreased to <1,000 U/ml after day 30. The occurrence of GVHD was not limited to times of high sIL-2R level, but occurred at any time point on the sIL-2R curve. Most patients developing GVHD, however, experienced a higher sIL-2R level early in their transplant course. The combination of RIC and glucocorticoids sufficiently suppressed sIL-2R levels after HLA-haploidentical transplantation. In a multivariate analysis to identify factors associated with GVHD, day 7 sIL-2R >810 U/ml was the only factor significantly associated with the occurrence of severe GVHD (
p
= 0.0101).</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24599414</pmid><doi>10.1007/s12185-014-1542-x</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of hematology, 2014-04, Vol.99 (4), p.463-470 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Female Graft vs Host Disease - blood Graft vs Host Disease - diagnosis Graft vs Host Disease - etiology Haplotypes Hematologic and hematopoietic diseases Hematology Hematopoietic Stem Cell Transplantation - adverse effects HLA Antigens - genetics HLA Antigens - immunology Humans Male Medical sciences Medicine Medicine & Public Health Middle Aged Oncology Original Article Prognosis Receptors, Interleukin-2 - blood Retrospective Studies ROC Curve Time Factors Transplantation Conditioning - adverse effects Young Adult |
| title | Soluble interleukin-2 receptor level on day 7 as a predictor of graft-versus-host disease after HLA-haploidentical stem cell transplantation using reduced-intensity conditioning |
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