Radiofrequency ablation of thoracic tumours: lessons learned with ablation of 100 lesions
Purpose Our aim was to analyse the results of our first 100 radiofrequency ablation (RFA) procedures, of primary (nonsmall-cell lung cancers, NSCLC) and secondary (MTS) lung cancers to assess what lessons could be learned from our experience. Materials and methods We analysed 100 lesions (mean size...
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| Veröffentlicht in: | Radiologia medica 2014, Vol.119 (1), p.33-40 |
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| creator | Garetto, Irene Busso, Marco Sardo, Diego Filippini, Claudia Solitro, Federica Grognardi, Maria Luisa Veltri, Andrea |
| description | Purpose
Our aim was to analyse the results of our first 100 radiofrequency ablation (RFA) procedures, of primary (nonsmall-cell lung cancers, NSCLC) and secondary (MTS) lung cancers to assess what lessons could be learned from our experience.
Materials and methods
We analysed 100 lesions (mean size 23 mm) in 81 patients (25 NSCLC/56 MTS). On the basis of the clinical–radiological evolution, we analysed complete ablation (CA) versus partial ablation (PA) at the first computed tomography (CT) scan and during the follow-up (mean 23 months), time to progression (TTP) and survival. Possible predictive factors for local effectiveness and survival were sought.
Results
At the first CT scan CA was obtained in 88 %; the difference between the mean diameter of lesions achieving CA and PA was significant (20 versus 38 mm;
p
= 0.0001). A threshold of 30 mm (
p
= 0.0030) and the histological type (NSCLC 75 %/MTS 94 %;
p
= 0.0305) were also predictive of CA. A total of 18.4 % of the CA recurred (average TTP 19 months). Survival at 1, 2 and 3 years was 84.5, 65.4 and 51.5 %, respectively. The predictors of survival at 3 years were the coexistence of other MTS (
p
= 0.0422) and a diameter |
| doi_str_mv | 10.1007/s11547-013-0308-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1514424812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1514424812</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-4db01cd7f6b9ba3f37dc8789f87a51a658332e42acdc54f446c204a99ba25bde3</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMozjj6AG6kSzfRXNvUnQzeYEAQXbgKaS5Oh7YZkxaZtzelo-DG1eGQ7__J-QA4x-gKI1RcR4w5KyDCFCKKBOQHYI4FyWFeCnoI5ghRCgXNyQycxLhBiCGMymMwI4xQhgWfg_cXZWrvgv0cbKd3maoa1de-y7zL-rUPStc664fWDyHeZI2N0XcxTRU6a7Kvul__iaRvjVDa4ik4cqqJ9mw_F-Dt_u51-QhXzw9Py9sV1JSxHjJTIaxN4fKqrBR1tDBaFKJ0olAcq5wLSollRGmjOXOM5ZogpsoEE14ZSxfgcurdBp-OiL1s66ht06jO-iFKzDFjhAlMEoonVAcfY7BObkPdqrCTGMnRqJyMymRUjkYlT5mLff1Qtdb8Jn4UJoBMQExP3YcNcpNkdenkf1q_AXtygY8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1514424812</pqid></control><display><type>article</type><title>Radiofrequency ablation of thoracic tumours: lessons learned with ablation of 100 lesions</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Garetto, Irene ; Busso, Marco ; Sardo, Diego ; Filippini, Claudia ; Solitro, Federica ; Grognardi, Maria Luisa ; Veltri, Andrea</creator><creatorcontrib>Garetto, Irene ; Busso, Marco ; Sardo, Diego ; Filippini, Claudia ; Solitro, Federica ; Grognardi, Maria Luisa ; Veltri, Andrea</creatorcontrib><description>Purpose
Our aim was to analyse the results of our first 100 radiofrequency ablation (RFA) procedures, of primary (nonsmall-cell lung cancers, NSCLC) and secondary (MTS) lung cancers to assess what lessons could be learned from our experience.
Materials and methods
We analysed 100 lesions (mean size 23 mm) in 81 patients (25 NSCLC/56 MTS). On the basis of the clinical–radiological evolution, we analysed complete ablation (CA) versus partial ablation (PA) at the first computed tomography (CT) scan and during the follow-up (mean 23 months), time to progression (TTP) and survival. Possible predictive factors for local effectiveness and survival were sought.
