The effect of incisura angularis biopsy sampling on the assessment of gastritis stage
OBJECTIVESIt is important to stratify patients according to the magnitude of risk for gastric cancer development; the OLGA (Operative Link for Gastritis Assessment) and OLGIM (Operative Link on Gastric Intestinal Metaplasia) staging systems of lesions in the stomach mucosa have been proposed for thi...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2014-05, Vol.26 (5), p.510-513 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Isajevs, Sergejs Liepniece-Karele, Inta Janciauskas, Dainius Moisejevs, Georgijs Funka, Konrads Kikuste, Ilze Vanags, Aigars Tolmanis, Ivars Leja, Marcis |
| description | OBJECTIVESIt is important to stratify patients according to the magnitude of risk for gastric cancer development; the OLGA (Operative Link for Gastritis Assessment) and OLGIM (Operative Link on Gastric Intestinal Metaplasia) staging systems of lesions in the stomach mucosa have been proposed for this purpose. There are some discrepancies in the current guidelines regarding the value of incisura angularis biopsies. The aim of our study was to assess the value of incisura angularis biopsy in staging gastritis according to the OLGA and OLGIM systems by examining the atrophic, metaplastic and inflammatory changes in the antrum, incisura angularis and corpus.
PATIENTS AND METHODSWe enrolled 835 patients undergoing upper endoscopy. Three expert gastrointestinal pathologists graded biopsy specimens according to the Sydney classification and the stage of gastritis was assessed by the OLGA and OLGIM systems.
RESULTSThe results demonstrated that severe atrophic, metaplastic and chronic inflammatory changes were more frequently observed in the incisura angularis mucosa than in the antrum or corpus mucosae (P |
| doi_str_mv | 10.1097/MEG.0000000000000082 |
| format | Article |
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PATIENTS AND METHODSWe enrolled 835 patients undergoing upper endoscopy. Three expert gastrointestinal pathologists graded biopsy specimens according to the Sydney classification and the stage of gastritis was assessed by the OLGA and OLGIM systems.
RESULTSThe results demonstrated that severe atrophic, metaplastic and chronic inflammatory changes were more frequently observed in the incisura angularis mucosa than in the antrum or corpus mucosae (P<0.05). There was a general downgrading of stage by 18.0% for OLGA and by 4.0% for OLGIM when the incisura angularis was excluded from the staging. Furthermore, there was a 30–35% downgrading for high-risk OLGA/OLGIM stages.
CONCLUSIONThe incisura angularis undergoes more severe atrophic, metaplastic and chronic inflammatory changes than the antrum and corpus. Incisura angularis biopsies should be routinely included in the biopsy sampling protocol.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/MEG.0000000000000082</identifier><identifier>PMID: 24625520</identifier><language>eng</language><publisher>England: Wolters Kluwer Health | Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Atrophy ; Biopsy - methods ; Gastric Mucosa - pathology ; Gastritis - complications ; Gastritis - pathology ; Gastroscopy ; Humans ; Metaplasia ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Pyloric Antrum - pathology ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Stomach - pathology ; Stomach Neoplasms - etiology ; Stomach Neoplasms - pathology ; Young Adult</subject><ispartof>European journal of gastroenterology & hepatology, 2014-05, Vol.26 (5), p.510-513</ispartof><rights>2014 Wolters Kluwer Health | Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3562-14b6b4d00661cb5bd893d8fbadca26bf16c3f01c63a4b2c0eb35b303c09f0aec3</citedby><cites>FETCH-LOGICAL-c3562-14b6b4d00661cb5bd893d8fbadca26bf16c3f01c63a4b2c0eb35b303c09f0aec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24625520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Isajevs, Sergejs</creatorcontrib><creatorcontrib>Liepniece-Karele, Inta</creatorcontrib><creatorcontrib>Janciauskas, Dainius</creatorcontrib><creatorcontrib>Moisejevs, Georgijs</creatorcontrib><creatorcontrib>Funka, Konrads</creatorcontrib><creatorcontrib>Kikuste, Ilze</creatorcontrib><creatorcontrib>Vanags, Aigars</creatorcontrib><creatorcontrib>Tolmanis, Ivars</creatorcontrib><creatorcontrib>Leja, Marcis</creatorcontrib><title>The effect of incisura angularis biopsy sampling on the assessment of gastritis stage</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>OBJECTIVESIt is important to stratify patients according to the magnitude of risk for gastric cancer development; the OLGA (Operative Link for Gastritis Assessment) and OLGIM (Operative Link on Gastric Intestinal Metaplasia) staging systems of lesions in the stomach mucosa have been proposed for this purpose. There are some discrepancies in the current guidelines regarding the value of incisura angularis biopsies. The aim of our study was to assess the value of incisura angularis biopsy in staging gastritis according to the OLGA and OLGIM systems by examining the atrophic, metaplastic and inflammatory changes in the antrum, incisura angularis and corpus.
