Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation-Induced Emission

Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation-Induced Emission

Tetraphenylethene and doxorubicin are assembled into a self‐indicating drug delivery system (TD NPs). TD NPs are decomposed into DOX and TPE NPs in lysosome. Since TD NPs, TPE NPs and DOX are all fluorescent, the detachment of DOX from TPE NPs is accompanied by fluorescence changing. By observing th...

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Veröffentlicht in:Advanced materials (Weinheim) 2014-02, Vol.26 (5), p.712-717
Hauptverfasser: Xue, Xiangdong, Zhao, Yuanyuan, Dai, Luru, Zhang, Xu, Hao, Xiaohong, Zhang, Chunqiu, Huo, Shuaidong, Liu, Juan, Liu, Chang, Kumar, Anil, Chen, Wei-Qiang, Zou, Guozhang, Liang, Xing-Jie
Format: Artikel
Sprache:eng
Schlagworte:
aggregation-induced emission
Cell Survival - drug effects
Decomposition
Doxorubicin
Doxorubicin - chemistry
Doxorubicin - toxicity
Drug Carriers - chemistry
drug delivery system
Drug delivery systems
Drugs
Emission
Fluorescence
Humans
Hydrogen-Ion Concentration
Lysosomes
MCF-7 Cells
nanoaggregation
Nanoparticles - chemistry
self-indicating nanoparticles
spatiotemporal drug release
Thermoplastic elastomers
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Zusammenfassung:Tetraphenylethene and doxorubicin are assembled into a self‐indicating drug delivery system (TD NPs). TD NPs are decomposed into DOX and TPE NPs in lysosome. Since TD NPs, TPE NPs and DOX are all fluorescent, the detachment of DOX from TPE NPs is accompanied by fluorescence changing. By observing the fluorescence changes, the spatiotemporal drug release is visualized.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201302365