Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion

Urokinase plasminogen activator (uPA) and its receptor (uPAR) coordinate a plasmin-mediated proteolytic cascade that has been implicated in cell adhesion, cell motility, and matrix breakdown, for example, during inflammation. As part of their function during inflammatory responses, macrophages move...

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Veröffentlicht in:The Journal of immunology (1950) 2014-04, Vol.192 (8), p.3540-3547
Hauptverfasser: Fleetwood, Andrew J, Achuthan, Adrian, Schultz, Heidi, Nansen, Anneline, Almholt, Kasper, Usher, Pernille, Hamilton, John A
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Sprache:eng
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