PATIENTS AND METHODSWe enrolled 835 patients undergoing upper endoscopy. Three expert gastrointestinal pathologists graded biopsy specimens according to the Sydney classification and the stage of gastritis was assessed by the OLGA and OLGIM systems.
RESULTSThe results demonstrated that severe atrophic, metaplastic and chronic inflammatory changes were more frequently observed in the incisura angularis mucosa than in the antrum or corpus mucosae (P<0.05). There was a general downgrading of stage by 18.0% for OLGA and by 4.0% for OLGIM when the incisura angularis was excluded from the staging. Furthermore, there was a 30–35% downgrading for high-risk OLGA/OLGIM stages.
CONCLUSIONThe incisura angularis undergoes more severe atrophic, metaplastic and chronic inflammatory changes than the antrum and corpus. Incisura angularis biopsies should be routinely included in the biopsy sampling protocol.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrophy</subject><subject>Biopsy - methods</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastritis - complications</subject><subject>Gastritis - pathology</subject><subject>Gastroscopy</subject><subject>Humans</subject><subject>Metaplasia</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Pyloric Antrum - pathology</subject><subject>Reproducibility of Results</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - etiology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Young Adult</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQQC0EoqXwDxDKyJJix7GTjKiCglTE0kpske2cU0M-ii9R1X9PoAUJBm655b076RFyyeiU0Sy5ebqbT-mvSaMjMmZxwkMh0-SYjGkm4lBm7GVEzhBfKWUJZ8kpGUWxjISI6JislmsIwFowXdDawDXGYe9VoJqyr5R3GGjXbnAXoKo3lWvKoG2CbnAUIiDW0Hx5pcLOu27AsVMlnJMTqyqEi8OekNX93XL2EC6e54-z20VouJBRyGItdVxQKiUzWugizXiRWq0KoyKpLZOGW8qM5CrWkaGgudCcckMzSxUYPiHX-7sb3773gF1eOzRQVaqBtsecCcZpLDLBBzTeo8a3iB5svvGuVn6XM5p_Bs2HoPnfoIN2dfjQ6xqKH-m74ACke2DbVh14fKv6Lfh8Darq1v_f_gAXX4Lu</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Isajevs, Sergejs</creator><creator>Liepniece-Karele, Inta</creator><creator>Janciauskas, Dainius</creator><creator>Moisejevs, Georgijs</creator><creator>Funka, Konrads</creator><creator>Kikuste, Ilze</creator><creator>Vanags, Aigars</creator><creator>Tolmanis, Ivars</creator><creator>Leja, Marcis</creator><general>Wolters Kluwer Health | Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>The effect of incisura angularis biopsy sampling on the assessment of gastritis stage</title><author>Isajevs, Sergejs ; Liepniece-Karele, Inta ; Janciauskas, Dainius ; Moisejevs, Georgijs ; Funka, Konrads ; Kikuste, Ilze ; Vanags, Aigars ; Tolmanis, Ivars ; Leja, Marcis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3562-14b6b4d00661cb5bd893d8fbadca26bf16c3f01c63a4b2c0eb35b303c09f0aec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrophy</topic><topic>Biopsy - methods</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastritis - complications</topic><topic>Gastritis - pathology</topic><topic>Gastroscopy</topic><topic>Humans</topic><topic>Metaplasia</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Pyloric Antrum - pathology</topic><topic>Reproducibility of