Chronic Ethanol Administration Alters Hepatic Surface Membranes as Evidenced by Decreased Concanavalin A Binding

Abstract The effects of chronic ethanol administration on the hepatic surface membrane were examined. The binding of the lectin, concanavalin A (Con A), to isolated hepatocytes was used to ascertain changes in the hepatic plasma membrane, especially in regard to glycoprotein composition, due to chro...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1987-05, Vol.185 (1), p.1-5
Hauptverfasser:	Metcalf, Jordan P., Casey, Carol A., Sorrell, Michael F., Tuma, Dean J.
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology AGGLUTININS Alcoholism - immunology Alcoholism - pathology Alcoholism and acute alcohol poisoning ALCOHOLS ANIMAL CELLS ANIMALS ANTIBODIES BIOCHEMICAL REACTION KINETICS Biological and medical sciences BODY CARBOHYDRATES CELL CONSTITUENTS Cell Membrane - immunology Cell Membrane - ultrastructure CELL MEMBRANES CHRONIC INTAKE CONCANAVALIN DIGESTIVE SYSTEM DISEASES ETHANOL Ethanol - pharmacology GLANDS GLUCOPROTEINS HEMAGGLUTININS HYDROXY COMPOUNDS INTAKE KINETICS LECTINS LIVER Liver - drug effects Liver - pathology LIVER CELLS Male MAMMALS Medical sciences MEMBRANES METABOLIC DISEASES ORGANIC COMPOUNDS ORGANS PATHOGENESIS PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred Strains REACTION KINETICS Receptors, Concanavalin A - metabolism RODENTS SACCHARIDES SOMATIC CELLS TOXICITY Toxicology VERTEBRATES
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