Clinical significance of serum epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) levels in patients with epithelial ovarian cancer
Cellular adhesion molecules might be good markers in some types of malignant tumors, useful information in diagnosis and prognosis. The objective of this study was to evaluate the serum levels of epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) in epithelial o...
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| Veröffentlicht in: | Tumor biology 2014-04, Vol.35 (4), p.3095-3102 |
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| creator | Tas, Faruk Karabulut, Senem Serilmez, Murat Ciftci, Rumeysa Duranyildiz, Derya |
| description | Cellular adhesion molecules might be good markers in some types of malignant tumors, useful information in diagnosis and prognosis. The objective of this study was to evaluate the serum levels of epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) in epithelial ovarian cancer (EOC) patients. Fifty patients were enrolled into the study. Serum EPCAM and VCAM-1 levels were determined by the solid-phase sandwich ELISA method. Age- and sex-matched 30 healthy controls were included in the analysis. The median age of the patients was 56.5 years, range 22 to 83 years. Majority of the patients had advanced disease (stages III–IV) (90 %). The baseline serum EPCAM levels of the EOC patients were significantly higher than in those in the control group (
p
= 0.03). However, there was no significant difference in the serum VCAM-1 level between EOC patients and controls (
p
= 0.24). Metastatic patients had higher serum VCAM-1 levels compared with the non-metastatic patients (
p
= 0.03). Moreover, no other clinical variables including response to chemotherapy were found to be correlated with both serum assays (
p
> 0.05). No correlation was found between serum EPCAM and VCAM-1 levels in EOC patients (
r
s
= 0.105,
p
= 0.362). Neither serum EPCAM level nor serum VCAM-1 level had significant adverse effect on survival. In conclusion, the higher baseline serum levels of VCAM-1 were associated with metastatic disease, and serum EPCAM level was found to be a diagnostic marker in EOC patients. However, both serum assays had no prognostic roles on outcome. |
| doi_str_mv | 10.1007/s13277-013-1401-z |
| format | Article |
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p
= 0.03). However, there was no significant difference in the serum VCAM-1 level between EOC patients and controls (
p
= 0.24). Metastatic patients had higher serum VCAM-1 levels compared with the non-metastatic patients (
p
= 0.03). Moreover, no other clinical variables including response to chemotherapy were found to be correlated with both serum assays (
p
> 0.05). No correlation was found between serum EPCAM and VCAM-1 levels in EOC patients (
r
s
= 0.105,
p
= 0.362). Neither serum EPCAM level nor serum VCAM-1 level had significant adverse effect on survival. In conclusion, the higher baseline serum levels of VCAM-1 were associated with metastatic disease, and serum EPCAM level was found to be a diagnostic marker in EOC patients. However, both serum assays had no prognostic roles on outcome.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-013-1401-z</identifier><identifier>PMID: 24307621</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigens, Neoplasm - blood ; Biomarkers ; Biomarkers, Tumor - blood ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Ovarian Epithelial ; Cell Adhesion Molecules - blood ; Epithelial Cell Adhesion Molecule ; Female ; Humans ; Medical diagnosis ; Metastasis ; Middle Aged ; Neoplasms, Glandular and Epithelial - blood ; Neoplasms, Glandular and Epithelial - diagnosis ; Neoplasms, Glandular and Epithelial - mortality ; Neoplasms, Glandular and Epithelial - pathology ; Ovarian cancer ; Ovarian Neoplasms - blood ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - mortality ; Ovarian Neoplasms - pathology ; Proteins ; Research Article ; Vascular Cell Adhesion Molecule-1 - blood</subject><ispartof>Tumor biology, 2014-04, Vol.35 (4), p.3095-3102</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2013</rights><rights>International Society of Oncology and BioMarkers (ISOBM) 