Topical Anti‐inflammatory Potential of Standardized Pomegranate Rind Extract and Ellagic Acid in Contact Dermatitis
The present study evaluated the topical anti‐inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol‐induced mouse ear edema, topical application of SPRE (5, 2...
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| Veröffentlicht in: | Phytotherapy research 2014-04, Vol.28 (4), p.629-632 |
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| creator | Mo, Jiao Panichayupakaranant, Pharkphoom Kaewnopparat, Nattha Songkro, Sarunyoo Reanmongkol, Wantana |
| description | The present study evaluated the topical anti‐inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol‐induced mouse ear edema, topical application of SPRE (5, 2.5, and 1 mg/ear) and EA (0.65, 0.325, and 0.13 mg/ear, equivalent to its content in SPRE) dose‐dependently reduced the ear edema with the maximal inhibition of 79.12% and 73.63%, respectively. Triamcinolone (0.1 mg/ear) and diclofenac (1 mg/ear) as reference drugs inhibited the edema by 73.63% and 37.91%. Myeloperoxidase (MPO) activity in the mouse ear was also decreased by SPRE and EA up to 69.68% and 68.79%, respectively. Triamcinolone and diclofenac decreased the MPO activity by 76.66% and 80.14% similarly. The results indicated that topical application of SPRE and EA is promising for use in the treatment of inflammatory skin disorders. Copyright © 2013 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.5039 |
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In the phenol‐induced mouse ear edema, topical application of SPRE (5, 2.5, and 1 mg/ear) and EA (0.65, 0.325, and 0.13 mg/ear, equivalent to its content in SPRE) dose‐dependently reduced the ear edema with the maximal inhibition of 79.12% and 73.63%, respectively. Triamcinolone (0.1 mg/ear) and diclofenac (1 mg/ear) as reference drugs inhibited the edema by 73.63% and 37.91%. Myeloperoxidase (MPO) activity in the mouse ear was also decreased by SPRE and EA up to 69.68% and 68.79%, respectively. Triamcinolone and diclofenac decreased the MPO activity by 76.66% and 80.14% similarly. The results indicated that topical application of SPRE and EA is promising for use in the treatment of inflammatory skin disorders. Copyright © 2013 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5039</identifier><identifier>PMID: 23873506</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>animal models ; Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents - pharmacology ; contact dermatitis ; Dermatitis, Contact - drug therapy ; Disease Models, Animal ; ears ; edema ; Edema - chemically induced ; Edema - drug therapy ; ellagic acid ; Ellagic Acid - pharmacology ; Fruit - chemistry ; inflammation ; Male ; Mice ; Mice, Inbred ICR ; myeloperoxidase ; Peroxidase - metabolism ; Phenols - adverse effects ; Plant Extracts - pharmacology ; pomegranates ; Punica granatum ; Punicaceae - chemistry ; topical application ; triamcinolone</subject><ispartof>Phytotherapy research, 2014-04, Vol.28 (4), p.629-632</ispartof><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4119-4ee49e982d9ef997952a0329665d1db3f84cf0a4f7efe7f2a43221bc83b877c93</citedby><cites>FETCH-LOGICAL-c4119-4ee49e982d9ef997952a0329665d1db3f84cf0a4f7efe7f2a43221bc83b877c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.5039$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.5039$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23873506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mo, Jiao</creatorcontrib><creatorcontrib>Panichayupakaranant, Pharkphoom</creatorcontrib><creatorcontrib>Kaewnopparat, Nattha</creatorcontrib><creatorcontrib>Songkro, Sarunyoo</creatorcontrib><creatorcontrib>Reanmongkol, Wantana</creatorcontrib><title>Topical Anti‐inflammatory Potential of Standardized Pomegranate Rind Extract and Ellagic Acid in Contact Dermatitis</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The present study evaluated the topical anti‐inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol‐induced mouse ear edema, topical application of SPRE (5, 2.5, and 1 mg/ear) and EA (0.65, 0.325, and 0.13 mg/ear, equivalent to its content in SPRE) dose‐dependently reduced the ear edema with the maximal inhibition of 79.12% and 73.63%, respectively. Triamcinolone (0.1 mg/ear) and diclofenac (1 mg/ear) as reference drugs inhibited the edema by 73.63% and 37.91%. Myeloperoxidase (MPO) activity in the mouse ear was also decreased by SPRE and EA up to 69.68% and 68.79%, respectively. Triamcinolone and diclofenac decreased the MPO activity by 76.66% and 80.14% similarly. The results indicated that topical application of SPRE and EA is promising for use in the treatment of inflammatory skin disorders. Copyright © 2013 John Wiley & Sons, Ltd.