miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124

•We generated a gefitinib-resistant NSCLC cell model.•We identified significant downregulation of miR-138-5p using microarray analysis.•We found that the 3′UTR of the GPR124 mRNA is a target of miR-138-5p.•Restoration of miR-138-5p or knockdown of GPR124 overcomes gefitinib resistance. Epidermal gro...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-03, Vol.446 (1), p.179-186
Hauptverfasser:	Gao, Yi, Fan, XiaoWu, Li, WeiNa, Ping, Wei, Deng, Yu, Fu, XiangNing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma of Lung Antineoplastic Agents - pharmacology Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Down-Regulation Drug Resistance, Neoplasm - genetics Drug Resistance, Neoplasm - physiology G protein-coupled receptors Gefitinib Gefitinib resistance Gene Knockdown Techniques Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Non-small cell lung cancer Quinazolines - pharmacology Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Tyrosine kinase inhibitor
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