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-4851c5326cfa6459a141ad16dd46f31f29c277505d701582631ee333218628a63</citedby><cites>FETCH-LOGICAL-c372t-4851c5326cfa6459a141ad16dd46f31f29c277505d701582631ee333218628a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-013-1401-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-013-1401-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24307621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tas, Faruk</creatorcontrib><creatorcontrib>Karabulut, Senem</creatorcontrib><creatorcontrib>Serilmez, Murat</creatorcontrib><creatorcontrib>Ciftci, Rumeysa</creatorcontrib><creatorcontrib>Duranyildiz, Derya</creatorcontrib><title>Clinical significance of serum epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) levels in patients with epithelial ovarian cancer</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>Cellular adhesion molecules might be good markers in some types of malignant tumors, useful information in diagnosis and prognosis. The objective of this study was to evaluate the serum levels of epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) in epithelial ovarian cancer (EOC) patients. Fifty patients were enrolled into the study. Serum EPCAM and VCAM-1 levels were determined by the solid-phase sandwich ELISA method. Age- and sex-matched 30 healthy controls were included in the analysis. The median age of the patients was 56.5 years, range 22 to 83 years. Majority of the patients had advanced disease (stages III–IV) (90 %). The baseline serum EPCAM levels of the EOC patients were significantly higher than in those in the control group (
p
= 0.03). However, there was no significant difference in the serum VCAM-1 level between EOC patients and controls (
p
= 0.24). Metastatic patients had higher serum VCAM-1 levels compared with the non-metastatic patients (
p
= 0.03). Moreover, no other clinical variables including response to chemotherapy were found to be correlated with both serum assays (
p
> 0.05). No correlation was found between serum EPCAM and VCAM-1 levels in EOC patients (
r
s
= 0.105,
p
= 0.362). Neither serum EPCAM level nor serum VCAM-1 level had significant adverse effect on survival. In conclusion, the higher baseline serum levels of VCAM-1 were associated with metastatic disease, and serum EPCAM level was found to be a diagnostic marker in EOC patients. However, both serum assays had no prognostic roles on outcome.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, Neoplasm - blood</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Ovarian Epithelial</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Epithelial Cell Adhesion Molecule</subject><subject>Female</subject><subject>Humans</subject><subject>Medical diagnosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasms, Glandular and Epithelial - blood</subject><subject>Neoplasms, Glandular and Epithelial - diagnosis</subject><subject>Neoplasms, Glandular and Epithelial - mortality</subject><subject>Neoplasms, Glandular and Epithelial - pathology</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Proteins</subject><subject>Research Article</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc9u1DAQxiMEoqXwAFyQJS7bg6nH4zjJsVqVP1IRPQBXyziT1pXjLHayiL4Rb4mXbasKqSeP7N9833i-qnoN4h0I0ZxkQNk0XAByUAL4zZPqEJRELrAVT0stQHAlWzyoXuR8LQTUXaefVwdSoWi0hMPqzzr46J0NLPvL6IdSRkdsGlimtIyMNn6-ouAL4CgEZvsryn6KbJwCuSUQW51drE8_HzMbe7a1udzZ9AjLga2-F5jDMQu0pZCZj2xjZ09xzuxXsXpoOG1t8jayfyOll9WzwYZMr27Po-rb-7Ov64_8_MuHT-vTc-6wkTNXbQ2uRqndYLWqOwsKbA-675UeEAbZubKzWtR9U9bRSo1AhIgSWi1bq_GoWu11N2n6uVCezejz7j820rRkAzUohVgLWdC3_6HX05JimW5HYYOguq5QsKdcmnJONJhN8qNNvw0Is8vR7HM0JUezy9HclJ43t8rLj5H6-4674Aog90AuT_GS0gPrR1X_AlQlp7w</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Tas, Faruk</creator><creator>Karabulut, Senem</creator><creator>Serilmez, Murat</creator><creator>Ciftci, Rumeysa</creator><creator>Duranyildiz, Derya</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Clinical significance of serum epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) levels in patients with epithelial ovarian cancer</title><author>Tas, Faruk ; Karabulut, Senem ; Serilmez, Murat ; Ciftci, Rumeysa ; Duranyildiz, Derya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-4851c5326cfa6459a141ad16dd46f31f29c277505d701582631ee333218628a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, Neoplasm - blood</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Ovarian Epithelial</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Epithelial Cell Adhesion Molecule</topic><topic>Female</topic><topic>Humans</topic><topic>Medical diagnosis</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasms, Glandular and Epithelial - blood</topic><topic>Neoplasms, Glandular and Epithelial - diagnosis</topic><topic>Neoplasms, Glandular and Epithelial - mortality</topic><topic>Neoplasms, Glandular and Epithelial - pathology</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Proteins</topic><topic>Research Article</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tas, Faruk</creatorcontrib><creatorcontrib>Karabulut, Senem</creatorcontrib><creatorcontrib>Serilmez, Murat</creatorcontrib><creatorcontrib>Ciftci, Rumeysa</creatorcontrib><creatorcontrib>Duranyildiz, Derya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tas, Faruk</au><au>Karabulut, Senem</au><au>Serilmez, Murat</au><au>Ciftci, Rumeysa</au><au>Duranyildiz, Derya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of serum epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) levels in patients with epithelial ovarian cancer</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>35</volume><issue>4</issue><spage>3095</spage><epage>3102</epage><pages>3095-3102</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>Cellular adhesion molecules might be good markers in some types of malignant tumors, useful information in diagnosis and prognosis. The objective of this study was to evaluate the serum levels of epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) in epithelial ovarian cancer (EOC) patients. Fifty patients were enrolled into the study. Serum EPCAM and VCAM-1 levels were determined by the solid-phase sandwich ELISA method. Age- and sex-matched 30 healthy controls were included in the analysis. The median age of the patients was 56.5 years, range 22 to 83 years. Majority of the patients had advanced disease (stages III–IV) (90 %). The baseline serum EPCAM levels of the EOC patients were significantly higher than in those in the control group (
p
= 0.03). However, there was no significant difference in the serum VCAM-1 level between EOC patients and controls (
p
= 0.24). Metastatic patients had higher serum VCAM-1 levels compared with the non-metastatic patients (
p
= 0.03). Moreover, no other clinical variables including response to chemotherapy were found to be correlated with both serum assays (
p
> 0.05). No correlation was found between serum EPCAM and VCAM-1 levels in EOC patients (
r
s
= 0.105,
p
= 0.362). Neither serum EPCAM level nor serum VCAM-1 level had significant adverse effect on survival. In conclusion, the higher baseline serum levels of VCAM-1 were associated with metastatic disease, and serum EPCAM level was found to be a diagnostic marker in EOC patients. However, both serum assays had no prognostic roles on outcome.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24307621</pmid><doi>10.1007/s13277-013-1401-z</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1010-4283 |
| ispartof | Tumor biology, 2014-04, Vol.35 (4), p.3095-3102 |
| issn | 1010-4283 1423-0380 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Antigens, Neoplasm - blood Biomarkers Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Ovarian Epithelial Cell Adhesion Molecules - blood Epithelial Cell Adhesion Molecule Female Humans Medical diagnosis Metastasis Middle Aged Neoplasms, Glandular and Epithelial - blood Neoplasms, Glandular and Epithelial - diagnosis Neoplasms, Glandular and Epithelial - mortality Neoplasms, Glandular and Epithelial - pathology Ovarian cancer Ovarian Neoplasms - blood Ovarian Neoplasms - diagnosis Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Proteins Research Article Vascular Cell Adhesion Molecule-1 - blood |
| title | Clinical significance of serum epithelial cell adhesion molecule (EPCAM) and vascular cell adhesion molecule-1 (VCAM-1) levels in patients with epithelial ovarian cancer |
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