Results
At the first CT scan CA was obtained in 88 %; the difference between the mean diameter of lesions achieving CA and PA was significant (20 versus 38 mm;
p
= 0.0001). A threshold of 30 mm (
p
= 0.0030) and the histological type (NSCLC 75 %/MTS 94 %;
p
= 0.0305) were also predictive of CA. A total of 18.4 % of the CA recurred (average TTP 19 months). Survival at 1, 2 and 3 years was 84.5, 65.4 and 51.5 %, respectively. The predictors of survival at 3 years were the coexistence of other MTS (
p
= 0.0422) and a diameter <20 mm (
p
= 0.0323), but not the local effectiveness of RFA.
Conclusion
RFA for thoracic malignancies is accurate for lesions up to 30 mm, especially if metastatic; survival is more closely related to staging factors than to the local effectiveness of RFA.</description><identifier>ISSN: 0033-8362</identifier><identifier>EISSN: 1826-6983</identifier><identifier>DOI: 10.1007/s11547-013-0308-5</identifier><identifier>PMID: 24234185</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - surgery ; Catheter Ablation - methods ; Chest Radiology ; Diagnostic Radiology ; Disease Progression ; Female ; Humans ; Imaging ; Interventional Radiology ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Patient Selection ; Postoperative Complications - diagnostic imaging ; Radiology ; Retrospective Studies ; Survival Rate ; Tomography, X-Ray Computed ; Treatment Outcome ; Ultrasound</subject><ispartof>Radiologia medica, 2014, Vol.119 (1), p.33-40</ispartof><rights>Italian Society of Medical Radiology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-4db01cd7f6b9ba3f37dc8789f87a51a658332e42acdc54f446c204a99ba25bde3</citedby><cites>FETCH-LOGICAL-c344t-4db01cd7f6b9ba3f37dc8789f87a51a658332e42acdc54f446c204a99ba25bde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11547-013-0308-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11547-013-0308-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24234185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garetto, Irene</creatorcontrib><creatorcontrib>Busso, Marco</creatorcontrib><creatorcontrib>Sardo, Diego</creatorcontrib><creatorcontrib>Filippini, Claudia</creatorcontrib><creatorcontrib>Solitro, Federica</creatorcontrib><creatorcontrib>Grognardi, Maria Luisa</creatorcontrib><creatorcontrib>Veltri, Andrea</creatorcontrib><title>Radiofrequency ablation of thoracic tumours: lessons learned with ablation of 100 lesions</title><title>Radiologia medica</title><addtitle>Radiol med</addtitle><addtitle>Radiol Med</addtitle><description>Purpose
Our aim was to analyse the results of our first 100 radiofrequency ablation (RFA) procedures, of primary (nonsmall-cell lung cancers, NSCLC) and secondary (MTS) lung cancers to assess what lessons could be learned from our experience.
Materials and methods
We analysed 100 lesions (mean size 23 mm) in 81 patients (25 NSCLC/56 MTS). On the basis of the clinical–radiological evolution, we analysed complete ablation (CA) versus partial ablation (PA) at the first computed tomography (CT) scan and during the follow-up (mean 23 months), time to progression (TTP) and survival. Possible predictive factors for local effectiveness and survival were sought.
Results
At the first CT scan CA was obtained in 88 %; the difference between the mean diameter of lesions achieving CA and PA was significant (20 versus 38 mm;
p
= 0.0001). A threshold of 30 mm (
p
= 0.0030) and the histological type (NSCLC 75 %/MTS 94 %;
p
= 0.0305) were also predictive of CA. A total of 18.4 % of the CA recurred (average TTP 19 months). Survival at 1, 2 and 3 years was 84.5, 65.4 and 51.5 %, respectively. The predictors of survival at 3 years were the coexistence of other MTS (
p
= 0.0422) and a diameter <20 mm (
p
= 0.0323), but not the local effectiveness of RFA.
