F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation

Rac3 is a small GTPase multifunctional protein that regulates cell adhesion, migration, and differentiation. It has been considered as an oncogene in breast cancer; however, its role in esophageal cancer and the regulation of its stability have not been studied. F-box proteins are major subunits wit...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular cancer 2014-04, Vol.13, p.76-76
Hauptverfasser:	Dong, Su, Zhao, Jing, Wei, Jianxin, Bowser, Rachel K, Khoo, Andrew, Liu, Zhonghui, Luketich, James D, Pennathur, Arjun, Ma, Haichun, Zhao, Yutong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cadherins - biosynthesis Cadherins - genetics Cell Line, Tumor DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology F-Box Proteins - genetics F-Box Proteins - metabolism Gene Expression Regulation, Neoplastic Humans Proteolysis rac GTP-Binding Proteins - genetics Transforming Growth Factor beta1 - metabolism Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!