Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis
Highlights • Ninety days of subchronic exposure to samarium nitrate for mouse is performed for male reproductive toxicity evaluation. • Lesions in testis including disorganized seminiferous tubule, decreased spermatogenic cells, and so on are observed. • The lesions inside the cells involve mitochon...
Gespeichert in:
| Veröffentlicht in: | Environmental toxicology and pharmacology 2014-03, Vol.37 (2), p.505-512 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 512 |
|---|---|
| container_issue | 2 |
| container_start_page | 505 |
| container_title | Environmental toxicology and pharmacology |
| container_volume | 37 |
| creator | Zhang, De-Yong Shen, Xiu-Ying Ruan, Qin Xu, Xiao-Lu Yang, San-Ping Lu, Yin Xu, Hui-Ying Hao, Fei-Lin |
| description | Highlights • Ninety days of subchronic exposure to samarium nitrate for mouse is performed for male reproductive toxicity evaluation. • Lesions in testis including disorganized seminiferous tubule, decreased spermatogenic cells, and so on are observed. • The lesions inside the cells involve mitochondria swelling, mitochondria vacuolization, fuzzy nuclear membrane, and so on. • Increased spermatogenic cell apoptosis is confirmed with TUNEL method, as well as changed expression level of Bax and Bcl-2 gene. |
| doi_str_mv | 10.1016/j.etap.2014.01.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1514436682</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1382668914000088</els_id><sourcerecordid>1514436682</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-b31ac120076f2233269daf7343e7469b9767ed08d47a9d288707400becb360443</originalsourceid><addsrcrecordid>eNp9kc1u1TAQha0K1JbCC7BAXrJJ8N-NEwkhoaqllSqxANaW40x6fUni4LGr9u1xdAsLFqw8i3OO53xDyFvOas548-FQQ7JrLRhXNeM1Y_qEnPNWi0ozrV-UWbaiapq2OyOvEA-M8Z2U7Sk5E2rXlFmdE7waR3AJaRgp5t7tY1i8o2hnG32eKTyuAXMEGhaa9kD3HlNYbdqHKdx7ZyeKKWaXNoldBmrXsKaAHmmE-zzZ5IvRL3QOGYEmwOTxNXk52gnhzfN7QX5cX32_vKnuvn65vfx8Vzmldap6ya3jotRqRiGkFE032FFLJUGrpus73WgYWDsobbtBtG1prRjrwfWyYUrJC_L-mLvG8CuXr83s0cE02QXKOobveFEVPqJIxVHqYkCMMJo1-oLgyXBmNtjmYDbYZoNtGDdlq2J695yf-xmGv5Y_dIvg41EApeWDh2jQeVgcDD4W6GYI_v_5n_6xu8kvG_Sf8AR4CDkuhZ_hBoVh5tt27u3avFBgrG3lb9WApuM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1514436682</pqid></control><display><type>article</type><title>Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Zhang, De-Yong ; Shen, Xiu-Ying ; Ruan, Qin ; Xu, Xiao-Lu ; Yang, San-Ping ; Lu, Yin ; Xu, Hui-Ying ; Hao, Fei-Lin</creator><creatorcontrib>Zhang, De-Yong ; Shen, Xiu-Ying ; Ruan, Qin ; Xu, Xiao-Lu ; Yang, San-Ping ; Lu, Yin ; Xu, Hui-Ying ; Hao, Fei-Lin</creatorcontrib><description>Highlights • Ninety days of subchronic exposure to samarium nitrate for mouse is performed for male reproductive toxicity evaluation. • Lesions in testis including disorganized seminiferous tubule, decreased spermatogenic cells, and so on are observed. • The lesions inside the cells involve mitochondria swelling, mitochondria vacuolization, fuzzy nuclear membrane, and so on. • Increased spermatogenic cell apoptosis is confirmed with TUNEL method, as well as changed expression level of Bax and Bcl-2 gene.