Intrinsic cardiac adrenergic (ICA) cell density and MAO-A activity in failing rat hearts

The efficiency (work/oxygen consumption) of isolated papillary muscles from failing hearts is reduced. We investigated whether this can be due to an increase of intrinsic cardiac adrenergic (ICA) cell density. The number of ICA cells in the septum and both ventricular walls was determined by tyrosin...

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Veröffentlicht in:	Journal of muscle research and cell motility 2014-02, Vol.35 (1), p.47-53
Hauptverfasser:	van Eif, Vincent W. W., Bogaards, Sylvia J. P., van der Laarse, Willem J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Count Clorgyline - pharmacology Disease Models, Animal Heart Failure - enzymology Heart Failure - metabolism Heart Failure - pathology Histology Life Sciences Male Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology Morphology Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Norepinephrine - metabolism Original Paper Oxygen Consumption Proteomics Rats Rats, Wistar
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Zusammenfassung:	The efficiency (work/oxygen consumption) of isolated papillary muscles from failing hearts is reduced. We investigated whether this can be due to an increase of intrinsic cardiac adrenergic (ICA) cell density. The number of ICA cells in the septum and both ventricular walls was determined by tyrosine hydroxylase immunohistochemistry in rats with monocrotaline-induced pulmonary hypertension. We found that the number of ICA cells is about 200,000 per rat heart. ICA cell density was significantly lower in right ventricular myocardium of hypertrophied hearts ( P
ISSN:	0142-4319 1573-2657
DOI:	10.1007/s10974-013-9373-6