Cationic Bovine Serum Albumin Based Self-Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer

It is generally believed that intravenous application of cationic vectors is limited by the binding of abundant negatively charged serum components, which may cause rapid clearance of the therapeutic agent from the blood stream. However, previous studies show that systemic delivery of cationic gene...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2014-02, Vol.10 (3), p.524-535
Hauptverfasser:	Han, Jianfeng, Wang, Qin, Zhang, Zhirong, Gong, Tao, Sun, Xun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cationic cationic bovine serum albumin Cations Cattle Cell Death Cell Line, Tumor Delivery systems drug delivery Flow Cytometry Gene Silencing Gene Transfer Techniques Humans Lung Neoplasms - pathology Lung Neoplasms - secondary Lung Neoplasms - therapy Lungs Mathematical analysis Medical research Medical treatment metastatic cancer therapy Mice Mice, Inbred C57BL Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Nanotechnology Particle Size Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Small Interfering - metabolism Serum albumin Serum Albumin, Bovine - metabolism siRNA Vectors (mathematics)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!