Gender-specific associations of the APOA1 −75G>A polymorphism with several metabolic syndrome components in Turkish adults
Variations in the apolipoprotein A-1 (APOA1) gene, a determinant of plasma high-density lipoprotein cholesterol (HDL-C) and apoA-I levels, may contribute to cardiovascular diseases. We evaluated the effects of a promoter polymorphism (−75G>A) in the APOA1 gene on metabolic syndrome (MetS) compone...
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| Veröffentlicht in: | Clinica chimica acta 2014-04, Vol.431, p.244-249 |
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| container_title | Clinica chimica acta |
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| creator | Coban, Neslihan Onat, Altan Guclu-Geyik, Filiz Komurcu-Bayrak, Evrim Can, Gunay Erginel-Unaltuna, Nihan |
| description | Variations in the apolipoprotein A-1 (APOA1) gene, a determinant of plasma high-density lipoprotein cholesterol (HDL-C) and apoA-I levels, may contribute to cardiovascular diseases. We evaluated the effects of a promoter polymorphism (−75G>A) in the APOA1 gene on metabolic syndrome (MetS) components in a Turkish population sample.
Randomly selected 1515 Turkish adults (age 49.9±11.8years, 785 females) were genotyped for −75G>A polymorphism using hybridization probes in Real-Time PCR LC480 device. MetS and atherogenic dyslipidemia were defined using the criteria of ATP III.
The −75AA genotype prevailed in 3.9% of men and 2.4% of women, and was independently associated with significantly higher HDL-C concentrations. Independent associations with the −75GA genotype existed only in men: higher diastolic and systolic blood pressure (BP) levels (pA polymorphism is independently related to HDL-C concentrations. Independent associations of the −75GA genotype with elevated BP and atherogenic dyslipidemia were confined to men. These gender-modulated associations suggest novel gene–gender–environmental interactions.
•Gender specific association of APOA1 gene with MetS traits risk.•75G>A polymorphism influences serum HDL-C levels among Turkish adults.•APOA1 −75GA genotype is independently related to atherogenic dyslipidemia.•Male −75A allele carriers had significantly higher diastolic BP.•Gender-modulated associations suggest novel gene-gender-environmental interactions. |
| doi_str_mv | 10.1016/j.cca.2014.01.017 |
| format | Article |
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Randomly selected 1515 Turkish adults (age 49.9±11.8years, 785 females) were genotyped for −75G>A polymorphism using hybridization probes in Real-Time PCR LC480 device. MetS and atherogenic dyslipidemia were defined using the criteria of ATP III.
The −75AA genotype prevailed in 3.9% of men and 2.4% of women, and was independently associated with significantly higher HDL-C concentrations. Independent associations with the −75GA genotype existed only in men: higher diastolic and systolic blood pressure (BP) levels (p<0.05) were observed in male −75GA heterozygotes. Logistic regression revealed that the GA genotype confers elevated risk for atherogenic dyslipidemia (OR=1.57, 95% Cl 1.06–2.3) after adjustment for associated risk factors. Independent associations with atherogenic dyslipidemia or elevated BP did not emerge in women.
APOA1 −75G>A polymorphism is independently related to HDL-C concentrations. Independent associations of the −75GA genotype with elevated BP and atherogenic dyslipidemia were confined to men. These gender-modulated associations suggest novel gene–gender–environmental interactions.
