Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions
•Cymbopogon citratus is a well-known herbal medicinal plant for its essential oils.•The study highlights isolation, structure and biological activities of these polysaccharides.•Polysaccharides have anticancer activity in a time- and dose-dependent manner.•Polysaccharide fractions induced apoptosis...
Gespeichert in:
| Veröffentlicht in: | Carbohydrate polymers 2014-07, Vol.107, p.138-150 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 150 |
|---|---|
| container_issue | |
| container_start_page | 138 |
| container_title | Carbohydrate polymers |
| container_volume | 107 |
| creator | Thangam, Ramar Sathuvan, Malairaj Poongodi, Arasu Suresh, Veeraperumal Pazhanichamy, Kalailingam Sivasubramanian, Srinivasan Kanipandian, Nagarajan Ganesan, Nalini Rengasamy, Ramasamy Thirumurugan, Ramasamy Kannan, Soundarapandian |
| description | •Cymbopogon citratus is a well-known herbal medicinal plant for its essential oils.•The study highlights isolation, structure and biological activities of these polysaccharides.•Polysaccharides have anticancer activity in a time- and dose-dependent manner.•Polysaccharide fractions induced apoptosis in human cancer cells by the mitochondria mediated pathways.•Use of these plant polysaccharides as potential apoptosis inducing agents against cancer cells is discussed.
Essential oils of Cymbopogon citratus were already reported to have wide ranging medical and industrial applications. However, information on polysaccharides from the plant and their anticancer activities are limited. In the present study, polysaccharides from C. citratus were extracted and fractionated by anion exchange and gel filtration chromatography. Two different polysaccharide fractions such as F1 and F2 were obtained, and these fractions were found to have distinct acidic polysaccharides as characterized by their molecular weight and sugar content. NMR spectral analysis revealed the presence of (1→4) linked b-d-Xylofuranose moiety in these polysaccharides. Using these polysaccharide fractions F1 and F2, anti-inflammatory and anticancer activities were evaluated against cancer cells in vitro and the mechanism of action of the polysaccharides in inducing apoptosis in cancer cells via intrinsic pathway was also proposed. Two different reproductive cancer cells such as Siha and LNCap were employed for in vitro studies on cytotoxicity, induction of apoptosis and apoptotic DNA fragmentation, changes in mitochondrial membrane potential, and profiles of gene and protein expression in response to treatment of cells by the polysaccharide fractions. These polysaccharide fractions exhibited potential cytotoxic and apoptotic effects on carcinoma cells, and they induced apoptosis in these cells through the events of up-regulation of caspase 3, down-regulation of bcl-2 family genes followed by cytochrome c release. |
| doi_str_mv | 10.1016/j.carbpol.2014.02.039 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1514429163</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S014486171400160X</els_id><sourcerecordid>1514429163</sourcerecordid><originalsourceid>FETCH-LOGICAL-c395t-40f4758e7ec2a05b41e563288b0ae6d830ff2618a4fa8404d289f97db4e935b93</originalsourceid><addsrcrecordid>eNqFkE2P0zAQhi0EYsvCTwD5gsQlwV9J7BNaVXxJK3GBszVxnK6rNA4ed1H-PY5a4MhcPJKfmXn1EPKas5oz3r4_1g5Sv8SpFoyrmomaSfOE7LjuTMWlUk_JrnyoSre8uyEvEI-sVMvZc3IjVMeEEWZH8M7l8Ag5xJnGkYY5pzBjcBSWuOSYS4fhMMMU5gNdID_8grVQ1MHsfKLOTxPSfqX79dTHJR7KGhdygnxGWsKtCM49QAqDp2MCt93Bl-TZCBP6V9f3lvz49PH7_kt1_-3z1_3dfeWkaXKl2Ki6RvvOOwGs6RX3TSuF1j0D3w5asnEULdegRtCKqUFoM5pu6JU3sumNvCXvLnuXFH-ePWZ7CrglhtnHM1reFD_C8FYWtLmgLkXE5Ee7pHCCtFrO7ObbHu3Vt918WyZs8V3m3lxPnPuTH_5O_RFcgLdXANDBVBzMLuA_TsuWc7ZxHy6cL0Ieg08WXfDF8RCSd9kOMfwnym-UaqMo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1514429163</pqid></control><display><type>article</type><title>Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Thangam, Ramar ; Sathuvan, Malairaj ; Poongodi, Arasu ; Suresh, Veeraperumal ; Pazhanichamy, Kalailingam ; Sivasubramanian, Srinivasan ; Kanipandian, Nagarajan ; Ganesan, Nalini ; Rengasamy, Ramasamy ; Thirumurugan, Ramasamy ; Kannan, Soundarapandian</creator><creatorcontrib>Thangam, Ramar ; Sathuvan, Malairaj ; Poongodi, Arasu ; Suresh, Veeraperumal ; Pazhanichamy, Kalailingam ; Sivasubramanian, Srinivasan ; Kanipandian, Nagarajan ; Ganesan, Nalini ; Rengasamy, Ramasamy ; Thirumurugan, Ramasamy ; Kannan, Soundarapandian</creatorcontrib><description>•Cymbopogon citratus is a well-known herbal medicinal plant for its essential oils.•The study highlights isolation, structure and biological activities of these polysaccharides.•Polysaccharides have anticancer activity in a time- and dose-dependent manner.•Polysaccharide fractions induced apoptosis in human cancer cells by the mitochondria mediated pathways.•Use of these plant polysaccharides as potential apoptosis inducing agents against cancer cells is discussed.
