Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression
Aims/hypothesis Vitamin D deficiency is common in people with type 1 diabetes, but its role in disease progression is unclear. Our aim was to assess the prevalence of vitamin D deficiency in prediabetes (defined as the presence of multiple islet autoantibodies), and investigate whether or not progre...
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| Veröffentlicht in: | Diabetologia 2014-05, Vol.57 (5), p.902-908 |
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| container_title | Diabetologia |
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| creator | Raab, Jennifer Giannopoulou, Eleni Z. Schneider, Simone Warncke, Katharina Krasmann, Miriam Winkler, Christiane Ziegler, Anette-Gabriele |
| description | Aims/hypothesis
Vitamin D deficiency is common in people with type 1 diabetes, but its role in disease progression is unclear. Our aim was to assess the prevalence of vitamin D deficiency in prediabetes (defined as the presence of multiple islet autoantibodies), and investigate whether or not progression to type 1 diabetes is faster in children with vitamin D deficiency and multiple islet autoantibodies.
Methods
Levels of 25-hydroxyvitamin D [25(OH)D] were measured in 108 children with multiple islet autoantibodies within 2 years of islet autoantibody seroconversion, in 406 children who remained islet autoantibody-negative and in 244 patients with newly diagnosed type 1 diabetes. Children with multiple islet autoantibodies were prospectively followed for a median of 5.8 years (interquartile range 3.4–8.6 years) to monitor progression to type 1 diabetes.
Results
In the cross-sectional analysis, 25(OH)D levels were lower and the prevalence of vitamin D deficiency ( |
| doi_str_mv | 10.1007/s00125-014-3181-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1514428544</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3269455881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-7862b659c016d03cec4899fd2e85ef0099e16fde0fd047f7ca1db1fe88f8425b3</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7uzqD_AiARH2Eq2kk-70UdZPWNCDgreQTiprlp7uMdWzMv_eNDN-IHgqkvept4p6GXsi4YUE6F4SgFRGgNSikVYKfY9tpG6UAK3sfbZZZSFt-_WMnRPdAkBjdPuQnSltGqnaZsPSp4J3fsQpIJ8Tv8uL3-aJv-YRUw65_h94fe8KiuWwQy55zH7ABYn7KfK81Eo0h-yXPE_8R16-VYLQE9am-aYgURUesQfJj4SPT_WCfXn75vPVe3H98d2Hq1fXImhQi-hsq4bW9AFkG6EJGLTt-xQVWoMJoO9RtikipAi6S13wMg4yobXJamWG5oJdHn3r7O97pMVtMwUcRz_hvCcnjdT1Nkbrij77B72d92Wq261U06m-hb5S8kiFMhMVTG5X8taXg5Pg1hDcMQRXQ3BrCG51fnpy3g9bjL87fl29As9PgKfgx1T8FDL94azpdQdd5dSRoypNN1j-WvG_038C60uelw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1513729609</pqid></control><display><type>article</type><title>Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Raab, Jennifer ; Giannopoulou, Eleni Z. ; Schneider, Simone ; Warncke, Katharina ; Krasmann, Miriam ; Winkler, Christiane ; Ziegler, Anette-Gabriele</creator><creatorcontrib>Raab, Jennifer ; Giannopoulou, Eleni Z. ; Schneider, Simone ; Warncke, Katharina ; Krasmann, Miriam ; Winkler, Christiane ; Ziegler, Anette-Gabriele</creatorcontrib><description>Aims/hypothesis
Vitamin D deficiency is common in people with type 1 diabetes, but its role in disease progression is unclear. Our aim was to assess the prevalence of vitamin D deficiency in prediabetes (defined as the presence of multiple islet autoantibodies), and investigate whether or not progression to type 1 diabetes is faster in children with vitamin D deficiency and multiple islet autoantibodies.
Methods
Levels of 25-hydroxyvitamin D [25(OH)D] were measured in 108 children with multiple islet autoantibodies within 2 years of islet autoantibody seroconversion, in 406 children who remained islet autoantibody-negative and in 244 patients with newly diagnosed type 1 diabetes. Children with multiple islet autoantibodies were prospectively followed for a median of 5.8 years (interquartile range 3.4–8.6 years) to monitor progression to type 1 diabetes.