</description><subject>animal models</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>contact dermatitis</subject><subject>Dermatitis, Contact - drug therapy</subject><subject>Disease Models, Animal</subject><subject>ears</subject><subject>edema</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>ellagic acid</subject><subject>Ellagic Acid - pharmacology</subject><subject>Fruit - chemistry</subject><subject>inflammation</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>myeloperoxidase</subject><subject>Peroxidase - metabolism</subject><subject>Phenols - adverse effects</subject><subject>Plant Extracts - pharmacology</subject><subject>pomegranates</subject><subject>Punica granatum</subject><subject>Punicaceae - chemistry</subject><subject>topical application</subject><subject>triamcinolone</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks1uEzEURi0EoqEg8QQwEhs2U_wbj5dRWgpSFao2BXaW47mOXGbGwXZEw4pH4Bl5EjxKKBISK1v-jo6u7meEnhN8QjCmbzY5ngjM1AM0IVipmgjJHqIJVoLUnDSfj9CTlG4xxopi_hgdUdZIJvB0grbLsPHWdNVsyP7Xj59-cJ3pe5ND3FWXIUN5Lmlw1XU2Q2ti679DW5Ie1tEMJkN15Ye2OrvL0dhcmfHedWbtbTWzvq38UM3DkMfsFGIR--zTU_TImS7Bs8N5jG7eni3n7-qLD-fv57OL2nJCVM0BuALV0FaBU0oqQQ1mVE2noiXtirmGW4cNdxIcSEcNZ5SSlW3YqpHSKnaMXu-9mxi-biFl3ftkocw3QNgmTQRhWEjZ0IK--ge9Dds4lOlGigpKeSP-Cm0MKUVwehN9b-JOE6zHKnSpQo9VFPTFQbhd9dDeg392X4B6D3zzHez-K9KXy6uD8MD7lOHunjfxi55KJoX-tDjX4iNu2GIx16eFf7nnnQnarKNP-uaaYsLLP5BKSsJ-A5tqq8o</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Mo, Jiao</creator><creator>Panichayupakaranant, Pharkphoom</creator><creator>Kaewnopparat, Nattha</creator><creator>Songkro, Sarunyoo</creator><creator>Reanmongkol, Wantana</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Topical Anti‐inflammatory Potential of Standardized Pomegranate Rind Extract and Ellagic Acid in Contact Dermatitis</title><author>Mo, Jiao ; Panichayupakaranant, Pharkphoom ; Kaewnopparat, Nattha ; Songkro, Sarunyoo ; Reanmongkol, Wantana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4119-4ee49e982d9ef997952a0329665d1db3f84cf0a4f7efe7f2a43221bc83b877c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>animal models</topic><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>contact dermatitis</topic><topic>Dermatitis, Contact - drug therapy</topic><topic>Disease Models, Animal</topic><topic>ears</topic><topic>edema</topic><topic>Edema - chemically induced</topic><topic>Edema - drug therapy</topic><topic>ellagic acid</topic><topic>Ellagic Acid - pharmacology</topic><topic>Fruit - chemistry</topic><topic>inflammation</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>myeloperoxidase</topic><topic>Peroxidase - metabolism</topic><topic>Phenols - adverse effects</topic><topic>Plant Extracts - pharmacology</topic><topic>pomegranates</topic><topic>Punica granatum</topic><topic>Punicaceae - chemistry</topic><topic>topical application</topic><topic>triamcinolone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mo, Jiao</creatorcontrib><creatorcontrib>Panichayupakaranant, Pharkphoom</creatorcontrib><creatorcontrib>Kaewnopparat, Nattha</creatorcontrib><creatorcontrib>Songkro, Sarunyoo</creatorcontrib><creatorcontrib>Reanmongkol, Wantana</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mo, Jiao</au><au>Panichayupakaranant, Pharkphoom</au><au>Kaewnopparat, Nattha</au><au>Songkro, Sarunyoo</au><au>Reanmongkol, Wantana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical Anti‐inflammatory Potential of Standardized Pomegranate Rind Extract and Ellagic Acid in Contact Dermatitis</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2014-04</date><risdate>2014</risdate><volume>28</volume><issue>4</issue><spage>629</spage><epage>632</epage><pages>629-632</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>The present study evaluated the topical anti‐inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol‐induced mouse ear edema, topical application of SPRE (5, 2.5, and 1 mg/ear) and EA (0.65, 0.325, and 0.13 mg/ear, equivalent to its content in SPRE) dose‐dependently reduced the ear edema with the maximal inhibition of 79.12% and 73.63%, respectively. Triamcinolone (0.1 mg/ear) and diclofenac (1 mg/ear) as reference drugs inhibited the edema by 73.63% and 37.91%. Myeloperoxidase (MPO) activity in the mouse ear was also decreased by SPRE and EA up to 69.68% and 68.79%, respectively. Triamcinolone and diclofenac decreased the MPO activity by 76.66% and 80.14% similarly. The results indicated that topical application of SPRE and EA is promising for use in the treatment of inflammatory skin disorders. Copyright © 2013 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23873506</pmid><doi>10.1002/ptr.5039</doi><tpages>4</tpages></addata></record> |
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| subjects | animal models Animals anti-inflammatory activity Anti-Inflammatory Agents - pharmacology contact dermatitis Dermatitis, Contact - drug therapy Disease Models, Animal ears edema Edema - chemically induced Edema - drug therapy ellagic acid Ellagic Acid - pharmacology Fruit - chemistry inflammation Male Mice Mice, Inbred ICR myeloperoxidase Peroxidase - metabolism Phenols - adverse effects Plant Extracts - pharmacology pomegranates Punica granatum Punicaceae - chemistry topical application triamcinolone |
| title | Topical Anti‐inflammatory Potential of Standardized Pomegranate Rind Extract and Ellagic Acid in Contact Dermatitis |
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