Essential oils of Cymbopogon citratus were already reported to have wide ranging medical and industrial applications. However, information on polysaccharides from the plant and their anticancer activities are limited. In the present study, polysaccharides from C. citratus were extracted and fractionated by anion exchange and gel filtration chromatography. Two different polysaccharide fractions such as F1 and F2 were obtained, and these fractions were found to have distinct acidic polysaccharides as characterized by their molecular weight and sugar content. NMR spectral analysis revealed the presence of (1→4) linked b-d-Xylofuranose moiety in these polysaccharides. Using these polysaccharide fractions F1 and F2, anti-inflammatory and anticancer activities were evaluated against cancer cells in vitro and the mechanism of action of the polysaccharides in inducing apoptosis in cancer cells via intrinsic pathway was also proposed. Two different reproductive cancer cells such as Siha and LNCap were employed for in vitro studies on cytotoxicity, induction of apoptosis and apoptotic DNA fragmentation, changes in mitochondrial membrane potential, and profiles of gene and protein expression in response to treatment of cells by the polysaccharide fractions. These polysaccharide fractions exhibited potential cytotoxic and apoptotic effects on carcinoma cells, and they induced apoptosis in these cells through the events of up-regulation of caspase 3, down-regulation of bcl-2 family genes followed by cytochrome c release.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2014.02.039</identifier><identifier>PMID: 24702929</identifier><identifier>CODEN: CAPOD8</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Antineoplastic agents ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; Applied sciences ; Biological and medical sciences ; Biomarkers, Tumor - genetics ; Cancer cells ; Caspase 3 - metabolism ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chemotherapy ; Cymbopogon - chemistry ; Cymbopogon citratus ; Cytotoxicity ; DNA Fragmentation - drug effects ; Dose-Response Relationship, Drug ; Enzyme Activation - drug effects ; Exact sciences and technology ; Gene expression ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; Intrinsic apoptotic pathway ; Medical sciences ; Membrane Potential, Mitochondrial - drug effects ; Molecular Weight ; Natural polymers ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Plant polysaccharide ; Polysaccharides - chemistry ; Polysaccharides - pharmacology ; Signal Transduction - drug effects ; Starch and polysaccharides ; Time Factors ; Xylofuranose</subject><ispartof>Carbohydrate polymers, 2014-07, Vol.107, p.138-150</ispartof><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-40f4758e7ec2a05b41e563288b0ae6d830ff2618a4fa8404d289f97db4e935b93</citedby><cites>FETCH-LOGICAL-c395t-40f4758e7ec2a05b41e563288b0ae6d830ff2618a4fa8404d289f97db4e935b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2014.02.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28361109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24702929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thangam, Ramar</creatorcontrib><creatorcontrib>Sathuvan, Malairaj</creatorcontrib><creatorcontrib>Poongodi, Arasu</creatorcontrib><creatorcontrib>Suresh, Veeraperumal</creatorcontrib><creatorcontrib>Pazhanichamy, Kalailingam</creatorcontrib><creatorcontrib>Sivasubramanian, Srinivasan</creatorcontrib><creatorcontrib>Kanipandian, Nagarajan</creatorcontrib><creatorcontrib>Ganesan, Nalini</creatorcontrib><creatorcontrib>Rengasamy, Ramasamy</creatorcontrib><creatorcontrib>Thirumurugan, Ramasamy</creatorcontrib><creatorcontrib>Kannan, Soundarapandian</creatorcontrib><title>Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>•Cymbopogon citratus is a well-known herbal medicinal plant for its essential oils.•The study highlights isolation, structure and biological activities of these polysaccharides.•Polysaccharides have anticancer activity in a time- and dose-dependent manner.•Polysaccharide fractions induced apoptosis in human cancer cells by the mitochondria mediated pathways.•Use of these plant polysaccharides as potential apoptosis inducing agents against cancer cells is discussed.