Results
In the cross-sectional analysis, 25(OH)D levels were lower and the prevalence of vitamin D deficiency (<50 nmol/l) was higher in children with prevalent multiple islet autoantibodies than in islet autoantibody-negative children (59.9 ± 3.0 vs 71.9 ± 1.5 nmol/l;
p
< 0.001; 39.8% vs 28.3%;
p
= 0.021). The differences in vitamin D levels between the groups were greatest in summer. The cumulative incidence of type 1 diabetes at 10 years after seroconversion was similar between children with vitamin D deficiency and those with sufficient vitamin D levels (51.8% [95% CI 29.3, 74.3] vs 55.4% [95% CI 35.5, 72.3],
p
= 0.8).
Conclusions/interpretation
Vitamin D levels were lower in children with multiple islet autoantibodies and in children with type 1 diabetes than in autoantibody-negative children. However, vitamin D deficiency was not associated with faster progression to type 1 diabetes in children with multiple islet autoantibodies.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-014-3181-4</identifier><identifier>PMID: 24531263</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autoantibodies - chemistry ; Biological and medical sciences ; Child ; Child, Preschool ; Children & youth ; Cohort Studies ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Disease Progression ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Human Physiology ; Humans ; Incidence ; Internal Medicine ; Islets of Langerhans - immunology ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Prediabetic State - blood ; Prediabetic State - complications ; Time Factors ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D - chemistry ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin deficiency</subject><ispartof>Diabetologia, 2014-05, Vol.57 (5), p.902-908</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-7862b659c016d03cec4899fd2e85ef0099e16fde0fd047f7ca1db1fe88f8425b3</citedby><cites>FETCH-LOGICAL-c402t-7862b659c016d03cec4899fd2e85ef0099e16fde0fd047f7ca1db1fe88f8425b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00125-014-3181-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00125-014-3181-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28594707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24531263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raab, Jennifer</creatorcontrib><creatorcontrib>Giannopoulou, Eleni Z.</creatorcontrib><creatorcontrib>Schneider, Simone</creatorcontrib><creatorcontrib>Warncke, Katharina</creatorcontrib><creatorcontrib>Krasmann, Miriam</creatorcontrib><creatorcontrib>Winkler, Christiane</creatorcontrib><creatorcontrib>Ziegler, Anette-Gabriele</creatorcontrib><title>Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description>Aims/hypothesis
Vitamin D deficiency is common in people with type 1 diabetes, but its role in disease progression is unclear. Our aim was to assess the prevalence of vitamin D deficiency in prediabetes (defined as the presence of multiple islet autoantibodies), and investigate whether or not progression to type 1 diabetes is faster in children with vitamin D deficiency and multiple islet autoantibodies.
Methods
Levels of 25-hydroxyvitamin D [25(OH)D] were measured in 108 children with multiple islet autoantibodies within 2 years of islet autoantibody seroconversion, in 406 children who remained islet autoantibody-negative and in 244 patients with newly diagnosed type 1 diabetes. Children with multiple islet autoantibodies were prospectively followed for a median of 5.8 years (interquartile range 3.4–8.6 years) to monitor progression to type 1 diabetes.
Results
In the cross-sectional analysis, 25(OH)D levels were lower and the prevalence of vitamin D deficiency (<50 nmol/l) was higher in children with prevalent multiple islet autoantibodies than in islet autoantibody-negative children (59.9 ± 3.0 vs 71.9 ± 1.5 nmol/l;
p
< 0.001; 39.8% vs 28.3%;
p
= 0.021). The differences in vitamin D levels between the groups were greatest in summer. The cumulative incidence of type 1 diabetes at 10 years after seroconversion was similar between children with vitamin D deficiency and those with sufficient vitamin D levels (51.8% [95% CI 29.3, 74.3] vs 55.4% [95% CI 35.5, 72.3],
p
= 0.8).
