PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

Under resting conditions, Pink1 knockout cells and cells derived from patients with PINK1 mutations display a loss of mitochondrial complex I reductive activity, causing a decrease in the mitochondrial membrane potential. Analyzing the phosphoproteome of complex I in liver and brain from Pink1–/– mi...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2014-04, Vol.344 (6180), p.203-207
Hauptverfasser:	Morais, Vanessa A., Haddad, Dominik, Craessaerts, Katleen, De Bock, Pieter-Jan, Swerts, Jef, Vilain, Sven, Aerts, Liesbeth, Overbergh, Lut, Grünewald, Anne, Seibler, Philip, Klein, Christine, Gevaert, Kris, Verstreken, Patrik, De Strooper, Bart
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Brain - enzymology Cell lines Drosophila Drosophila Proteins - metabolism Electron transfer Electron Transport Complex I - metabolism Fibroblasts Fluorescence Gene expression Genetic mutation Humans Liver - enzymology Membrane Potential, Mitochondrial - genetics Mice Mice, Knockout Mitochondria Mitochondrial membranes Molecular Sequence Data Mutation NADH Dehydrogenase - metabolism Parkinson Disease - enzymology Parkinson Disease - genetics Pathogenesis Patients Phosphorylation Phosphorylation - genetics Protein Kinases - genetics Proteome Quantification Serine - chemistry Serine - metabolism Stem cells
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