Essential oils of Cymbopogon citratus were already reported to have wide ranging medical and industrial applications. However, information on polysaccharides from the plant and their anticancer activities are limited. In the present study, polysaccharides from C. citratus were extracted and fractionated by anion exchange and gel filtration chromatography. Two different polysaccharide fractions such as F1 and F2 were obtained, and these fractions were found to have distinct acidic polysaccharides as characterized by their molecular weight and sugar content. NMR spectral analysis revealed the presence of (1→4) linked b-d-Xylofuranose moiety in these polysaccharides. Using these polysaccharide fractions F1 and F2, anti-inflammatory and anticancer activities were evaluated against cancer cells in vitro and the mechanism of action of the polysaccharides in inducing apoptosis in cancer cells via intrinsic pathway was also proposed. Two different reproductive cancer cells such as Siha and LNCap were employed for in vitro studies on cytotoxicity, induction of apoptosis and apoptotic DNA fragmentation, changes in mitochondrial membrane potential, and profiles of gene and protein expression in response to treatment of cells by the polysaccharide fractions. These polysaccharide fractions exhibited potential cytotoxic and apoptotic effects on carcinoma cells, and they induced apoptosis in these cells through the events of up-regulation of caspase 3, down-regulation of bcl-2 family genes followed by cytochrome c release.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cancer cells</subject><subject>Caspase 3 - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemotherapy</subject><subject>Cymbopogon - chemistry</subject><subject>Cymbopogon citratus</subject><subject>Cytotoxicity</subject><subject>DNA Fragmentation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Activation - drug effects</subject><subject>Exact sciences and technology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Humans</subject><subject>Intrinsic apoptotic pathway</subject><subject>Medical sciences</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Molecular Weight</subject><subject>Natural polymers</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Plant polysaccharide</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - pharmacology</subject><subject>Signal Transduction - drug effects</subject><subject>Starch and polysaccharides</subject><subject>Time Factors</subject><subject>Xylofuranose</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2P0zAQhi0EYsvCTwD5gsQlwV9J7BNaVXxJK3GBszVxnK6rNA4ed1H-PY5a4MhcPJKfmXn1EPKas5oz3r4_1g5Sv8SpFoyrmomaSfOE7LjuTMWlUk_JrnyoSre8uyEvEI-sVMvZc3IjVMeEEWZH8M7l8Ag5xJnGkYY5pzBjcBSWuOSYS4fhMMMU5gNdID_8grVQ1MHsfKLOTxPSfqX79dTHJR7KGhdygnxGWsKtCM49QAqDp2MCt93Bl-TZCBP6V9f3lvz49PH7_kt1_-3z1_3dfeWkaXKl2Ki6RvvOOwGs6RX3TSuF1j0D3w5asnEULdegRtCKqUFoM5pu6JU3sumNvCXvLnuXFH-ePWZ7CrglhtnHM1reFD_C8FYWtLmgLkXE5Ee7pHCCtFrO7ObbHu3Vt918WyZs8V3m3lxPnPuTH_5O_RFcgLdXANDBVBzMLuA_TsuWc7ZxHy6cL0Ieg08WXfDF8RCSd9kOMfwnym-UaqMo</recordid><startdate>20140717</startdate><enddate>20140717</enddate><creator>Thangam, Ramar</creator><creator>Sathuvan, Malairaj</creator><creator>Poongodi, Arasu</creator><creator>Suresh, Veeraperumal</creator><creator>Pazhanichamy, Kalailingam</creator><creator>Sivasubramanian, Srinivasan</creator><creator>Kanipandian, Nagarajan</creator><creator>Ganesan, Nalini</creator><creator>Rengasamy, Ramasamy</creator><creator>Thirumurugan, Ramasamy</creator><creator>Kannan, Soundarapandian</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140717</creationdate><title>Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions</title><author>Thangam, Ramar ; Sathuvan, Malairaj ; Poongodi, Arasu ; Suresh, Veeraperumal ; Pazhanichamy, Kalailingam ; Sivasubramanian, Srinivasan ; Kanipandian, Nagarajan ; Ganesan, Nalini ; Rengasamy, Ramasamy ; Thirumurugan, Ramasamy ; Kannan, Soundarapandian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-40f4758e7ec2a05b41e563288b0ae6d830ff2618a4fa8404d289f97db4e935b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cancer cells</topic><topic>Caspase 3 - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Chemotherapy</topic><topic>Cymbopogon - chemistry</topic><topic>Cymbopogon citratus</topic><topic>Cytotoxicity</topic><topic>DNA Fragmentation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Activation - drug effects</topic><topic>Exact sciences and technology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Humans</topic><topic>Intrinsic apoptotic pathway</topic><topic>Medical sciences</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Molecular Weight</topic><topic>Natural polymers</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Plant polysaccharide</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - pharmacology</topic><topic>Signal Transduction - drug effects</topic><topic>Starch and polysaccharides</topic><topic>Time