Conclusion
RFA for thoracic malignancies is accurate for lesions up to 30 mm, especially if metastatic; survival is more closely related to staging factors than to the local effectiveness of RFA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Catheter Ablation - methods</subject><subject>Chest Radiology</subject><subject>Diagnostic Radiology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Patient Selection</subject><subject>Postoperative Complications - diagnostic imaging</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>Ultrasound</subject><issn>0033-8362</issn><issn>1826-6983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMozjj6AG6kSzfRXNvUnQzeYEAQXbgKaS5Oh7YZkxaZtzelo-DG1eGQ7__J-QA4x-gKI1RcR4w5KyDCFCKKBOQHYI4FyWFeCnoI5ghRCgXNyQycxLhBiCGMymMwI4xQhgWfg_cXZWrvgv0cbKd3maoa1de-y7zL-rUPStc664fWDyHeZI2N0XcxTRU6a7Kvul__iaRvjVDa4ik4cqqJ9mw_F-Dt_u51-QhXzw9Py9sV1JSxHjJTIaxN4fKqrBR1tDBaFKJ0olAcq5wLSollRGmjOXOM5ZogpsoEE14ZSxfgcurdBp-OiL1s66ht06jO-iFKzDFjhAlMEoonVAcfY7BObkPdqrCTGMnRqJyMymRUjkYlT5mLff1Qtdb8Jn4UJoBMQExP3YcNcpNkdenkf1q_AXtygY8</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Garetto, Irene</creator><creator>Busso, Marco</creator><creator>Sardo, Diego</creator><creator>Filippini, Claudia</creator><creator>Solitro, Federica</creator><creator>Grognardi, Maria Luisa</creator><creator>Veltri, Andrea</creator><general>Springer Milan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Radiofrequency ablation of thoracic tumours: lessons learned with ablation of 100 lesions</title><author>Garetto, Irene ; Busso, Marco ; Sardo, Diego ; Filippini, Claudia ; Solitro, Federica ; Grognardi, Maria Luisa ; Veltri, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-4db01cd7f6b9ba3f37dc8789f87a51a658332e42acdc54f446c204a99ba25bde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Catheter Ablation - methods</topic><topic>Chest Radiology</topic><topic>Diagnostic Radiology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Patient Selection</topic><topic>Postoperative Complications - diagnostic imaging</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garetto, Irene</creatorcontrib><creatorcontrib>Busso, Marco</creatorcontrib><creatorcontrib>Sardo, Diego</creatorcontrib><creatorcontrib>Filippini, Claudia</creatorcontrib><creatorcontrib>Solitro, Federica</creatorcontrib><creatorcontrib>Grognardi, Maria Luisa</creatorcontrib><creatorcontrib>Veltri, Andrea</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiologia medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garetto, Irene</au><au>Busso, Marco</au><au>Sardo, Diego</au><au>Filippini, Claudia</au><au>Solitro, Federica</au><au>Grognardi, Maria Luisa</au><au>Veltri, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiofrequency ablation of thoracic tumours: lessons learned with ablation of 100 lesions</atitle><jtitle>Radiologia medica</jtitle><stitle>Radiol med</stitle><addtitle>Radiol Med</addtitle><date>2014</date><risdate>2014</risdate><volume>119</volume><issue>1</issue><spage>33</spage><epage>40</epage><pages>33-40</pages><issn>0033-8362</issn><eissn>1826-6983</eissn><abstract>Purpose
Our aim was to analyse the results of our first 100 radiofrequency ablation (RFA) procedures, of primary (nonsmall-cell lung cancers, NSCLC) and secondary (MTS) lung cancers to assess what lessons could be learned from our experience.
Materials and methods
We analysed 100 lesions (mean size 23 mm) in 81 patients (25 NSCLC/56 MTS). On the basis of the clinical–radiological evolution, we analysed complete ablation (CA) versus partial ablation (PA) at the first computed tomography (CT) scan and during the follow-up (mean 23 months), time to progression (TTP) and survival. Possible predictive factors for local effectiveness and survival were sought.
Results
At the first CT scan CA was obtained in 88 %; the difference between the mean diameter of lesions achieving CA and PA was significant (20 versus 38 mm;
p
= 0.0001). A threshold of 30 mm (
p
= 0.0030) and the histological type (NSCLC 75 %/MTS 94 %;
p
= 0.0305) were also predictive of CA. A total of 18.4 % of the CA recurred (average TTP 19 months). Survival at 1, 2 and 3 years was 84.5, 65.4 and 51.5 %, respectively. The predictors of survival at 3 years were the coexistence of other MTS (
p
= 0.0422) and a diameter <20 mm (
p
= 0.0323), but not the local effectiveness of RFA.
Conclusion
RFA for thoracic malignancies is accurate for lesions up to 30 mm, especially if metastatic; survival is more closely related to staging factors than to the local effectiveness of RFA.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>24234185</pmid><doi>10.1007/s11547-013-0308-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | Radiologia medica, 2014, Vol.119 (1), p.33-40 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - surgery Catheter Ablation - methods Chest Radiology Diagnostic Radiology Disease Progression Female Humans Imaging Interventional Radiology Lung Neoplasms - diagnostic imaging Lung Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Neuroradiology Patient Selection Postoperative Complications - diagnostic imaging Radiology Retrospective Studies Survival Rate Tomography, X-Ray Computed Treatment Outcome Ultrasound |
| title | Radiofrequency ablation of thoracic tumours: lessons learned with ablation of 100 lesions |
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