Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome
The acquired immunodeficiency syndrome (AIDS) is caused by infection with the human immunodeficiency virus (HIV). Currently, the only licensed agent shown to be effective in prolonging life in symptomatic patients infected with HIV is zidovudine (azidothymidine, AZT, 3'-azido-3'-deoxythymi...
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| Veröffentlicht in: | The American journal of medicine 1988-09, Vol.85 (3), p.428-431 |
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| container_end_page | 431 |
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| container_issue | 3 |
| container_start_page | 428 |
| container_title | The American journal of medicine |
| container_volume | 85 |
| creator | Roberts, Douglas E. Berman, Stephen M. Nakasato, Sharlene Wyle, Frederic A. Wishnow, Rodney M. Segal, Gary P. |
| description | The acquired immunodeficiency syndrome (AIDS) is caused by infection with the human immunodeficiency virus (HIV). Currently, the only licensed agent shown to be effective in prolonging life in symptomatic patients infected with HIV is zidovudine (azidothymidine, AZT, 3'-azido-3'-deoxythymidine). Zidovudine is, however, associated with significant side effects. Lithium carbonate has been shown to cause sustained leukocytosis and neutrophilia in hematologically normal patients with psychiatric disease. The authors report the effects of lithium on neutropenia associated with zidovudine therapy in five patients with AIDS. |
| doi_str_mv | 10.1016/0002-9343(88)90601-8 |
| format | Article |
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Currently, the only licensed agent shown to be effective in prolonging life in symptomatic patients infected with HIV is zidovudine (azidothymidine, AZT, 3'-azido-3'-deoxythymidine). Zidovudine is, however, associated with significant side effects. Lithium carbonate has been shown to cause sustained leukocytosis and neutrophilia in hematologically normal patients with psychiatric disease. The authors report the effects of lithium on neutropenia associated with zidovudine therapy in five patients with AIDS.</description><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - drug therapy</subject><subject>Adult</subject><subject>Agranulocytosis - chemically induced</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Lithium - therapeutic use</subject><subject>Lithium Carbonate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutropenia - chemically induced</subject><subject>Neutrophils - drug effects</subject><subject>Thymidine - adverse effects</subject><subject>Thymidine - analogs & derivatives</subject><subject>Zidovudine</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWj_-gUJOoofVZLPZzV4EkfoBBS96DmkywZRu0ia7hfrrTT_o0dMw874zw_sgdE3JAyW0fiSElEXLKnYnxH1LakILcYRGlHNeNLQuj9HoYDlD5ynNcktaXp-iU0ZZI2g7QrOxtaB7HCyeu_7HDR3WKk6DVz3g4PGvM2E1GOehUCkF7fLcYA9DH8MCvFPYedz_AFZ6ObiYNdd1gw8GrNMOvF7jtPYmhg4u0YlV8wRX-3qBvl_HXy_vxeTz7ePleVJoJkRfcG4Nb0pTlbwUvOFqqojWwGpGCKcVK2vWQqmsUZQzqFiOAlOmoM2RGkotu0C3u7uLGJYDpF52LmmYz5WHMCRJOWWiFiQbq51Rx5BSBCsX0XUqriUlcoNYbvjJDT8phNwiliKv3ezvD9MOzGFpzzTrTzsdcsiVgyjTlgSYzEf30gT3_4M_DoiMCQ</recordid><startdate>19880901</startdate><enddate>19880901</enddate><creator>Roberts, Douglas E.</creator><creator>Berman, Stephen M.</creator><creator>Nakasato, Sharlene</creator><creator>Wyle, Frederic A.</creator><creator>Wishnow, Rodney M.</creator><creator>Segal, Gary P.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>19880901</creationdate><title>Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome</title><author>Roberts, Douglas E. ; Berman, Stephen M. ; Nakasato, Sharlene ; Wyle, Frederic A. ; Wishnow, Rodney M. ; Segal, Gary P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-55fd572d42528575aba0cce3630051432639e2afda153e43313eb3ae9137711f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - drug therapy</topic><topic>Adult</topic><topic>Agranulocytosis - chemically induced</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Lithium - therapeutic use</topic><topic>Lithium Carbonate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutropenia - chemically induced</topic><topic>Neutrophils - drug effects</topic><topic>Thymidine - adverse effects</topic><topic>Thymidine - analogs & derivatives</topic><topic>Zidovudine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, Douglas E.</creatorcontrib><creatorcontrib>Berman, Stephen M.</creatorcontrib><creatorcontrib>Nakasato, Sharlene</creatorcontrib><creatorcontrib>Wyle, Frederic A.</creatorcontrib><creatorcontrib>Wishnow, Rodney M.</creatorcontrib><creatorcontrib>Segal, Gary P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, Douglas E.</au><au>Berman, Stephen M.</au><au>Nakasato, Sharlene</au><au>Wyle, Frederic A.</au><au>Wishnow, Rodney M.</au><au>Segal, Gary P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1988-09-01</date><risdate>1988</risdate><volume>85</volume><issue>3</issue><spage>428</spage><epage>431</epage><pages>428-431</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>The acquired immunodeficiency syndrome (AIDS) is caused by infection with the human immunodeficiency virus (HIV). Currently, the only licensed agent shown to be effective in prolonging life in symptomatic patients infected with HIV is zidovudine (azidothymidine, AZT, 3'-azido-3'-deoxythymidine). Zidovudine is, however, associated with significant side effects. Lithium carbonate has been shown to cause sustained leukocytosis and neutrophilia in hematologically normal patients with psychiatric disease. The authors report the effects of lithium on neutropenia associated with zidovudine therapy in five patients with AIDS.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3137819</pmid><doi>10.1016/0002-9343(88)90601-8</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9343 |
| ispartof | The American journal of medicine, 1988-09, Vol.85 (3), p.428-431 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - drug therapy Adult Agranulocytosis - chemically induced Humans Leukocyte Count Lithium - therapeutic use Lithium Carbonate Male Middle Aged Neutropenia - chemically induced Neutrophils - drug effects Thymidine - adverse effects Thymidine - analogs & derivatives Zidovudine |
| title | Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome |
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