Factors</topic><topic>Xylofuranose</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thangam, Ramar</creatorcontrib><creatorcontrib>Sathuvan, Malairaj</creatorcontrib><creatorcontrib>Poongodi, Arasu</creatorcontrib><creatorcontrib>Suresh, Veeraperumal</creatorcontrib><creatorcontrib>Pazhanichamy, Kalailingam</creatorcontrib><creatorcontrib>Sivasubramanian, Srinivasan</creatorcontrib><creatorcontrib>Kanipandian, Nagarajan</creatorcontrib><creatorcontrib>Ganesan, Nalini</creatorcontrib><creatorcontrib>Rengasamy, Ramasamy</creatorcontrib><creatorcontrib>Thirumurugan, Ramasamy</creatorcontrib><creatorcontrib>Kannan, Soundarapandian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thangam, Ramar</au><au>Sathuvan, Malairaj</au><au>Poongodi, Arasu</au><au>Suresh, Veeraperumal</au><au>Pazhanichamy, Kalailingam</au><au>Sivasubramanian, Srinivasan</au><au>Kanipandian, Nagarajan</au><au>Ganesan, Nalini</au><au>Rengasamy, Ramasamy</au><au>Thirumurugan, Ramasamy</au><au>Kannan, Soundarapandian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2014-07-17</date><risdate>2014</risdate><volume>107</volume><spage>138</spage><epage>150</epage><pages>138-150</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>•Cymbopogon citratus is a well-known herbal medicinal plant for its essential oils.•The study highlights isolation, structure and biological activities of these polysaccharides.•Polysaccharides have anticancer activity in a time- and dose-dependent manner.•Polysaccharide fractions induced apoptosis in human cancer cells by the mitochondria mediated pathways.•Use of these plant polysaccharides as potential apoptosis inducing agents against cancer cells is discussed.
Essential oils of Cymbopogon citratus were already reported to have wide ranging medical and industrial applications. However, information on polysaccharides from the plant and their anticancer activities are limited. In the present study, polysaccharides from C. citratus were extracted and fractionated by anion exchange and gel filtration chromatography. Two different polysaccharide fractions such as F1 and F2 were obtained, and these fractions were found to have distinct acidic polysaccharides as characterized by their molecular weight and sugar content. NMR spectral analysis revealed the presence of (1→4) linked b-d-Xylofuranose moiety in these polysaccharides. Using these polysaccharide fractions F1 and F2, anti-inflammatory and anticancer activities were evaluated against cancer cells in vitro and the mechanism of action of the polysaccharides in inducing apoptosis in cancer cells via intrinsic pathway was also proposed. Two different reproductive cancer cells such as Siha and LNCap were employed for in vitro studies on cytotoxicity, induction of apoptosis and apoptotic DNA fragmentation, changes in mitochondrial membrane potential, and profiles of gene and protein expression in response to treatment of cells by the polysaccharide fractions. These polysaccharide fractions exhibited potential cytotoxic and apoptotic effects on carcinoma cells, and they induced apoptosis in these cells through the events of up-regulation of caspase 3, down-regulation of bcl-2 family genes followed by cytochrome c release.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24702929</pmid><doi>10.1016/j.carbpol.2014.02.039</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0144-8617 |
| ispartof | Carbohydrate polymers, 2014-07, Vol.107, p.138-150 |
| issn | 0144-8617 1879-1344 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1514429163 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Applied sciences Biological and medical sciences Biomarkers, Tumor - genetics Cancer cells Caspase 3 - metabolism Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cymbopogon - chemistry Cymbopogon citratus Cytotoxicity DNA Fragmentation - drug effects Dose-Response Relationship, Drug Enzyme Activation - drug effects Exact sciences and technology Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans Intrinsic apoptotic pathway Medical sciences Membrane Potential, Mitochondrial - drug effects Molecular Weight Natural polymers Pharmacology. Drug treatments Physicochemistry of polymers Plant polysaccharide Polysaccharides - chemistry Polysaccharides - pharmacology Signal Transduction - drug effects Starch and polysaccharides Time Factors Xylofuranose |
| title | Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T14%3A49%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Activation%20of%20intrinsic%20apoptotic%20signaling%20pathway%20in%20cancer%20cells%20by%20Cymbopogon%20citratus%20polysaccharide%20fractions&rft.jtitle=Carbohydrate%20polymers&rft.au=Thangam,%20Ramar&rft.date=2014-07-17&rft.volume=107&rft.spage=138&rft.epage=150&rft.pages=138-150&rft.issn=0144-8617&rft.eissn=1879-1344&rft.coden=CAPOD8&rft_id=info:doi/10.1016/j.carbpol.2014.02.039&rft_dat=%3Cproquest_cross%3E1514429163%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1514429163&rft_id=info:pmid/24702929&rft_els_id=S014486171400160X&rfr_iscdi=true |