Transforming growth factor beta-1 in acute myocardial infarction in rats

TGF- beta 1 has been examined in the heart during myocardial infarction caused by ligation of the left coronary artery. Infarcted and uninfarcted myocardium have been compared by immunohistochemical staining of TGF- beta 1 and by Northern blot analysis of mRNA. Normal ventricular myocytes are strong...

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Veröffentlicht in:Growth factors (Chur, Switzerland) Switzerland), 1989-01, Vol.1 (1), p.91-99
Hauptverfasser: Thompson, N L, Bazoberry, F, Speir, E H, Casscells, W, Ferrans, V J, Flanders, K C, Kondaiah, P, Geiser, A G, Sporn, M B
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container_issue 1
container_start_page 91
container_title Growth factors (Chur, Switzerland)
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creator Thompson, N L
Bazoberry, F
Speir, E H
Casscells, W
Ferrans, V J
Flanders, K C
Kondaiah, P
Geiser, A G
Sporn, M B
description TGF- beta 1 has been examined in the heart during myocardial infarction caused by ligation of the left coronary artery. Infarcted and uninfarcted myocardium have been compared by immunohistochemical staining of TGF- beta 1 and by Northern blot analysis of mRNA. Normal ventricular myocytes are strongly stained by an antibody to TGF- beta 1. Progressive loss of staining of these myocytes begins within 1 hr after coronary ligation. However, by 24-48 hr after ligation, intense staining of myocytes at the margin of infarcted areas is seen. Northern blots of infarcted myocardium 48 hr after ligation show a 3- to 4-fold increase in the principal 2.4 kb TGF- beta 1 mRNA; there is also a marked increase in a minor 1.9 kb transcript. In the same tissue samples, there is a 2-fold decrease in the mRNA for the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase. The results indicate a significant role for TGF- beta in the response of the heart to injury.
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title Transforming growth factor beta-1 in acute myocardial infarction in rats
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