Conclusions/interpretation
Vitamin D levels were lower in children with multiple islet autoantibodies and in children with type 1 diabetes than in autoantibody-negative children. However, vitamin D deficiency was not associated with faster progression to type 1 diabetes in children with multiple islet autoantibodies.</description><subject>Autoantibodies - chemistry</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Disease Progression</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Islets of Langerhans - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Prediabetic State - blood</subject><subject>Prediabetic State - complications</subject><subject>Time Factors</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - chemistry</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin deficiency</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU2LFDEQhoMo7uzqD_AiARH2Eq2kk-70UdZPWNCDgreQTiprlp7uMdWzMv_eNDN-IHgqkvept4p6GXsi4YUE6F4SgFRGgNSikVYKfY9tpG6UAK3sfbZZZSFt-_WMnRPdAkBjdPuQnSltGqnaZsPSp4J3fsQpIJ8Tv8uL3-aJv-YRUw65_h94fe8KiuWwQy55zH7ABYn7KfK81Eo0h-yXPE_8R16-VYLQE9am-aYgURUesQfJj4SPT_WCfXn75vPVe3H98d2Hq1fXImhQi-hsq4bW9AFkG6EJGLTt-xQVWoMJoO9RtikipAi6S13wMg4yobXJamWG5oJdHn3r7O97pMVtMwUcRz_hvCcnjdT1Nkbrij77B72d92Wq261U06m-hb5S8kiFMhMVTG5X8taXg5Pg1hDcMQRXQ3BrCG51fnpy3g9bjL87fl29As9PgKfgx1T8FDL94azpdQdd5dSRoypNN1j-WvG_038C60uelw</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Raab, Jennifer</creator><creator>Giannopoulou, Eleni Z.</creator><creator>Schneider, Simone</creator><creator>Warncke, Katharina</creator><creator>Krasmann, Miriam</creator><creator>Winkler, Christiane</creator><creator>Ziegler, Anette-Gabriele</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression</title><author>Raab, Jennifer ; Giannopoulou, Eleni Z. ; Schneider, Simone ; Warncke, Katharina ; Krasmann, Miriam ; Winkler, Christiane ; Ziegler, Anette-Gabriele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-7862b659c016d03cec4899fd2e85ef0099e16fde0fd047f7ca1db1fe88f8425b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Autoantibodies - chemistry</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Disease Progression</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Islets of Langerhans - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Prediabetic State - blood</topic><topic>Prediabetic State - complications</topic><topic>Time Factors</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - chemistry</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raab, Jennifer</creatorcontrib><creatorcontrib>Giannopoulou, Eleni Z.</creatorcontrib><creatorcontrib>Schneider, Simone</creatorcontrib><creatorcontrib>Warncke, Katharina</creatorcontrib><creatorcontrib>Krasmann, Miriam</creatorcontrib><creatorcontrib>Winkler, Christiane</creatorcontrib><creatorcontrib>Ziegler, Anette-Gabriele</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raab, Jennifer</au><au>Giannopoulou, Eleni Z.</au><au>Schneider, Simone</au><au>Warncke, Katharina</au><au>Krasmann, Miriam</au><au>Winkler, Christiane</au><au>Ziegler, Anette-Gabriele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>57</volume><issue>5</issue><spage>902</spage><epage>908</epage><pages>902-908</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Aims/hypothesis
Vitamin D deficiency is common in people with type 1 diabetes, but its role in disease progression is unclear. Our aim was to assess the prevalence of vitamin D deficiency in prediabetes (defined as the presence of multiple islet autoantibodies), and investigate whether or not progression to type 1 diabetes is faster in children with vitamin D deficiency and multiple islet autoantibodies.
Methods
Levels of 25-hydroxyvitamin D [25(OH)D] were measured in 108 children with multiple islet autoantibodies within 2 years of islet autoantibody seroconversion, in 406 children who remained islet autoantibody-negative and in 244 patients with newly diagnosed type 1 diabetes. Children with multiple islet autoantibodies were prospectively followed for a median of 5.8 years (interquartile range 3.4–8.6 years) to monitor progression to type 1 diabetes.
Results
In the cross-sectional analysis, 25(OH)D levels were lower and the prevalence of vitamin D deficiency (<50 nmol/l) was higher in children with prevalent multiple islet autoantibodies than in islet autoantibody-negative children (59.9 ± 3.0 vs 71.9 ± 1.5 nmol/l;
p
< 0.001; 39.8% vs 28.3%;
p
= 0.021). The differences in vitamin D levels between the groups were greatest in summer. The cumulative incidence of type 1 diabetes at 10 years after seroconversion was similar between children with vitamin D deficiency and those with sufficient vitamin D levels (51.8% [95% CI 29.3, 74.3] vs 55.4% [95% CI 35.5, 72.3],
p
= 0.8).
Conclusions/interpretation
Vitamin D levels were lower in children with multiple islet autoantibodies and in children with type 1 diabetes than in autoantibody-negative children. However, vitamin D deficiency was not associated with faster progression to type 1 diabetes in children with multiple islet autoantibodies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24531263</pmid><doi>10.1007/s00125-014-3181-4</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Diabetologia, 2014-05, Vol.57 (5), p.902-908 |
| issn | 0012-186X 1432-0428 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Autoantibodies - chemistry Biological and medical sciences Child Child, Preschool Children & youth Cohort Studies Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Disease Progression Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Human Physiology Humans Incidence Internal Medicine Islets of Langerhans - immunology Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Prediabetic State - blood Prediabetic State - complications Time Factors Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - chemistry Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin deficiency |
| title | Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression |
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