A Developmental Switch of Axon Targeting in the Continuously Regenerating Mouse Olfactory System

The mammalian olfactory system has the natural capacity to regenerate throughout the animal's life span. Despite constant neurogenesis, olfactory sensory neurons project to precise, stereotypical positions in the brain. Here, we identify a critical period of olfactory sensory axon targeting dur...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2014-04, Vol.344 (6180), p.194-197
Hauptverfasser:	Ma, Limei, Wu, Yunming, Qiu, Qiang, Scheerer, Hayley, Moran, Andrea, Yu, C. Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Animals Axons Axons - physiology Chemosensory perception Critical periods Developmental Programs Doxorubicin - pharmacology Gene expression Gene Expression Regulation, Developmental Mice Mice, Mutant Strains Nerve Regeneration - genetics Nerve Regeneration - physiology Neurons Neuroscience Nose Olfactory bulb Olfactory Bulb - growth & development Olfactory Bulb - physiology Olfactory Receptor Neurons - growth & development Potassium Channels, Inwardly Rectifying - genetics Receptors Receptors, Odorant - genetics Receptors, Odorant - physiology Rodents Sensory neurons Smell Trans-Activators - antagonists & inhibitors
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