Monocytes, but not T cells, respond to insulin with Akt(S473) phosphorylation independent of the donor glucometabolic state

Background Obesity is associated with insulin resistance and chronic low‐grade inflammation. Insulin has been described to have anti‐inflammatory effects in immune cells. Therefore, insulin resistance in immune cells can be expected to have important consequences for immune function. Here, we invest...

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Veröffentlicht in:	Diabetes/metabolism research and reviews 2014-05, Vol.30 (4), p.323-332
Hauptverfasser:	Thewissen, M. M., van de Gaar, J., den Boer, A. Th, Munsters, M. J., Blaak, E. E., Duijvestijn, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - metabolism Female glucometabolic state Glucose Intolerance - immunology Glucose Intolerance - metabolism Humans Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology immune cells Insulin - metabolism Insulin - pharmacology Insulin Resistance Male Middle Aged monocytes Monocytes - drug effects Monocytes - immunology Monocytes - metabolism phosflow Phosphorylation - drug effects Prediabetic State - immunology Prediabetic State - metabolism Protein Processing, Post-Translational - drug effects Proto-Oncogene Proteins c-akt - metabolism Serine - chemistry Signal Transduction - drug effects Up-Regulation - drug effects
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