</description><identifier>ISSN: 1382-6689</identifier><identifier>EISSN: 1872-7077</identifier><identifier>DOI: 10.1016/j.etap.2014.01.007</identifier><identifier>PMID: 24561534</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Apoptosis ; Apoptosis - drug effects ; Bcl-2 ; bcl-2-Associated X Protein - genetics ; Emergency ; Luteinizing Hormone - blood ; Male ; Mice, Inbred ICR ; Mouse testis ; Proto-Oncogene Proteins c-bcl-2 - genetics ; Samarium - toxicity ; Samarium nitrate ; Testis - drug effects ; Testis - metabolism ; Testis - pathology ; Testosterone - blood ; Ultra-structure</subject><ispartof>Environmental toxicology and pharmacology, 2014-03, Vol.37 (2), p.505-512</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-b31ac120076f2233269daf7343e7469b9767ed08d47a9d288707400becb360443</citedby><cites>FETCH-LOGICAL-c477t-b31ac120076f2233269daf7343e7469b9767ed08d47a9d288707400becb360443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.etap.2014.01.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24561534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, De-Yong</creatorcontrib><creatorcontrib>Shen, Xiu-Ying</creatorcontrib><creatorcontrib>Ruan, Qin</creatorcontrib><creatorcontrib>Xu, Xiao-Lu</creatorcontrib><creatorcontrib>Yang, San-Ping</creatorcontrib><creatorcontrib>Lu, Yin</creatorcontrib><creatorcontrib>Xu, Hui-Ying</creatorcontrib><creatorcontrib>Hao, Fei-Lin</creatorcontrib><title>Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis</title><title>Environmental toxicology and pharmacology</title><addtitle>Environ Toxicol Pharmacol</addtitle><description>Highlights • Ninety days of subchronic exposure to samarium nitrate for mouse is performed for male reproductive toxicity evaluation. • Lesions in testis including disorganized seminiferous tubule, decreased spermatogenic cells, and so on are observed. • The lesions inside the cells involve mitochondria swelling, mitochondria vacuolization, fuzzy nuclear membrane, and so on. • Increased spermatogenic cell apoptosis is confirmed with TUNEL method, as well as changed expression level of Bax and Bcl-2 gene.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bcl-2</subject><subject>bcl-2-Associated X Protein - genetics</subject><subject>Emergency</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Mice, Inbred ICR</subject><subject>Mouse testis</subject><subject>Proto-Oncogene Proteins c-bcl-2 - genetics</subject><subject>Samarium - toxicity</subject><subject>Samarium nitrate</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>Testosterone - blood</subject><subject>Ultra-structure</subject><issn>1382-6689</issn><issn>1872-7077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQha0K1JbCC7BAXrJJ8N-NEwkhoaqllSqxANaW40x6fUni4LGr9u1xdAsLFqw8i3OO53xDyFvOas548-FQQ7JrLRhXNeM1Y_qEnPNWi0ozrV-UWbaiapq2OyOvEA-M8Z2U7Sk5E2rXlFmdE7waR3AJaRgp5t7tY1i8o2hnG32eKTyuAXMEGhaa9kD3HlNYbdqHKdx7ZyeKKWaXNoldBmrXsKaAHmmE-zzZ5IvRL3QOGYEmwOTxNXk52gnhzfN7QX5cX32_vKnuvn65vfx8Vzmldap6ya3jotRqRiGkFE032FFLJUGrpus73WgYWDsobbtBtG1prRjrwfWyYUrJC_L-mLvG8CuXr83s0cE02QXKOobveFEVPqJIxVHqYkCMMJo1-oLgyXBmNtjmYDbYZoNtGDdlq2J695yf-xmGv5Y_dIvg41EApeWDh2jQeVgcDD4W6GYI_v_5n_6xu8kvG_Sf8AR4CDkuhZ_hBoVh5tt27u3avFBgrG3lb9WApuM</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Zhang, De-Yong</creator><creator>Shen, Xiu-Ying</creator><creator>Ruan, Qin</creator><creator>Xu, Xiao-Lu</creator><creator>Yang, San-Ping</creator><creator>Lu, Yin</creator><creator>Xu, Hui-Ying</creator><creator>Hao, Fei-Lin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis</title><author>Zhang, De-Yong ; Shen, Xiu-Ying ; Ruan, Qin ; Xu, Xiao-Lu ; Yang, San-Ping ; Lu, Yin ; Xu, Hui-Ying ; Hao, Fei-Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-b31ac120076f2233269daf7343e7469b9767ed08d47a9d288707400becb360443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bcl-2</topic><topic>bcl-2-Associated X Protein - genetics</topic><topic>Emergency</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Mice, Inbred ICR</topic><topic>Mouse testis</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>Samarium - toxicity</topic><topic>Samarium nitrate</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Testis - pathology</topic><topic>Testosterone - blood</topic><topic>Ultra-structure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, De-Yong</creatorcontrib><creatorcontrib>Shen, Xiu-Ying</creatorcontrib><creatorcontrib>Ruan, Qin</creatorcontrib><creatorcontrib>Xu, Xiao-Lu</creatorcontrib><creatorcontrib>Yang, San-Ping</creatorcontrib><creatorcontrib>Lu, Yin</creatorcontrib><creatorcontrib>Xu, Hui-Ying</creatorcontrib><creatorcontrib>Hao, Fei-Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, De-Yong</au><au>Shen, Xiu-Ying</au><au>Ruan, Qin</au><au>Xu, Xiao-Lu</au><au>Yang, San-Ping</au><au>Lu, Yin</au><au>Xu, Hui-Ying</au><au>Hao, Fei-Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis</atitle><jtitle>Environmental toxicology and pharmacology</jtitle><addtitle>Environ Toxicol Pharmacol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>37</volume><issue>2</issue><spage>505</spage><epage>512</epage><pages>505-512</pages><issn>1382-6689</issn><eissn>1872-7077</eissn><abstract>Highlights • Ninety days of subchronic exposure to samarium nitrate for mouse is performed for male reproductive toxicity evaluation. • Lesions in testis including disorganized seminiferous tubule, decreased spermatogenic cells, and so on are observed. • The lesions inside the cells involve mitochondria swelling, mitochondria vacuolization, fuzzy nuclear membrane, and so on. • Increased spermatogenic cell apoptosis is confirmed with TUNEL method, as well as changed expression level of Bax and Bcl-2 gene.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24561534</pmid><doi>10.1016/j.etap.2014.01.007</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1382-6689 |
| ispartof | Environmental toxicology and pharmacology, 2014-03, Vol.37 (2), p.505-512 |
| issn | 1382-6689 1872-7077 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1514436682 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Apoptosis Apoptosis - drug effects Bcl-2 bcl-2-Associated X Protein - genetics Emergency Luteinizing Hormone - blood Male Mice, Inbred ICR Mouse testis Proto-Oncogene Proteins c-bcl-2 - genetics Samarium - toxicity Samarium nitrate Testis - drug effects Testis - metabolism Testis - pathology Testosterone - blood Ultra-structure |
| title | Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A16%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20subchronic%20samarium%20exposure%20on%20the%20histopathological%20structure%20and%20apoptosis%20regulation%20in%20mouse%20testis&rft.jtitle=Environmental%20toxicology%20and%20pharmacology&rft.au=Zhang,%20De-Yong&rft.date=2014-03-01&rft.volume=37&rft.issue=2&rft.spage=505&rft.epage=512&rft.pages=505-512&rft.issn=1382-6689&rft.eissn=1872-7077&rft_id=info:doi/10.1016/j.etap.2014.01.007&rft_dat=%3Cproquest_cross%3E1514436682%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1514436682&rft_id=info:pmid/24561534&rft_els_id=S1382668914000088&rfr_iscdi=true |