Investigating the Role of Relaxin in the Regulation of Airway Fibrosis in Animal Models of Acute and Chronic Allergic Airway Disease
: Airway remodeling is a characteristic feature of asthma that leads to chronic irreversible airway obstruction. Fibrosis in the basement membrane region is a hallmark of remodeling in asthma that is not found in other diseases. In the outlined studies, we investigated the relationship between relax...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2005-05, Vol.1041 (1), p.194-196 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | MOOKERJEE, ISHANEE TANG, MIMI L.K. SOLLY, NATASHA TREGEAR, GEOFFREY W. SAMUEL, CHRISHAN S. |
| description | : Airway remodeling is a characteristic feature of asthma that leads to chronic irreversible airway obstruction. Fibrosis in the basement membrane region is a hallmark of remodeling in asthma that is not found in other diseases. In the outlined studies, we investigated the relationship between relaxin and airway fibrosis in asthma using acute and chronic models of allergic airway disease. These studies confirm a critical role for relaxin, in the regulation of collagen deposition in the airway/lung in animal models of allergic airway disease. |
| doi_str_mv | 10.1196/annals.1282.029 |
| format | Article |
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Fibrosis in the basement membrane region is a hallmark of remodeling in asthma that is not found in other diseases. In the outlined studies, we investigated the relationship between relaxin and airway fibrosis in asthma using acute and chronic models of allergic airway disease. These studies confirm a critical role for relaxin, in the regulation of collagen deposition in the airway/lung in animal models of allergic airway disease.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1282.029</identifier><identifier>PMID: 15956707</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>acute and chronic allergic airway disease ; Acute Disease ; airway/lung fibrosis ; Airways ; Animals ; Asthma ; Commercial aircraft ; Commercial planes ; Control ; Disease Models, Animal ; Fibrosis ; Hypersensitivity - metabolism ; Hypersensitivity - pathology ; Mice ; Mice, Knockout ; Ovalbumin - pharmacology ; Pulmonary Disease, Chronic Obstructive - chemically induced ; Pulmonary Disease, Chronic Obstructive - metabolism ; Pulmonary Disease, Chronic Obstructive - pathology ; Pulmonary Fibrosis - metabolism ; Pulmonary Fibrosis - pathology ; relaxin ; Relaxin - deficiency ; Relaxin - genetics ; Relaxin - metabolism ; relaxin-1 knockout mice ; Remodeling</subject><ispartof>Annals of the New York Academy of Sciences, 2005-05, Vol.1041 (1), p.194-196</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4114-37fecef8889be3a86adc95cdd650c996c7da663e8005b593ff4cde26858252c13</citedby><cites>FETCH-LOGICAL-c4114-37fecef8889be3a86adc95cdd650c996c7da663e8005b593ff4cde26858252c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1282.029$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1282.029$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15956707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOOKERJEE, ISHANEE</creatorcontrib><creatorcontrib>TANG, MIMI L.K.</creatorcontrib><creatorcontrib>SOLLY, NATASHA</creatorcontrib><creatorcontrib>TREGEAR, GEOFFREY W.</creatorcontrib><creatorcontrib>SAMUEL, CHRISHAN S.</creatorcontrib><title>Investigating the Role of Relaxin in the Regulation of Airway Fibrosis in Animal Models of Acute and Chronic Allergic Airway Disease</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: Airway remodeling is a characteristic feature of asthma that leads to chronic irreversible airway obstruction. Fibrosis in the basement membrane region is a hallmark of remodeling in asthma that is not found in other diseases. In the outlined studies, we investigated the relationship between relaxin and airway fibrosis in asthma using acute and chronic models of allergic airway disease. These studies confirm a critical role for relaxin, in the regulation of collagen deposition in the airway/lung in animal models of allergic airway disease.</description><subject>acute and chronic allergic airway disease</subject><subject>Acute Disease</subject><subject>airway/lung fibrosis</subject><subject>Airways</subject><subject>Animals</subject><subject>Asthma</subject><subject>Commercial aircraft</subject><subject>Commercial planes</subject><subject>Control</subject><subject>Disease Models, Animal</subject><subject>Fibrosis</subject><subject>Hypersensitivity - metabolism</subject><subject>Hypersensitivity - pathology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Ovalbumin - pharmacology</subject><subject>Pulmonary Disease, Chronic Obstructive - chemically induced</subject><subject>Pulmonary Disease, Chronic Obstructive - metabolism</subject><subject>Pulmonary Disease, Chronic Obstructive - pathology</subject><subject>Pulmonary Fibrosis - metabolism</subject><subject>Pulmonary Fibrosis - pathology</subject><subject>relaxin</subject><subject>Relaxin - deficiency</subject><subject>Relaxin - genetics</subject><subject>Relaxin - metabolism</subject><subject>relaxin-1 knockout mice</subject><subject>Remodeling</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAUhS0EotOWNTvkJZtM7SR-LaOBPtSZglpQxcryODdTg8cpcdJ29v3hOM0IlkhX8tX1d450DkLvKZlTqviJCcH4OKe5zOckV6_QjIpSZZwX-Ws0I0SITKq8OECHMf4kJHGleIsOKFOMCyJm6PkiPEDs3cb0Lmxwfwf4uvWA2wZfgzdPLuA0L2fYDD5RbRg_K9c9mh0-deuujS6OUBXc1ni8amvw8YWxQw_YhBov7ro2OIsr76HbjMsk_-QimAjH6E2TYsC7_XuEvp9-_rY4z5Zfzi4W1TKzJaVlVogGLDRSSrWGwkhuaquYrWvOiFWKW1GblBwkIWzNVNE0pa0h55LJnOWWFkfo4-R737W_hxRbb1204L0J0A5RU0YLRnJRkoSeTKhN-WIHjb7vUrxupynRY_V6ql6P1etUfVJ82JsP6y3U__h91wkoJ-DRedj9z09f_ahuqCqTLJtkLvbw9Fdmul-ai0IwfXt1ps9vV1-Xq8ulZsUfQBuhlQ</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>MOOKERJEE, ISHANEE</creator><creator>TANG, MIMI L.K.</creator><creator>SOLLY, NATASHA</creator><creator>TREGEAR, GEOFFREY W.</creator><creator>SAMUEL, CHRISHAN S.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>200505</creationdate><title>Investigating the Role of Relaxin in the Regulation of Airway Fibrosis in Animal Models of Acute and Chronic Allergic Airway Disease</title><author>MOOKERJEE, ISHANEE ; TANG, MIMI L.K. ; SOLLY, NATASHA ; TREGEAR, GEOFFREY W. ; SAMUEL, CHRISHAN S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4114-37fecef8889be3a86adc95cdd650c996c7da663e8005b593ff4cde26858252c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acute and chronic allergic airway disease</topic><topic>Acute Disease</topic><topic>airway/lung fibrosis</topic><topic>Airways</topic><topic>Animals</topic><topic>Asthma</topic><topic>Commercial aircraft</topic><topic>Commercial planes</topic><topic>Control</topic><topic>Disease Models, Animal</topic><topic>Fibrosis</topic><topic>Hypersensitivity - metabolism</topic><topic>Hypersensitivity - pathology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Ovalbumin - pharmacology</topic><topic>Pulmonary Disease, Chronic Obstructive - chemically induced</topic><topic>Pulmonary Disease, Chronic Obstructive - metabolism</topic><topic>Pulmonary Disease, Chronic Obstructive - pathology</topic><topic>Pulmonary Fibrosis - metabolism</topic><topic>Pulmonary Fibrosis - pathology</topic><topic>relaxin</topic><topic>Relaxin - deficiency</topic><topic>Relaxin - genetics</topic><topic>Relaxin - metabolism</topic><topic>relaxin-1 knockout mice</topic><topic>Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOOKERJEE, ISHANEE</creatorcontrib><creatorcontrib>TANG, MIMI L.K.</creatorcontrib><creatorcontrib>SOLLY, NATASHA</creatorcontrib><creatorcontrib>TREGEAR, GEOFFREY W.</creatorcontrib><creatorcontrib>SAMUEL, CHRISHAN S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOOKERJEE, ISHANEE</au><au>TANG, MIMI L.K.</au><au>SOLLY, NATASHA</au><au>TREGEAR, GEOFFREY W.</au><au>SAMUEL, CHRISHAN S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating the Role of Relaxin in the Regulation of Airway Fibrosis in Animal Models of Acute and Chronic Allergic Airway Disease</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2005-05</date><risdate>2005</risdate><volume>1041</volume><issue>1</issue><spage>194</spage><epage>196</epage><pages>194-196</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Airway remodeling is a characteristic feature of asthma that leads to chronic irreversible airway obstruction. Fibrosis in the basement membrane region is a hallmark of remodeling in asthma that is not found in other diseases. In the outlined studies, we investigated the relationship between relaxin and airway fibrosis in asthma using acute and chronic models of allergic airway disease. These studies confirm a critical role for relaxin, in the regulation of collagen deposition in the airway/lung in animal models of allergic airway disease.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15956707</pmid><doi>10.1196/annals.1282.029</doi><tpages>3</tpages></addata></record> |
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| ispartof | Annals of the New York Academy of Sciences, 2005-05, Vol.1041 (1), p.194-196 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acute and chronic allergic airway disease Acute Disease airway/lung fibrosis Airways Animals Asthma Commercial aircraft Commercial planes Control Disease Models, Animal Fibrosis Hypersensitivity - metabolism Hypersensitivity - pathology Mice Mice, Knockout Ovalbumin - pharmacology Pulmonary Disease, Chronic Obstructive - chemically induced Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology relaxin Relaxin - deficiency Relaxin - genetics Relaxin - metabolism relaxin-1 knockout mice Remodeling |
| title | Investigating the Role of Relaxin in the Regulation of Airway Fibrosis in Animal Models of Acute and Chronic Allergic Airway Disease |
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