Liquid chromatography–tandem mass spectrometry determination of baclofen in various biological samples and application to a pharmacokinetic study

•A simple and rapid LC–MS/MS assay was developed for determination of baclofen concentration in the biological samples.•Using one-step protein precipitation, minimal matrix effect as well as high sensitivity was achieved.•The assay was fully validated in the various biological samples, i.e. rat plas...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2013-11, Vol.938, p.43-50
Hauptverfasser:	Kim, Tae Hwan, Shin, Soyoung, Shin, Jeong Cheol, Choi, Jin Ho, Seo, Won Sik, Park, Gi-Young, Kwon, Dong Rak, Yoo, Sun Dong, Lee, Ah-Ram, Joo, Sang Hoon, Min, Byung Sun, Yoo, Won Young, Shin, Beom Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Assaying Baclofen Baclofen - analysis Baclofen - chemistry Baclofen - pharmacokinetics Biological Brain Chromatography Chromatography, High Pressure Liquid - methods Drug Stability Kidneys LC/MS/MS Least-Squares Analysis Limit of Detection Linearity Liver Male Pharmacokinetics Rats Rats, Sprague-Dawley Reproducibility of Results Tandem Mass Spectrometry - methods Tissue Distribution Urine
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