Results</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - etiology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Isajevs, Sergejs</creatorcontrib><creatorcontrib>Liepniece-Karele, Inta</creatorcontrib><creatorcontrib>Janciauskas, Dainius</creatorcontrib><creatorcontrib>Moisejevs, Georgijs</creatorcontrib><creatorcontrib>Funka, Konrads</creatorcontrib><creatorcontrib>Kikuste, Ilze</creatorcontrib><creatorcontrib>Vanags, Aigars</creatorcontrib><creatorcontrib>Tolmanis, Ivars</creatorcontrib><creatorcontrib>Leja, Marcis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Isajevs, Sergejs</au><au>Liepniece-Karele, Inta</au><au>Janciauskas, Dainius</au><au>Moisejevs, Georgijs</au><au>Funka, Konrads</au><au>Kikuste, Ilze</au><au>Vanags, Aigars</au><au>Tolmanis, Ivars</au><au>Leja, Marcis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of incisura angularis biopsy sampling on the assessment of gastritis stage</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2014-05</date><risdate>2014</risdate><volume>26</volume><issue>5</issue><spage>510</spage><epage>513</epage><pages>510-513</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>OBJECTIVESIt is important to stratify patients according to the magnitude of risk for gastric cancer development; the OLGA (Operative Link for Gastritis Assessment) and OLGIM (Operative Link on Gastric Intestinal Metaplasia) staging systems of lesions in the stomach mucosa have been proposed for this purpose. There are some discrepancies in the current guidelines regarding the value of incisura angularis biopsies. The aim of our study was to assess the value of incisura angularis biopsy in staging gastritis according to the OLGA and OLGIM systems by examining the atrophic, metaplastic and inflammatory changes in the antrum, incisura angularis and corpus.
PATIENTS AND METHODSWe enrolled 835 patients undergoing upper endoscopy. Three expert gastrointestinal pathologists graded biopsy specimens according to the Sydney classification and the stage of gastritis was assessed by the OLGA and OLGIM systems.
RESULTSThe results demonstrated that severe atrophic, metaplastic and chronic inflammatory changes were more frequently observed in the incisura angularis mucosa than in the antrum or corpus mucosae (P<0.05). There was a general downgrading of stage by 18.0% for OLGA and by 4.0% for OLGIM when the incisura angularis was excluded from the staging. Furthermore, there was a 30–35% downgrading for high-risk OLGA/OLGIM stages.
CONCLUSIONThe incisura angularis undergoes more severe atrophic, metaplastic and chronic inflammatory changes than the antrum and corpus. Incisura angularis biopsies should be routinely included in the biopsy sampling protocol.</abstract><cop>England</cop><pub>Wolters Kluwer Health | Lippincott Williams & Wilkins</pub><pmid>24625520</pmid><doi>10.1097/MEG.0000000000000082</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Atrophy Biopsy - methods Gastric Mucosa - pathology Gastritis - complications Gastritis - pathology Gastroscopy Humans Metaplasia Middle Aged Predictive Value of Tests Prognosis Prospective Studies Pyloric Antrum - pathology Reproducibility of Results Risk Assessment Risk Factors Severity of Illness Index Stomach - pathology Stomach Neoplasms - etiology Stomach Neoplasms - pathology Young Adult |
| title | The effect of incisura angularis biopsy sampling on the assessment of gastritis stage |
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