•Gender specific association of APOA1 gene with MetS traits risk.•75G>A polymorphism influences serum HDL-C levels among Turkish adults.•APOA1 −75GA genotype is independently related to atherogenic dyslipidemia.•Male −75A allele carriers had significantly higher diastolic BP.•Gender-modulated associations suggest novel gene-gender-environmental interactions.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2014.01.017</identifier><identifier>PMID: 24508624</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Apolipoprotein A-I - genetics ; Apolipoprotein A1 ; Atherogenic dyslipidemia ; Blood Glucose - metabolism ; Blood Pressure ; Dyslipidemias - blood ; Dyslipidemias - genetics ; Female ; Genotype ; HDL-C ; Humans ; Lipids - blood ; Male ; Metabolic Syndrome - genetics ; Metabolic Syndrome - physiopathology ; Middle Aged ; Obesity - genetics ; Polymorphism ; Polymorphism, Genetic - genetics ; Sex Characteristics ; Turkey - epidemiology</subject><ispartof>Clinica chimica acta, 2014-04, Vol.431, p.244-249</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-3ebcb9584ed8c6bdfb7cee73ee93d2f2f8080ee8f34c3c21ae3e15bbbd258b4c3</citedby><cites>FETCH-LOGICAL-c353t-3ebcb9584ed8c6bdfb7cee73ee93d2f2f8080ee8f34c3c21ae3e15bbbd258b4c3</cites><orcidid>0000-0003-1255-4265</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cca.2014.01.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24508624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coban, Neslihan</creatorcontrib><creatorcontrib>Onat, Altan</creatorcontrib><creatorcontrib>Guclu-Geyik, Filiz</creatorcontrib><creatorcontrib>Komurcu-Bayrak, Evrim</creatorcontrib><creatorcontrib>Can, Gunay</creatorcontrib><creatorcontrib>Erginel-Unaltuna, Nihan</creatorcontrib><title>Gender-specific associations of the APOA1 −75G>A polymorphism with several metabolic syndrome components in Turkish adults</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Variations in the apolipoprotein A-1 (APOA1) gene, a determinant of plasma high-density lipoprotein cholesterol (HDL-C) and apoA-I levels, may contribute to cardiovascular diseases. We evaluated the effects of a promoter polymorphism (−75G>A) in the APOA1 gene on metabolic syndrome (MetS) components in a Turkish population sample.
Randomly selected 1515 Turkish adults (age 49.9±11.8years, 785 females) were genotyped for −75G>A polymorphism using hybridization probes in Real-Time PCR LC480 device. MetS and atherogenic dyslipidemia were defined using the criteria of ATP III.
The −75AA genotype prevailed in 3.9% of men and 2.4% of women, and was independently associated with significantly higher HDL-C concentrations. Independent associations with the −75GA genotype existed only in men: higher diastolic and systolic blood pressure (BP) levels (p<0.05) were observed in male −75GA heterozygotes. Logistic regression revealed that the GA genotype confers elevated risk for atherogenic dyslipidemia (OR=1.57, 95% Cl 1.06–2.3) after adjustment for associated risk factors. Independent associations with atherogenic dyslipidemia or elevated BP did not emerge in women.
APOA1 −75G>A polymorphism is independently related to HDL-C concentrations. Independent associations of the −75GA genotype with elevated BP and atherogenic dyslipidemia were confined to men. These gender-modulated associations suggest novel gene–gender–environmental interactions.
•Gender specific association of APOA1 gene with MetS traits risk.•75G>A polymorphism influences serum HDL-C levels among Turkish adults.•APOA1 −75GA genotype is independently related to atherogenic dyslipidemia.•Male −75A allele carriers had significantly higher diastolic BP.•Gender-modulated associations suggest novel gene-gender-environmental interactions.</description><subject>Adult</subject><subject>Apolipoprotein A-I - genetics</subject><subject>Apolipoprotein A1</subject><subject>Atherogenic dyslipidemia</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>HDL-C</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Metabolic Syndrome - genetics</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Middle Aged</subject><subject>Obesity - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Sex Characteristics</subject><subject>Turkey - epidemiology</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1qFEEUhQsxmDH6AG6klm56rL-erkYQhqCjEEgWybqon9tMjd1dbd3uyIAP4NpH9EmsMNFl4MDlXs45cD9C3nC25oxv3h_W3tu1YFytGS9qnpEV142spGrFc7JijLWVbjU_Jy8RD2VVbMNfkHOhaqY3Qq3Izx2MAXKFE_jYRU8tYvLRzjGNSFNH5z3Q7c31ltM_v3439e7jlk6pPw4pT_uIA_0R5z1FuIdsezrAbF3qSw0ex5DTANSnYUojjDPSONLbJX-LuKc2LP2Mr8hZZ3uE14_zgtx9_nR7-aW6ut59vdxeVV7Wcq4kOO_aWisI2m9c6FzjARoJ0MogOtFpphmA7qTy0gtuQQKvnXNB1NqV2wV5d-qdcvq-AM5miOih7-0IaUHDa66UaKRoi5WfrD4nxAydmXIcbD4azswDdHMwBbp5gG4YL2pK5u1j_eIGCP8T_ygXw4eTAcqT9xGyQR9h9BBiBj-bkOIT9X8BhMqVuA</recordid><startdate>20140420</startdate><enddate>20140420</enddate><creator>Coban, Neslihan</creator><creator>Onat, Altan</creator><creator>Guclu-Geyik, Filiz</creator><creator>Komurcu-Bayrak, Evrim</creator><creator>Can, Gunay</creator><creator>Erginel-Unaltuna, Nihan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1255-4265</orcidid></search><sort><creationdate>20140420</creationdate><title>Gender-specific associations of the APOA1 −75G>A polymorphism with several metabolic syndrome components in Turkish adults</title><author>Coban, Neslihan ; Onat, Altan ; Guclu-Geyik, Filiz ; Komurcu-Bayrak, Evrim ; Can, Gunay ; Erginel-Unaltuna, Nihan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-3ebcb9584ed8c6bdfb7cee73ee93d2f2f8080ee8f34c3c21ae3e15bbbd258b4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Apolipoprotein A-I - genetics</topic><topic>Apolipoprotein A1</topic><topic>Atherogenic dyslipidemia</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>HDL-C</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Metabolic Syndrome - genetics</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Middle Aged</topic><topic>Obesity - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Sex Characteristics</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coban, Neslihan</creatorcontrib><creatorcontrib>Onat, Altan</creatorcontrib><creatorcontrib>Guclu-Geyik, Filiz</creatorcontrib><creatorcontrib>Komurcu-Bayrak, Evrim</creatorcontrib><creatorcontrib>Can, Gunay</creatorcontrib><creatorcontrib>Erginel-Unaltuna, Nihan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coban, Neslihan</au><au>Onat, Altan</au><au>Guclu-Geyik, Filiz</au><au>Komurcu-Bayrak, Evrim</au><au>Can, Gunay</au><au>Erginel-Unaltuna, Nihan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender-specific associations of the APOA1 −75G>A polymorphism with several metabolic syndrome components in Turkish adults</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2014-04-20</date><risdate>2014</risdate><volume>431</volume><spage>244</spage><epage>249</epage><pages>244-249</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Variations in the apolipoprotein A-1 (APOA1) gene, a determinant of plasma high-density lipoprotein cholesterol (HDL-C) and apoA-I levels, may contribute to cardiovascular diseases. We evaluated the effects of a promoter polymorphism (−75G>A) in the APOA1 gene on metabolic syndrome (MetS) components in a Turkish population sample.
Randomly selected 1515 Turkish adults (age 49.9±11.8years, 785 females) were genotyped for −75G>A polymorphism using hybridization probes in Real-Time PCR LC480 device. MetS and atherogenic dyslipidemia were defined using the criteria of ATP III.
The −75AA genotype prevailed in 3.9% of men and 2.4% of women, and was independently associated with significantly higher HDL-C concentrations. Independent associations with the −75GA genotype existed only in men: higher diastolic and systolic blood pressure (BP) levels (p<0.05) were observed in male −75GA heterozygotes. Logistic regression revealed that the GA genotype confers elevated risk for atherogenic dyslipidemia (OR=1.57, 95% Cl 1.06–2.3) after adjustment for associated risk factors. Independent associations with atherogenic dyslipidemia or elevated BP did not emerge in women.
APOA1 −75G>A polymorphism is independently related to HDL-C concentrations. Independent associations of the −75GA genotype with elevated BP and atherogenic dyslipidemia were confined to men. These gender-modulated associations suggest novel gene–gender–environmental interactions.
•Gender specific association of APOA1 gene with MetS traits risk.•75G>A polymorphism influences serum HDL-C levels among Turkish adults.•APOA1 −75GA genotype is independently related to atherogenic dyslipidemia.•Male −75A allele carriers had significantly higher diastolic BP.•Gender-modulated associations suggest novel gene-gender-environmental interactions.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24508624</pmid><doi>10.1016/j.cca.2014.01.017</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1255-4265</orcidid></addata></record> |
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| ispartof | Clinica chimica acta, 2014-04, Vol.431, p.244-249 |
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| subjects | Adult Apolipoprotein A-I - genetics Apolipoprotein A1 Atherogenic dyslipidemia Blood Glucose - metabolism Blood Pressure Dyslipidemias - blood Dyslipidemias - genetics Female Genotype HDL-C Humans Lipids - blood Male Metabolic Syndrome - genetics Metabolic Syndrome - physiopathology Middle Aged Obesity - genetics Polymorphism Polymorphism, Genetic - genetics Sex Characteristics Turkey - epidemiology |
| title | Gender-specific associations of the APOA1 −75G>A polymorphism with several metabolic syndrome components in Turkish adults |
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